| Apo10 and TKTL1 in blood macrophages as biomarkers for differentiating lung cancer from benign lung lesions: a comparative study with conventional biomarkers. | Apo10 and TKTL1 in blood macrophages as biomarkers for differentiating lung cancer from benign lung lesions: a comparative study with conventional biomarkers.
Xie C, Wang S, Guo C, Liu Y, Zeng M. | 12/6/2023 |
| Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals. | Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals.
Pinson A, Xing L, Namba T, Kalebic N, Peters J, Oegema CE, Traikov S, Reppe K, Riesenberg S, Maricic T, Derihaci R, Wimberger P, Pääbo S, Huttner WB. | 09/24/2022 |
| TKTL1 Knockdown Impairs Hypoxia-Induced Glucose-6-phosphate Dehydrogenase and Glyceraldehyde-3-phosphate Dehydrogenase Overexpression. | TKTL1 Knockdown Impairs Hypoxia-Induced Glucose-6-phosphate Dehydrogenase and Glyceraldehyde-3-phosphate Dehydrogenase Overexpression.
Baptista I, Karakitsou E, Cazier JB, Günther UL, Marin S, Cascante M., Free PMC Article | 04/30/2022 |
| High TKTL1 expression as a sign of poor prognosis in colorectal cancer with synchronous rather than metachronous liver metastases. | High TKTL1 expression as a sign of poor prognosis in colorectal cancer with synchronous rather than metachronous liver metastases.
Peltonen R, Ahopelto K, Hagström J, Böckelman C, Haglund C, Isoniemi H., Free PMC Article | 10/23/2021 |
| CircDUSP16 Contributes to Cell Development in Esophageal Squamous Cell Carcinoma by Regulating miR-497-5p/TKTL1 Axis. | CircDUSP16 Contributes to Cell Development in Esophageal Squamous Cell Carcinoma by Regulating miR-497-5p/TKTL1 Axis.
Ma L, Li H, Lin Y, Wang G, Xu Q, Chen Y, Xiao K, Rao X. | 09/11/2021 |
| Use of AKR1C1 and TKTL1 in the Diagnosis of Low-grade Squamous Intraepithelial Lesions from Mexican Women. | Use of AKR1C1 and TKTL1 in the Diagnosis of Low-grade Squamous Intraepithelial Lesions from Mexican Women.
Sequeda-JuÁrez A, JimÉnez A, Espinosa-Montesinos A, Del Carmen Cardenas-Aguayo M, RamÓn-Gallegos E. | 11/21/2020 |
| Transketolase-Like Protein 1 and Glucose Transporter 1 in Gastric Cancer. | Transketolase-Like Protein 1 and Glucose Transporter 1 in Gastric Cancer.
Ahopelto K, Laitinen A, Hagström J, Böckelman C, Haglund C. | 09/19/2020 |
| For the first time we analyzed Apo10 and TKLT1 in patients with cholangiocellular (CCC), pancreatic (PC), and colorectal carcinoma (CRC). | Biomarkers Apo10 and TKTL1: Epitope-detection in monocytes (EDIM) as a new diagnostic approach for cholangiocellular, pancreatic and colorectal carcinoma.
Saman S, Stagno MJ, Warmann SW, Malek NP, Plentz RR, Schmid E., Free PMC Article | 06/13/2020 |
| Homology modelling of TKTL1 and TKTL2 using transketolase (TKT) as template, revealed that both could assume a folded structure like TKT. TKTL1/2 presented a cleft of suitable dimensions between the homodimer surfaces that could accommodate the co-factor-substrate. An appropriate cavity and a hydrophobic nodule were also present in TKTL1/2 and implicated in aminopyrimidine and thiazole ring binding in TKT, respectively. | The human transketolase-like proteins TKTL1 and TKTL2 are bona fide transketolases.
Deshpande GP, Patterton HG, Faadiel Essop M., Free PMC Article | 12/21/2019 |
| The results obtained in this study suggest that pentose phosphate pathway and its key enzyme TKTL1 is altered throughout the prostate cancer tumorigenesis | Transketolase like 1 (TKTL1) expression alterations in prostate cancer tumorigenesis.
da Costa IA, Hennenlotter J, Stühler V, Kühs U, Scharpf M, Todenhöfer T, Stenzl A, Bedke J. | 12/22/2018 |
| Inhibition of TKTL1 expression reverses paclitaxel resistance in human ovarian cancer cells and reduces cell proliferation. | TKTL1 modulates the response of paclitaxel-resistant human ovarian cancer cells to paclitaxel.
Zheng X, Li H. | 12/22/2018 |
| The research provides evidence that TKTL1 renders tumor cells more resistant to radiation therapy and to hypoxic conditions. | Gene Suppression of Transketolase-Like Protein 1 (TKTL1) Sensitizes Glioma Cells to Hypoxia and Ionizing Radiation.
Heller S, Maurer GD, Wanka C, Hofmann U, Luger AL, Bruns I, Steinbach JP, Rieger J., Free PMC Article | 11/24/2018 |
| Knockdown of TKTL1 additively complements cisplatin-induced cytotoxicity in the nasopharyngeal carcinoma cells by inhibiting the levels of NADPH and ribose-5-phosphate, indicating that TKTL1 may be a promising target to improve the therapeutic effect combining with cisplatin for the patients with nasopharyngeal carcinoma. | Knockdown of TKTL1 additively complements cisplatin-induced cytotoxicity in nasopharyngeal carcinoma cells by regulating the levels of NADPH and ribose-5-phosphate.
Dong Y, Wang M. | 02/18/2017 |
| We show that high TKTL1 in tumor tissue can lead to poor survival in colorectal cancer. TKTL1 thus can serve as a candidate marker for identifying patients at risk of recurrent disease | Transketolase-like protein 1 expression predicts poor prognosis in colorectal cancer.
Ahopelto K, Böckelman C, Hagström J, Koskensalo S, Haglund C., Free PMC Article | 12/17/2016 |
| Data provide evidence for an important role of TKTL1 in aerobic glycolysis and tumor promotion in melanoma that may result from defective promoter methylation. | Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells.
Jayachandran A, Lo PH, Chueh AC, Prithviraj P, Molania R, Davalos-Salas M, Anaka M, Walkiewicz M, Cebon J, Behren A., Free PMC Article | 11/5/2016 |
| the cytoplasmatic expression of TKTL1 is specific for MIBC tissue compared with histopathologically benign urothelium. | Expression patterns and prognostic role of transketolase-like 1 in muscle-invasive bladder cancer.
Semilia M, Hennenlotter J, Pavone C, Bischoff T, Kühs U, Gakis G, Bedke J, Stenzl A, Schwentner C, Todenhöfer T. | 07/30/2016 |
| Both TKTL1 and p63 are independent prognostic factors of the poor outcome of gastric cancer patients | TKTL1 and p63 are biomarkers for the poor prognosis of gastric cancer patients.
Song Y, Liu D, He G. | 07/16/2016 |
| TKTL1 is associated with a more aggressive behavior in human esophageal squamous cell carcinoma cells | TKTL1 promotes cell proliferation and metastasis in esophageal squamous cell carcinoma.
Li J, Zhu SC, Li SG, Zhao Y, Xu JR, Song CY. | 06/11/2016 |
| Data revealed exceptional occurrence of TKTL1 in a panel of malignant human cell lines in vitro suggesting that its presence was unrelated to either the rate of glucose consumption/lactic acid production or resistance against chemo- and radiotherapy. | TKTL1 expression in human malign and benign cell lines.
Kämmerer U, Gires O, Pfetzer N, Wiegering A, Klement RJ, Otto C., Free PMC Article | 04/30/2016 |
| our results suggest that TKTL1 as a key prognostic factor may be a novel target for therapy of the patients with esophageal squamous cell carcinoma. | TKTL1 expression and its downregulation is implicated in cell proliferation inhibition and cell cycle arrest in esophageal squamous cell carcinoma.
Shi Z, Tang Y, Li K, Fan Q. | 04/9/2016 |
| In 50% of colorectal cancer patients, TKTL1 protein expression was upregulated in tumor compared to non-tumor tissue. TKTL1 expression correlated with HIF-1alpha protein expression and was induced upon hypoxic conditions. | Hypoxia induces the expression of transketolase-like 1 in human colorectal cancer.
Bentz S, Cee A, Endlicher E, Wojtal KA, Naami A, Pesch T, Lang S, Schubert P, Fried M, Weber A, Coy JF, Goelder S, Knüchel R, Hausmann M, Rogler G. | 08/9/2014 |
| TKTL1 expression levels appear to decline in the course of CML with lowest levels during blast crisis. A potential reason is a shift of TKTL1-high-expressing mature granulocytes towards TKTL1-low-expressing immature cells and blasts. | Expression of transketolase-like gene 1 (TKTL1) depends on disease phase in patients with chronic myeloid leukaemia (CML).
Philipp M, Schwaab J, Dietz CT, Hanfstein B, Kalmanti L, Munjal U, Mossner M, Nowak D, Seifarth W, Hofmann WK, Hochhaus A, Müller MC, Erben P. | 04/12/2014 |
| DNASEX and TKTL1 detection in patient blood is associated with poor disease-free survival rate in oral squamous cell carcinoma. | A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells.
Grimm M, Schmitt S, Teriete P, Biegner T, Stenzl A, Hennenlotter J, Muhs HJ, Munz A, Nadtotschi T, König K, Sänger J, Feyen O, Hofmann H, Reinert S, Coy JF., Free PMC Article | 03/22/2014 |
| EDIM-TKTL1 blood test revealed good concordance with FDG-PET/CT results in patients with malignancies demonstrating its efficacy to detect upregulation of glucose metabolism in primary tumors or metastases. | EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignancies.
Feyen O, Coy JF, Prasad V, Schierl R, Saenger J, Baum RP. | 05/25/2013 |
| Data indicate that transketolase (hTKT). shares 61% sequence identity with transketolase-like protein (TKTL1). | Is transketolase-like protein, TKTL1, transketolase?
Meshalkina LE, Drutsa VL, Koroleva ON, Solovjeva ON, Kochetov GA. | 05/11/2013 |