| Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors. | Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors.
Ruiz-Viroga V, de Ceglia M, Morelli L, Castaño EM, Calvo EB, Suárez J, Rodríguez de Fonseca F, Galeano P, Lagos P. | 02/16/2023 |
| Properties of primary cilia in melanin-concentrating hormone receptor 1-bearing hippocampal neurons in vivo and in vitro. | Properties of primary cilia in melanin-concentrating hormone receptor 1-bearing hippocampal neurons in vivo and in vitro.
Kobayashi Y, Okada T, Miki D, Sekino Y, Koganezawa N, Shirao T, Diniz GB, Saito Y. | 10/30/2021 |
| Ciliary melanin-concentrating hormone receptor 1 (MCHR1) is widely distributed in the murine CNS in a sex-independent manner. | Ciliary melanin-concentrating hormone receptor 1 (MCHR1) is widely distributed in the murine CNS in a sex-independent manner.
Diniz GB, Battagello DS, Klein MO, Bono BSM, Ferreira JGP, Motta-Teixeira LC, Duarte JCG, Presse F, Nahon JL, Adamantidis A, Chee MJ, Sita LV, Bittencourt JC. | 09/18/2021 |
| data suggest a dual role of MCH and the MCH1-R in regulation of alcohol intake, possibly through mechanisms involving caloric intake and reward motivation. | Melanin-Concentrating Hormone and Its MCH-1 Receptor: Relationship Between Effects on Alcohol and Caloric Intake.
Karlsson C, Aziz AM, Rehman F, Pitcairn C, Barchiesi R, Barbier E, Wendel Hansen M, Gehlert D, Steensland P, Heilig M, Thorsell A. | 12/23/2017 |
| MCH levels in the CSF, brain preproMCH and MCHR1 gene expression during paradoxical sleep deprivation, sleep rebound and chronic sleep restriction were studied in rats. | MCH levels in the CSF, brain preproMCH and MCHR1 gene expression during paradoxical sleep deprivation, sleep rebound and chronic sleep restriction.
Dias Abdo Agamme AL, Aguilar Calegare BF, Fernandes L, Costa A, Lagos P, Torterolo P, D'Almeida V. | 10/1/2016 |
| The study identified the amino acids that are selectively involved in Gi/o activation by rat melanin-concentrating hormone receptor 1. | Identification of amino acids that are selectively involved in Gi/o activation by rat melanin-concentrating hormone receptor 1.
Hamamoto A, Kobayashi Y, Saito Y. | 12/26/2015 |
| Data indicate that Mch/Mchr1 signal transduction participates in modulation of depression-like behavior through processes in CA1 region of hippocampus. Model of depression involves chronically higher Mch expression and down-regulation of Mchr1. | The melanin-concentrating hormone (MCH) system in an animal model of depression-like behavior.
García-Fuster MJ, Parks GS, Clinton SM, Watson SJ, Akil H, Civelli O., Free PMC Article | 01/26/2013 |
| Diet-induced obesity and related metabolic disorders are possibly correlated with up-regulated expression of MCHR1 and down-regulated expression of OB-Rb in adipose tissue. | [High fat diet induces obesity and alters the expression of MCHR1 and OB-Rb in the adipose tissue].
Li J, Yan J, Chen K, Wang Q, Zhao X, Zhang Y. | 01/12/2013 |
| Data suggest that MCH and its receptor (MCHR1) form an orexigenic system whose expression is affected in conditioned taste aversion. MCHR1 expression is up-regulated in hypothalamus and brain stem (and possibly amygdala) of aversive animals. | Expression levels of genes encoding melanin concentrating hormone (MCH) and MCH receptor change in taste aversion, but MCH injections do not alleviate aversive responses.
Mitra A, Klockars A, Gosnell BA, Le Grevès M, Olszewski PK, Levine AS, Schiöth HB., Free PMC Article | 05/5/2012 |
| data suggest that the major contribution of the DRY motif in MCH1R is to govern receptor conformation and G protein coupling/recognition | Distinct roles of the DRY motif in rat melanin-concentrating hormone receptor 1 in signaling control.
Aizaki Y, Maruyama K, Nakano-Tetsuka M, Saito Y. | 01/21/2010 |
| SNAP79441 inhibitis this receptor and reduces the micturition response in rats. | The role of melanin-concentrating hormone-1 receptors in the voiding reflex in rats.
Hegde LG, Ping XL, Jochnowitz N, Craig DA. | 01/21/2010 |
| RGS8, which is highly expressed in the brain, functions as a negative modulator of MCH1R signaling. | Regulation of melanin-concentrating hormone receptor 1 signaling by RGS8 with the receptor third intracellular loop.
Miyamoto-Matsubara M, Saitoh O, Maruyama K, Aizaki Y, Saito Y. | 01/21/2010 |
| the results support a role of the melanin-concentrating hormone MCH(1) receptor in the regulation of deep slow-wave sleep-REM sleep cycle | Blocking melanin-concentrating hormone MCH1 receptor affects rat sleep-wake architecture.
Ahnaou A, Drinkenburg WH, Bouwknecht JA, Alcazar J, Steckler T, Dautzenberg FM. | 01/21/2010 |
| The basic residues in the membrane-proximal C-terminal tail of the rat melanin-concentrating hormone receptor 1 are required for receptor function. | The basic residues in the membrane-proximal C-terminal tail of the rat melanin-concentrating hormone receptor 1 are required for receptor function.
Tetsuka M, Saito Y, Imai K, Doi H, Maruyama K. | 01/21/2010 |
| Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail | Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail.
Murdoch H, Feng GJ, Bächner D, Ormiston L, White JH, Richter D, Milligan G. | 01/21/2010 |
| In nodose ganglia from rats fasted for 24 h, RT-PCR revealed the expression of both melanin-concentrating hormone and MCHR1, whereas in nodose ganglia from animals fed ad libitum expression was virtually undetectable. | Feeding-dependent depression of melanin-concentrating hormone and melanin-concentrating hormone receptor-1 expression in vagal afferent neurones.
Burdyga G, Varro A, Dimaline R, Thompson DG, Dockray GJ. | 01/21/2010 |
| These data support the notion that MIZIP might interact with elanin-concentrating hormone receptor 1 (MCHR1) in a cell type specific manner in vivo, suggesting a role in the regulation of MCH signalling in distinct regions of the mammalian brain. | Immunohistochemical distribution of MIZIP and its co-expression with the Melanin-concentrating hormone receptor 1 in the adult rodent brain.
Francke F, Richter D, Bächner D. | 01/21/2010 |
| Castration and testosterone treatment on the vasculature in the ventral prostate in adult rats and mice alter expression of this protein. | Altered levels of angiopoietin 1 and tie 2 are associated with androgen-regulated vascular regression and growth in the ventral prostate in adult mice and rats.
Johansson A, Rudolfsson SH, Wikström P, Bergh A. | 01/21/2010 |
| MCH1R undergoes rapid melanin concentating hormone-induced internalization and that a portion of the C-terminal tail plays an important role in the internalization process. | Properties of rat melanin-concentrating hormone receptor 1 internalization.
Saito Y, Tetsuka M, Li Y, Kurose H, Maruyama K. | 01/21/2010 |