| Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase. | Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase.
Andreev D, Kachler K, Liu M, Chen Z, Krishnacoumar B, Ringer M, Frey S, Krönke G, Voehringer D, Schett G, Bozec A., Free PMC Article | 03/8/2024 |
| Eosinophil Peroxidase: A Biomarker for Eosinophilic Chronic Rhinosinusitis Agnostic of Polyp Status. | Eosinophil Peroxidase: A Biomarker for Eosinophilic Chronic Rhinosinusitis Agnostic of Polyp Status.
Idler BM, Iijima K, Ochkur SI, Jacobsen EA, Rank MA, Kita H, Lal D., | 01/4/2024 |
| EPX is a useful biomarker for eosinophilic inflammation in chronic rhinosinusitis. | Eosinophil peroxidase, GATA3, and T-bet as tissue biomarkers in chronic rhinosinusitis.
Lal D, Wright BL, Shim KP, Zarka MA, Lee JJ, Chang YH, Ochkur SI, Divekar R, Doyle AD, Jacobsen EA, Kita H, Rank MA. | 06/13/2020 |
| peroxidase enzymes, like MPO and EPO, may play a fundamental role in inhibiting RANKL-induced osteoclast differentiation at inflammatory sites of bone fracture and injury. | Peroxidase enzymes inhibit osteoclast differentiation and bone resorption.
Panagopoulos V, Liapis V, Zinonos I, Hay S, Leach DA, Ingman W, DeNichilo MO, Atkins GJ, Findlay DM, Zannettino ACW, Evdokiou A. | 11/18/2017 |
| Both MPO and EPO are causatively involved in breast cancer progression and identified as potential therapeutic targets whereby specific novel inhibitors may reduce tumor growth and limit the occurrence of metastasis. | Inflammatory peroxidases promote breast cancer progression in mice via regulation of the tumour microenvironment.
Panagopoulos V, Leach DA, Zinonos I, Ponomarev V, Licari G, Liapis V, Ingman WV, Anderson P, DeNichilo MO, Evdokiou A. | 07/22/2017 |
| The main significance of this work is the discovery of EPO as a novel ligand for the HER2 receptor. Following HER2 activation, EPO induces activation of FAK and subsequent activation of beta1-integrin, via inside-out signaling. This complex results in downstream activation of ERK1/2 and a sustained up regulation of both MUC4 and the HER2 receptor | Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling.
Hennigan K, Conroy PJ, Walsh MT, Amin M, O'Kennedy R, Ramasamy P, Gleich GJ, Siddiqui Z, Glynn S, McCabe O, Mooney C, Harvey BJ, Costello RW, McBryan J., Free PMC Article | 06/3/2017 |
| EPO-mediated protein carbamylation is promoted during allergen-induced asthma exacerbation, and can both modulate immune responses and trigger a cascade of many of the inflammatory signals present in asthma. | Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma.
Wang Z, DiDonato JA, Buffa J, Comhair SA, Aronica MA, Dweik RA, Lee NA, Lee JJ, Thomassen MJ, Kavuru M, Erzurum SC, Hazen SL., Free PMC Article | 05/27/2017 |
| there is a strong association in a given patient between both nasal and pharyngeal EPX levels and the eosinophil percentage of induced sputum. | Nasal and pharyngeal eosinophil peroxidase levels in adults with poorly controlled asthma correlate with sputum eosinophilia.
Rank MA, Ochkur SI, Lewis JC, Teaford HG 3rd, Wesselius LJ, Helmers RA, Lee NA, Nair P, Lee JJ., Free PMC Article | 12/17/2016 |
| Myeloperoxidase and eosinophil peroxidase are readily internalized by HUVEC cells where they promote cellular proliferation, migration, invasion, and stimulate angiogenesis both in vitro and in vivo. | Uncovering a new role for peroxidase enzymes as drivers of angiogenesis.
Panagopoulos V, Zinonos I, Leach DA, Hay SJ, Liapis V, Zysk A, Ingman WV, DeNichilo MO, Evdokiou A. | 08/13/2016 |
| A preferential role of EPO signaling via a specific surface receptor that leads to neural plasticity. | Eosinophil peroxidase induces expression of cholinergic genes via cell surface neural interactions.
Akasheh N, Walsh MT, Costello RW. | 01/3/2015 |
| mRNA levels of eosinophil granule proteins, rather than sputum eosinophil%, may reflect airway hyperresponsiveness and airflow limitation. | Expression levels of eosinophil granule protein mRNAs in induced sputum reflect airway hyperresponsiveness and airflow limitation.
Jung JW, Kang HR, Lee HS, Park HW, Cho SH, Min KU, Sohn SW. | 12/6/2014 |
| Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia. | Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia.
Nair P, Ochkur SI, Protheroe C, Radford K, Efthimiadis A, Lee NA, Lee JJ., Free PMC Article | 05/10/2014 |
| report the prevalence of a common SNP in the eosinophil protein x/eosinophil-derived neurotoxin (EPX/EDN, RNase2) and the association with the cellular contents of EPX/EDN and ECP | The production of the eosinophil proteins ECP and EPX/EDN are regulated in a reciprocal manner.
Jönsson UB, Blom K, Stålenheim G, Håkansson LD, Venge P. | 04/26/2014 |
| Polymorphisms of EPX and ECP are associated to inflammatory bowel disease in an age and gender dependent manne. | Eosinophil associated genes in the inflammatory bowel disease 4 region: correlation to inflammatory bowel disease revealed.
Blom K, Rubin J, Halfvarson J, Törkvist L, Rönnblom A, Sangfelt P, Lördal M, Jönsson UB, Sjöqvist U, Håkansson LD, Venge P, Carlson M., Free PMC Article | 11/16/2013 |
| Data indicate that eosinophil peroxidase (EPX)-based ELISA is the only eosinophil-specific assay. | A sensitive high throughput ELISA for human eosinophil peroxidase: a specific assay to quantify eosinophil degranulation from patient-derived sources.
Ochkur SI, Kim JD, Protheroe CA, Colbert D, Condjella RM, Bersoux S, Helmers RA, Moqbel R, Lacy P, Kelly EA, Jarjour NN, Kern R, Peters A, Schleimer RP, Furuta GT, Nair P, Lee JJ, Lee NA., Free PMC Article | 12/8/2012 |
| A mechanism of induction of ASIC-3 expression relevant to AR was suggested by the finding that eosinophil peroxidase (EPO), acting via ERK1/2, induced the expression of ASIC-3 in epithelial cells. | Eosinophil peroxidase induces the expression and function of acid-sensing ion channel-3 in allergic rhinitis: in vitro evidence in cultured epithelial cells.
Khoo SG, Al-Alawi M, Walsh MT, Hannigan K, Glynn S, Thornton M, McQuaid S, Wang Y, Hamilton PW, Verriere V, Gleich GJ, Harvey BJ, Costello RW, McGarvey LP. | 10/20/2012 |
| HER2 was identified as a novel mediator of eosinophil peroxidase signaling. Eosinophil peroxidase, at noncytotoxic levels, can drive cell-cycle progression and proliferation. | Eosinophil peroxidase signals via epidermal growth factor-2 to induce cell proliferation.
Walsh MT, Connell K, Sheahan AM, Gleich GJ, Costello RW. | 12/24/2011 |
| EPO-dependent oxidative damage may play a role in tissue injury in bisulfite-exacerbated eosinophilic inflammatory disorders | Protein Radical Formation Resulting from Eosinophil Peroxidase-catalyzed Oxidation of Sulfite.
Ranguelova K, Chatterjee S, Ehrenshaft M, Ramirez DC, Summers FA, Kadiiska MB, Mason RP., Free PMC Article | 09/20/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesA Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC. New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany.
Parwez Q, Stemmler S, Epplen JT, Hoffjan S, Parwez Q, Stemmler S, Epplen JT, Hoffjan S. | 04/7/2010 |
| Genetic variability in the EPO gene may contribute to the susceptibility to allergic rhinitis (or related phenotypes) in the Czech population. | Association of single nucleotide polymorphisms in the eosinophil peroxidase gene with allergic rhinitis in the Czech population.
Hrdlickova B, Izakovicova-Holla L. | 01/21/2010 |
| No variation in genes eosinophil peroxidase for Atopic dermatitis pathogenesis in this German cohort. | Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany.
Parwez Q, Stemmler S, Epplen JT, Hoffjan S, Parwez Q, Stemmler S, Epplen JT, Hoffjan S., Free PMC Articles: PMC2596079, PMC2596079 | 01/21/2010 |
| post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase | Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase.
Ulrich M, Petre A, Youhnovski N, Prömm F, Schirle M, Schumm M, Pero RS, Doyle A, Checkel J, Kita H, Thiyagarajan N, Acharya KR, Schmid-Grendelmeier P, Simon HU, Schwarz H, Tsutsui M, Shimokawa H, Bellon G, Lee JJ, Przybylski M, Döring G., Free PMC Article | 01/21/2010 |
| The mechanisms by which eosinophil peroxidase oxidizes nitrite are reported. | Mechanism of nitrite oxidation by eosinophil peroxidase: implications for oxidant production and nitration by eosinophils.
van Dalen CJ, Winterbourn CC, Kettle AJ., Free PMC Article | 01/21/2010 |
| induces surface alteration, killing, and lysis of Mycobacterium tuberculosis | Human eosinophil peroxidase induces surface alteration, killing, and lysis of Mycobacterium tuberculosis.
Borelli V, Vita F, Shankar S, Soranzo MR, Banfi E, Scialino G, Brochetta C, Zabucchi G., Free PMC Article | 01/21/2010 |
| Analysis of the role of thiocyanate (SCN-), in modulating the catalytic activity of myeloperoxidase (MPO) and other members of the lactoperoxidase (LPO) and eosinophil peroxidase (EPO) | Thiocyanate modulates the catalytic activity of mammalian peroxidases.
Tahboub YR, Galijasevic S, Diamond MP, Abu-Soud HM. | 01/21/2010 |