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    CDCA3 cell division cycle associated 3 [ Homo sapiens (human) ]

    Gene ID: 83461, updated on 14-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Identification of circ_0038632 as a Promoter of Breast Cancer through miR-520a-3p-Dependent Modulation of CDCA3.

    Identification of circ_0038632 as a Promoter of Breast Cancer through miR-520a-3p-Dependent Modulation of CDCA3.
    Zhang H, Zheng Y, Yu L, Liu M, Zhang Y.

    08/28/2023
    MiRNA-144-5p down-modulates CDCA3 to regulate proliferation and apoptosis of lung adenocarcinoma cells.

    MiRNA-144-5p down-modulates CDCA3 to regulate proliferation and apoptosis of lung adenocarcinoma cells.
    Luo J, Xia L, Zhang L, Zhao K, Li C.

    12/10/2022
    CDCA3 exhibits a role in promoting the progression of ovarian cancer.

    CDCA3 exhibits a role in promoting the progression of ovarian cancer.
    Gong S, Bai B, Sun G, Jin H, Zhang Z.

    11/26/2022
    MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3.

    MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3.
    Liu W, Shen D, Ju L, Zhang R, Du W, Jin W, Xiong K, Wang G, Qian K, Zhang Y, Xiao Y, Wang X.

    10/15/2022
    LncCDCA3L inhibits cell proliferation via a novel RNA structure-based crosstalk with CDCA3 in hepatocellular carcinoma.

    LncCDCA3L inhibits cell proliferation via a novel RNA structure-based crosstalk with CDCA3 in hepatocellular carcinoma.
    Wang Y, Liu Y, Zhang T, Guan G, Mao T, Liu H, Zhang J, Lu F, Chen X.

    06/18/2022
    Prognostic value of CDCA3 in kidney renal papillary cell carcinoma.

    Prognostic value of CDCA3 in kidney renal papillary cell carcinoma.
    Li H, Li M, Yang C, Guo F, Deng S, Li L, Ma T, Yan J, Wu H, Li X., Free PMC Article

    02/19/2022
    Suppression of CDCA3 inhibits prostate cancer progression via NFkappaB/cyclin D1 signaling inactivation and p21 accumulation.

    Suppression of CDCA3 inhibits prostate cancer progression via NF‑κB/cyclin D1 signaling inactivation and p21 accumulation.
    Gu P, Zhang M, Zhu J, He X, Yang D., Free PMC Article

    01/22/2022
    Circ_0001421 facilitates glycolysis and lung cancer development by regulating miR-4677-3p/CDCA3.

    Circ_0001421 facilitates glycolysis and lung cancer development by regulating miR-4677-3p/CDCA3.
    Zhang K, Hu H, Xu J, Qiu L, Chen H, Jiang X, Jiang Y., Free PMC Article

    10/2/2021
    Circular RNA hsa_circ_101555 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-145-5p and regulating CDCA3 expression.

    Circular RNA hsa_circ_101555 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-145-5p and regulating CDCA3 expression.
    Gu X, Zhang J, Ran Y, Pan H, Jia J, Zhao Y, Zhao X, Li W, Song S, Yu X., Free PMC Article

    09/25/2021
    Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy.

    Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy.
    Kildey K, Gandhi NS, Sahin KB, Shah ET, Boittier E, Duijf PHG, Molloy C, Burgess JT, Beard S, Bolderson E, Suraweera A, Richard DJ, O'Byrne KJ, Adams MN., Free PMC Article

    08/21/2021
    CDCA3 Is a Novel Prognostic Biomarker Associated with Immune Infiltration in Hepatocellular Carcinoma.

    CDCA3 Is a Novel Prognostic Biomarker Associated with Immune Infiltration in Hepatocellular Carcinoma.
    Wang Z, Chen S, Wang G, Li S, Qin X., Free PMC Article

    05/29/2021
    Long noncoding RNA SNHG12 promotes tumour progression and sunitinib resistance by upregulating CDCA3 in renal cell carcinoma.

    Long noncoding RNA SNHG12 promotes tumour progression and sunitinib resistance by upregulating CDCA3 in renal cell carcinoma.
    Liu Y, Cheng G, Huang Z, Bao L, Liu J, Wang C, Xiong Z, Zhou L, Xu T, Liu D, Yang H, Chen K, Zhang X., Free PMC Article

    03/27/2021
    DNA hypomethylation promotes invasion and metastasis of gastric cancer cells by regulating the binding of SP1 to the CDCA3 promoter.

    DNA hypomethylation promotes invasion and metastasis of gastric cancer cells by regulating the binding of SP1 to the CDCA3 promoter.
    Yu J, Hua R, Zhang Y, Tao R, Wang Q, Ni Q.

    02/27/2021
    Downregulation of CDCA3 expression inhibits tumor formation in pancreatic cancer.

    Downregulation of CDCA3 expression inhibits tumor formation in pancreatic cancer.
    Zou RC, Guo ZT, Wei D, Shi ZT, Ye ZC, Zhai G, Zhong C, Tang B, Wang L, Ge JY.

    02/2/2021
    miR-145-5p suppresses proliferation, metastasis and EMT of colorectal cancer by targeting CDCA3.

    miR-145-5p suppresses proliferation, metastasis and EMT of colorectal cancer by targeting CDCA3.
    Chen Q, Zhou L, Ye X, Tao M, Wu J.

    01/16/2021
    Study results demonstrated that CDCA3 expression was increased in human gastric cancer (GC) tissues compared with those in adjacent nontumor tissues CDCA3 expression was closely associated with features of GC and patients with unfavorable overall survival times. CDCA3 overexpression resulted in the stimulation of cell growth and colony formation in vitro and xenograft tumors in vivo.

    CDCA3 is a potential prognostic marker that promotes cell proliferation in gastric cancer.
    Zhang Y, Yin W, Cao W, Chen P, Bian L, Ni Q.

    06/29/2019
    Study demonstrated that CDCA3 may target p21 to promote colorectal cancer (CRC) cell proliferation and tumorigenesis, at least partially in an E2F1-mediated manner, and that CDCA3 may serve as a potential prognostic and therapeutic target of CRC.

    CDCA3 mediates p21-dependent proliferation by regulating E2F1 expression in colorectal cancer.
    Qian W, Zhang Z, Peng W, Li J, Gu Q, Ji D, Wang Q, Zhang Y, Ji B, Wang S, Zhang D, Sun Y., Free PMC Article

    02/2/2019
    these results define a tumor-supportive role for CDCA3.

    CDCA3 promotes cell proliferation by activating the NF-κB/cyclin D1 signaling pathway in colorectal cancer.
    Zhang W, Lu Y, Li X, Zhang J, Zheng L, Zhang W, Lin C, Lin W, Li X.

    09/22/2018
    Data indicate a miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry which contributes to leukemogenesis and suggest a therapeutic strategy of restoring miR-375 expression in Acute myeloid leukemia (AML).

    A novel miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry contributes to leukemogenesis in acute myeloid leukemia.
    Bi L, Zhou B, Li H, He L, Wang C, Wang Z, Zhu L, Chen M, Gao S., Free PMC Article

    08/25/2018
    OY-TES-1 downregulation in liver cancer cells promotes cell proliferation by upregulating CCND2 and CDCA3.

    OY-TES-1 may regulate the malignant behavior of liver cancer via NANOG, CD9, CCND2 and CDCA3: a bioinformatic analysis combine with RNAi and oligonucleotide microarray.
    Hu Q, Fu J, Luo B, Huang M, Guo W, Lin Y, Xie X, Xiao S.

    01/16/2016
    High CDCA3 expression is associated with neoplasms.

    Translating bioinformatics in oncology: guilt-by-profiling analysis and identification of KIF18B and CDCA3 as novel driver genes in carcinogenesis.
    Itzel T, Scholz P, Maass T, Krupp M, Marquardt JU, Strand S, Becker D, Staib F, Binder H, Roessler S, Wang XW, Thorgeirsson S, Müller M, Galle PR, Teufel A., Free PMC Article

    06/20/2015
    HoxB3 promote prostate cancer progression by upregulating CDCA3 expression.

    HoxB3 promotes prostate cancer cell progression by transactivating CDCA3.
    Chen J, Zhu S, Jiang N, Shang Z, Quan C, Niu Y.

    04/6/2013
    overexpression of CDCA3 occurs frequently during oral carcinogenesis.

    Overexpression of cell cycle regulator CDCA3 promotes oral cancer progression by enhancing cell proliferation with prevention of G1 phase arrest.
    Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Bukawa H., Free PMC Article

    12/22/2012
    Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

    Identification of type 2 diabetes-associated combination of SNPs using support vector machine.
    Ban HJ, Heo JY, Oh KS, Park KJ., Free PMC Article

    06/30/2010
    a repressor element (cell-cycle-dependent element/cell cycle gene homology region) in the vicinity of the transcription start site, and mutations within this element diminished the cell-cycle-dependent transcriptional regulation of Tome-1

    Cell-cycle-dependent regulation of the human and mouse Tome-1 promoters.
    Yoshida K.

    01/21/2010
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