| Histone demethylase KDM5D upregulation drives sex differences in colon cancer. | Histone demethylase KDM5D upregulation drives sex differences in colon cancer.
Li J, Lan Z, Liao W, Horner JW, Xu X, Liu J, Yoshihama Y, Jiang S, Shim HS, Slotnik M, LaBella KA, Wu CJ, Dunner K Jr, Hsu WH, Lee R, Khanduri I, Terranova C, Akdemir K, Chakravarti D, Shang X, Spring DJ, Wang YA, DePinho RA., Free PMC Article | 07/27/2023 |
| KDM5D inhibits the transcriptional activation of FKBP4 by suppressing the expression of E2F1 in colorectal cancer in males. | KDM5D inhibits the transcriptional activation of FKBP4 by suppressing the expression of E2F1 in colorectal cancer in males.
Liu M, Gao N. | 01/8/2022 |
| X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis. | X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.
Tricarico R, Nicolas E, Hall MJ, Golemis EA., Free PMC Article | 11/27/2021 |
| Y disruption, autosomal hypomethylation and poor male lung cancer survival. | Y disruption, autosomal hypomethylation and poor male lung cancer survival.
Willis-Owen SAG, Domingo-Sabugo C, Starren E, Liang L, Freidin MB, Arseneault M, Zhang Y, Lu SK, Popat S, Lim E, Nicholson AG, Riazalhosseini Y, Lathrop M, Cookson WOC, Moffatt MF., Free PMC Article | 11/6/2021 |
| Increased Expression of Y-Encoded Demethylases During Differentiation of Human Male Neural Stem Cells. | Increased Expression of Y-Encoded Demethylases During Differentiation of Human Male Neural Stem Cells.
Pottmeier P, Doszyn O, Peuckert C, Jazin E. | 09/4/2021 |
| ETV4 promotes the progression of gastric cancer through regulating KDM5D. | ETV4 promotes the progression of gastric cancer through regulating KDM5D.
Cai LS, Chen QX, Fang SY, Lian MQ, Lian MJ, Cai MZ. | 03/20/2021 |
| Down-Regulation of a Male-Specific H3K4 Demethylase, KDM5D, Impairs Cardiomyocyte Differentiation. | Down-Regulation of a Male-Specific H3K4 Demethylase, KDM5D, Impairs Cardiomyocyte Differentiation.
Meyfour A, Pahlavan S, Ansari H, Baharvand H, Salekdeh GH. | 09/5/2020 |
| KDM5D inhibit epithelial-mesenchymal transition of gastric cancer through demethylation in the promoter of Cul4A in male. | KDM5D inhibit epithelial-mesenchymal transition of gastric cancer through demethylation in the promoter of Cul4A in male.
Shen X, Hu K, Cheng G, Xu L, Chen Z, Du P, Zhuang Z. | 08/13/2020 |
| loss of the male-specific histone demethylase lysine-specific demethylase 5D (KDM5D) encoded on the Y chromosome epigenetically modifies histone methylation marks and alters gene expression, resulting in aggressive prostate cancer | ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D.
Komura K, Yoshikawa Y, Shimamura T, Chakraborty G, Gerke TA, Hinohara K, Chadalavada K, Jeong SH, Armenia J, Du SY, Mazzu YZ, Taniguchi K, Ibuki N, Meyer CA, Nanjangud GJ, Inamoto T, Lee GM, Mucci LA, Azuma H, Sweeney CJ, Kantoff PW., Free PMC Article | 09/21/2019 |
| KDM5D exhibited pronounced overexpression in blood vessels with cardiovascular disease. | Proteomics based identification of KDM5 histone demethylases associated with cardiovascular disease.
Mokou M, Klein J, Makridakis M, Bitsika V, Bascands JL, Saulnier-Blache JS, Mullen W, Sacherer M, Zoidakis J, Pieske B, Mischak H, Roubelakis MG, Schanstra JP, Vlahou A., Free PMC Article | 07/27/2019 |
| Loss of KDM5D expression leads to docetaxel resistance in prostate cancer. | Resistance to docetaxel in prostate cancer is associated with androgen receptor activation and loss of KDM5D expression.
Komura K, Jeong SH, Hinohara K, Qu F, Wang X, Hiraki M, Azuma H, Lee GS, Kantoff PW, Sweeney CJ., Free PMC Article | 12/24/2016 |
| The expression profiles of KDM5D isoforms were investigated in prostate cancer cell lines along with their gene regulatory network. | Investigation of Histone Lysine-Specific Demethylase 5D KDM5D) Isoform Expression in Prostate Cancer Cell Lines: a System Approach.
Jangravi Z, Najafi M, Shabani M., Free PMC Article | 10/22/2016 |
| study identifies JARID1D as an anti-invasiveness histone methylation modifier that acts against prostate cancer cell metastasis by repressing metastatic gene programs; results also highlight a preclinical rationale for using JARID1D as a prognostic marker in advanced prostate cancer | JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis.
Li N, Dhar SS, Chen TY, Kan PY, Wei Y, Kim JH, Chan CH, Lin HK, Hung MC, Lee MG., Free PMC Article | 10/8/2016 |
| Of 820 proteins present in all four replicates of two treatments, the abundance of 209 proteins changed significantly in response to KDM5D suppression | Two Splice Variants of Y Chromosome-Located Lysine-Specific Demethylase 5D Have Distinct Function in Prostate Cancer Cell Line (DU-145).
Jangravi Z, Tabar MS, Mirzaei M, Parsamatin P, Vakilian H, Alikhani M, Shabani M, Haynes PA, Goodchild AK, Gourabi H, Baharvand H, Salekdeh GH. | 06/11/2016 |
| compared with other recipient-donor gender combinations, female recipients of male donor kidney transplants in the United States have an increased short-term risk but not long-term risk for adverse outcomes | H-Y incompatibility predicts short-term outcomes for kidney transplant recipients.
Kim SJ, Gill JS., Free PMC Article | 01/21/2010 |
| HY-restricting HLA class II alleles is associated with pregnancy outcome in patients with recurrent miscarriage subsequent to firstborn boys. | Association of HY-restricting HLA class II alleles with pregnancy outcome in patients with recurrent miscarriage subsequent to a firstborn boy.
Nielsen HS, Steffensen R, Varming K, Van Halteren AG, Spierings E, Ryder LP, Goulmy E, Christiansen OB. | 01/21/2010 |
| Results suggest that SMCY may have a male-specific function as a histone H3K4 demethylase by recruiting a meiosis-regulatory protein to condensed DNA. | Spermatogenesis-specific association of SMCY and MSH5.
Akimoto C, Kitagawa H, Matsumoto T, Kato S. | 01/21/2010 |
| The presence of H-Y antibodies correlated with chronic graft-versus-host disease | Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission.
Miklos DB, Kim HT, Miller KH, Guo L, Zorn E, Lee SJ, Hochberg EP, Wu CJ, Alyea EP, Cutler C, Ho V, Soiffer RJ, Antin JH, Ritz J., Free PMC Article | 01/21/2010 |
| HY-specific CD8+ T cells also could be detected directly in the peripheral blood of women with a history of at least two pregnancies that produced males. | Functional HY-specific CD8+ T cells are found in a high proportion of women following pregnancy with a male fetus.
Piper KP, McLarnon A, Arrazi J, Horlock C, Ainsworth J, Kilby MD, Martin WL, Moss PA. | 01/21/2010 |
| Study shows that JARID1d and MBLR occupy human Engrailed 2 gene and regulate its expression and histone H3 lysine 4 methylation levels. | Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein.
Lee MG, Norman J, Shilatifard A, Shiekhattar R. | 01/21/2010 |