| Bcl2 like protine-12 (Bcl2L12) facilitates experimental airway allergic inflammation by inducing autocrine eotaxin in eosinophils. | Bcl2 like protine-12 (Bcl2L12) facilitates experimental airway allergic inflammation by inducing autocrine eotaxin in eosinophils.
Yang G, Liu JQ, Mo LH, Luo XQ, Li J, Liu ZQ, Liu DB, Liu ZG, Yang PC, Shi JB. | 11/22/2021 |
| MiR-24-3p attenuates IL-1beta-induced chondrocyte injury associated with osteoarthritis by targeting BCL2L12. | MiR-24-3p attenuates IL-1β-induced chondrocyte injury associated with osteoarthritis by targeting BCL2L12.
Xu J, Qian X, Ding R., Free PMC Article | 11/6/2021 |
| Interaction between Ras and Bcl2L12 in B cells suppresses IL-10 expression. | Interaction between Ras and Bcl2L12 in B cells suppresses IL-10 expression.
Li J, Yang G, Luo XQ, Mo LH, Qiu SY, Yang LT, Liu DB, An YF, Yang PC. | 09/18/2021 |
| Identification of Two Novel Circular RNAs Deriving from BCL2L12 and Investigation of Their Potential Value as a Molecular Signature in Colorectal Cancer. | Identification of Two Novel Circular RNAs Deriving from BCL2L12 and Investigation of Their Potential Value as a Molecular Signature in Colorectal Cancer.
Karousi P, Artemaki PI, Sotiropoulou CD, Christodoulou S, Scorilas A, Kontos CK., Free PMC Article | 03/6/2021 |
| The previously reported active promoter of BCL2L12 gene differs from the one we described in our study. If this novel BCL2L12 promoter is confirmed to be active in other malignancies, transcripts generated from this region could be considered as new cancer-specific biomarkers. The results of the study contribute to the better understanding of the transcriptional regulation of the BCL2L12 gene. | Complex transcriptional regulation of the BCL2L12 gene: Novel, active promoter in K562 cells.
Nikcevic G, Drazilov SS, Djurasevic TK, Tosic N, Kontos CK, Scorilas A, Pavlovic S. | 07/25/2020 |
| In this study, we explored co-delivery of a TRAIL expressing plasmid (pTRAIL) and complementary small interfering RNAs (siRNAs) (silencing Bcl2-like 12 [BCL2L12] and superoxide dismutase 1 [SOD1]) to improve the response of breast cancer cells against TRAIL therapy | Breathing New Life into TRAIL for Breast Cancer Therapy: Co-Delivery of pTRAIL and Complementary siRNAs Using Lipopolymers.
Thapa B, Kc R, Bahniuk M, Schmitke J, Hitt M, Lavasanifar A, Kutsch O, Seol DW, Uludag H. | 06/6/2020 |
| BCL2L12 protein expression could be used as a favorable prognostic tissue biomarker in patients with primary advanced-stage LSCC. On the contrary, BCL2 and BAX did not correlate with prognosis in patients with primary LSCC. | Positive BCL2L12 expression predicts favorable prognosis in patients with laryngeal squamous cell carcinoma.
Giotakis AI, Lazaris AC, Kataki A, Kontos CK, Giotakis EI. | 12/7/2019 |
| Increased BCL2L12 v.4 mRNA expression was associated with markers of unfavorable prognosis namely, advanced tumor, ER- (p=0.015)/PR-, Ki-67-positivity and high NPI (Nottingham prognostic index) score | BCL2L12: a multiply spliced gene with independent prognostic significance in breast cancer.
Kladi-Skandali A, Sideris DC, Scorilas A. | 11/2/2019 |
| Bcl2L12 is positively correlated with Th2 cytokine levels in the nasal mucosa of chronic rhinosinusitis with accompanying nasal allergy (CRSa) patients. Bcl2L12 contributes to the Th2 polarization, which may be a novel therapeutic target in the treatment of CRSa. | B cell lymphoma-2-like protein-12 association with T-helper 2 inflammation in chronic rhinosinusitis with allergy.
An YF, Wu YJ, Zeng XH, Song LJ, Ma F, Liao WJ, Liu ZQ, Yang G, Zhang XW, Liu ZG, Zhao CQ, Yang PC. | 08/10/2019 |
| Bcl2L12 plays a crucial role in the induction of Th2 polarization and allergic response in the intestine. The Bcl2L12 in CD4(+) T cells may be a potential target for the treatment of food allergy. | Bcl2L12 plays a critical role in the development of intestinal allergy.
Feng BS, Wu YJ, Hong JY, Geng XR, Liu JQ, Liu ZG, Zheng PY, Yang PC. | 08/10/2019 |
| Bcl2L12 is a critical factor in the induction of aberrant Th2 polarization by upregulating Th2 responses and downregulating Th2 cell apoptosis | Bcl2L12 Contributes to Th2-Biased Inflammation in the Intestinal Mucosa by Regulating CD4(+) T Cell Activities.
Li MG, Liu XY, Liu ZQ, Hong JY, Liu JQ, Zhou CJ, Hu TY, Xiao XJ, Ran PX, Zheng PY, Liu ZG, Yang PC. | 07/6/2019 |
| Peripheral CD4+ T cells express high levels of Bcl2L12 in patients with ulcerative colitis. Bcl2L12 mediates PAR2-induced Th2 cell development to promote inflammation in the pathogenesis of ulcerative colitis. | Bcl2L12 mediates effects of protease-activated receptor-2 on the pathogenesis of Th2-dominated responses of patients with ulcerative colitis.
Feng BS, Wu YJ, Zeng XH, Yu D, Liu ZQ, Zhou CJ, Liu ZG, Zheng PY, Yang PC. | 06/29/2019 |
| Activation of PAR2 inhibits the expression of IL-10 in B cells, which can be reversed by treating B cells with Bcl2L12 shRNA-carrying liposomes. | Protease-activated receptor-2 suppresses interleukin (IL)-10 expression in B cells via upregulating Bcl2L12 in patients with allergic rhinitis.
Xue JM, Yang LT, Yang G, Geng XR, Liu ZQ, Wang S, Zhao HL, Liu ZG, Zhao CQ, Yang PC. | 06/23/2018 |
| BCL2L12 is a new prognostic biomarker for favorable outcome in diffuse large B-cell lymphoma patients on rituximab. | BCL2L12 protein overexpression is associated with favorable outcome in diffuse large B-cell lymphoma patients in the rituximab era.
Papageorgiou SG, Kontos CK, Foukas PG, Panopoulou E, Vasilatou D, Rapti SM, Gkontopoulos K, Bazani E, Panayiotides IG, Dimitriadis G, Scorilas A, Pappa V. | 03/24/2018 |
| stress hormone cortisol suppresses p53 in hepatocellular carcinoma via enhancing Bcl2L12 expression | Stress Hormone Cortisol Enhances Bcl2 Like-12 Expression to Inhibit p53 in Hepatocellular Carcinoma Cells.
Wu W, Liu S, Liang Y, Zhou Z, Bian W, Liu X. | 12/9/2017 |
| TNF-alpha suppresses IL-10 in peripheral B cells via up-regulating Bcl2L12 in patients with ulcerative colitis. | Tumor necrosis factor suppresses interleukin 10 in peripheral B cells via upregulating Bcl2-like protein 12 in patients with inflammatory bowel disease.
Guo X, Li MG, Li SS, Liu FH, Liu ZJ, Yang PC. | 03/18/2017 |
| miR-125a-5p inhibits cell proliferation and induces apoptosis in colon cancer cells via targeting BCL2, BCL2L12 and Mcl-1. | miR-125a-5p inhibits cell proliferation and induces apoptosis in colon cancer via targeting BCL2, BCL2L12 and MCL1.
Tong Z, Liu N, Lin L, Guo X, Yang D, Zhang Q. | 11/12/2016 |
| Identify 50 novel BCL2L12 splice variants in human tumor cell lines. | Identification of novel alternative splice variants of the BCL2L12 gene in human cancer cells using next-generation sequencing methodology.
Adamopoulos PG, Kontos CK, Tsiakanikas P, Scorilas A. | 07/16/2016 |
| Results show that high Bcl2L12 mRNA expression was associated with the high-grade breast cancer and triple-negative (TNBC) subtype. Also, the interplay between Bcl2L12 and its variant may be associated with high lymph node metastasis in non-TNBC tumors. | Differential roles of Bcl2L12 and its short variant in breast cancer lymph node metastasis.
Chien ST, Yang TF, Yang MC, Hsu CM, Hong YR, Lee TM. | 04/30/2016 |
| CD82 regulated BCL2L12 expression via STAT5A and AKT signaling and stimulated proliferation and engrafting of leukemia cells. | The novel function of CD82 and its impact on BCL2L12 via AKT/STAT5 signal pathway in acute myelogenous leukemia cells.
Nishioka C, Ikezoe T, Takeuchi A, Nobumoto A, Tsuda M, Yokoyama A. | 04/16/2016 |
| Bcl2L12 retains a BH3-like domain, which is important for its anti-apoptotic property. | Bcl2L12 with a BH3-like domain in regulating apoptosis and TMZ-induced autophagy: a prospective combination of ABT-737 and TMZ for treating glioma.
Yang MC, Loh JK, Li YY, Huang WS, Chou CH, Cheng JT, Wang YT, Lieu AS, Howng SL, Hong YR, Chou AK. | 10/10/2015 |
| Data indicate that BCL2-like 12 (proline rich) protein BCL2L12 mRNA levels can distinguish women with breast cancer from healthy controls. | BCL2L12: a promising molecular prognostic biomarker in breast cancer.
Tzovaras A, Kladi-Skandali A, Michaelidou K, Zografos GC, Missitzis I, Ardavanis A, Scorilas A. | 08/22/2015 |
| Data indicate that BCL2L12 expression levels were associated with poor disease-free survival of the high-grade TaT1 bladder cancer patients. | Increased BCL2L12 expression predicts the short-term relapse of patients with TaT1 bladder cancer following transurethral resection of bladder tumors.
Foutadakis S, Avgeris M, Tokas T, Stravodimos K, Scorilas A. | 09/27/2014 |
| Bcl2L12 was previously shown to inhibit apoptosis through binding to caspase 7. | Estrogen receptor β isoform 5 confers sensitivity of breast cancer cell lines to chemotherapeutic agent-induced apoptosis through interaction with Bcl2L12.
Lee MT, Ho SM, Tarapore P, Chung I, Leung YK., Free PMC Article | 08/30/2014 |
| cisplatin treatment induced a time-dependent apoptosis in glioblastoma cells, at least partially via downregulation of BCL2L12 gene expression. | Cisplatin downregulates BCL2L12, a novel apoptosis-related gene, in glioblastoma cells.
Taghavi MS, Akbarzadeh A, Mahdian R, Azadmanesh K, Javadi G. | 02/15/2014 |