| Molecular and in silico analyses of SYN III gene variants in autism spectrum disorder. | Molecular and in silico analyses of SYN III gene variants in autism spectrum disorder.
Baris RO, Sahin N, Bilgic AD, Ozdemir C, Edgunlu TG. | 12/5/2023 |
| Investigation of possible associations of the BDNF, SNAP-25 and SYN III genes with the neurocognitive measures: BDNF and SNAP-25 genes might be involved in attention domain, SYN III gene in executive function. | Investigation of possible associations of the BDNF, SNAP-25 and SYN III genes with the neurocognitive measures: BDNF and SNAP-25 genes might be involved in attention domain, SYN III gene in executive function.
Bolat H, Ünsel-Bolat G, Özgül S, Parıltay E, Tahıllıoğlu A, Rohde LA, Akın H, Ercan ES. | 11/12/2022 |
| Synapsin III is a crucial alpha-synuclein interactant and a key component of Lewy bodies fibrils in the brain of patients affected by Parkinson's disease. | Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains.
Longhena F, Faustini G, Varanita T, Zaltieri M, Porrini V, Tessari I, Poliani PL, Missale C, Borroni B, Padovani A, Bubacco L, Pizzi M, Spano P, Bellucci A., Free PMC Article | 06/1/2019 |
| These findings contribute to previous work showing dysregulation of Synapsins, particularly SYN2, in mood disorders and improve our understanding of the regulatory mechanisms that precipitate these changes likely leading to the BD or MDD phenotype. | DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression.
Cruceanu C, Kutsarova E, Chen ES, Checknita DR, Nagy C, Lopez JP, Alda M, Rouleau GA, Turecki G., Free PMC Article | 06/10/2017 |
| Syn-3 may mimic Syn-1A in the ability to bind and modulate Cavs, but preferring Cav2.3 to perhaps participate in triggering fusion of newcomer insulin SGs during second-phase GSIS. | Syntaxin-3 Binds and Regulates Both R- and L-Type Calcium Channels in Insulin-Secreting INS-1 832/13 Cells.
Xie L, Dolai S, Kang Y, Liang T, Xie H, Qin T, Yang L, Chen L, Gaisano HY., Free PMC Article | 07/16/2016 |
| These findings support a reciprocal modulatory interaction of alpha-syn and synapsin III in the regulation of dopamine neuron synaptic function. | α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons.
Zaltieri M, Grigoletto J, Longhena F, Navarria L, Favero G, Castrezzati S, Colivicchi MA, Della Corte L, Rezzani R, Pizzi M, Benfenati F, Spillantini MG, Missale C, Spano P, Bellucci A. | 04/2/2016 |
| The variations of MnSOD (rs4880) and SYN III (rs3788470, rs3827336, rs5998557) were not major risk factors for PD among Chinese, at least in our study populations | No association of four candidate genetic variants in MnSOD and SYNIII with Parkinson's disease in two Chinese populations.
Yu WJ, Li NN, Tan EK, Cheng L, Zhang JH, Mao XY, Chang XL, Zhao DM, Liao Q, Peng R., Free PMC Article | 01/10/2015 |
| A significant difference was determined between attention deficit hyperactivity disorder and synapsin III gene -631 C>G polymorphism compared to the control group. | Association of synapsin III gene with adult attention deficit hyperactivity disorder.
Kenar AN, Edgünlü T, Herken H, Erdal ME. | 10/19/2013 |
| A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. | Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Martins-de-Souza D, Guest PC, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S. | 04/26/2012 |
| This protein has been found differentially expressed in thalami from patients with schizophrenia. | Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
Martins-de-Souza D, Maccarrone G, Wobrock T, Zerr I, Gormanns P, Reckow S, Falkai P, Schmitt A, Turck CW. | 07/13/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Both the association studies and expression studies didn't support a major role for SYN3 in the susceptibility of schizophrenia in Irish and Chinese populations. | Association and expression study of synapsin III and schizophrenia.
Chen Q, Che R, Wang X, O'Neill FA, Walsh D, Tang W, Shi Y, He L, Kendler KS, Chen X, Chen Q, Che R, Wang X, O'Neill FA, Walsh D, Tang W, Shi Y, He L, Kendler KS, Chen X., Free PMC Articles: PMC2777515, PMC2777515 | 01/21/2010 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L. | 12/2/2009 |
| the C/C genotype in rs133946 and the G/G genotype in rs133945 could be protecting factors against multiple sclerosis in the Basque population. | Association between synapsin III gene promoter SNPs and multiple sclerosis in Basque patients.
Otaegui D, Zuriarrain O, Castillo-Triviño T, Aransay A, Ruíz-Martinez J, Olaskoaga J, Marti-Masso J, Lopez de Munain A, Otaegui D, Zuriarrain O, Castillo-Triviño T, Aransay A, Ruíz-Martinez J, Olaskoaga J, Marti-Masso J, Lopez de Munain A. | 01/21/2010 |
| The variation in SYN III methylation studied is 1) not related to schizophrenia in the population sample or a monozygotic twin pair discordant for schizophrenia and 2) not related to the mRNA level of SYN IIIa in different human brain regions | DNA methylation and mRNA expression of SYN III, a candidate gene for schizophrenia.
Murphy BC, O'Reilly RL, Singh SM., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (9) articlesAn approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Association and expression study of synapsin III and schizophrenia.
Chen Q, Che R, Wang X, O'Neill FA, Walsh D, Tang W, Shi Y, He L, Kendler KS, Chen X, Chen Q, Che R, Wang X, O'Neill FA, Walsh D, Tang W, Shi Y, He L, Kendler KS, Chen X. Association between synapsin III gene promoter SNPs and multiple sclerosis in Basque patients.
Otaegui D, Zuriarrain O, Castillo-Triviño T, Aransay A, Ruíz-Martinez J, Olaskoaga J, Marti-Masso J, Lopez de Munain A, Otaegui D, Zuriarrain O, Castillo-Triviño T, Aransay A, Ruíz-Martinez J, Olaskoaga J, Marti-Masso J, Lopez de Munain A. The gene for synapsin III and attention-deficit hyperactivity disorder.
Makkar R, Gomez L, Wigg KG, Ickowicz A, Pathare T, Tannock R, Malone M, Kennedy JL, Schachar R, Barr CL, Makkar R, Gomez L, Wigg KG, Ickowicz A, Pathare T, Tannock R, Malone M, Kennedy JL, Schachar R, Barr CL. Potential genetic variants in schizophrenia: a Bayesian analysis.
Hall H, Lawyer G, Sillén A, Jönsson EG, Agartz I, Terenius L, Arnborg S. Analysis of synapsin III-196 promoter mutation in schizophrenia and bipolar disorder.
Lachman HM, Stopkova P, Papolos DF, Pedrosa E, Margolis B, Aghalar MR, Saito T, Lachman HM, Stopkova P, Papolos DF, Pedrosa E, Margolis B, Aghalar MR, Saito T. Association of schizophrenia in African Americans to polymorphism in synapsin III gene.
Lachman HM, Stopkova P, Rafael MA, Saito T, Lachman HM, Stopkova P, Rafael MA, Saito T. Mutation analysis of synapsin III gene in schizophrenia.
Tsai MT, Hung CC, Tsai CY, Liu MY, Su YC, Chen YH, Hsiao KJ, Chen CH, Tsai MT, Hung CC, Tsai CY, Liu MY, Su YC, Chen YH, Hsiao KJ, Chen CH. | 03/13/2008 |
| No evidence that the synapsin III locus as a major susceptibility locus contributing to attention deficit hyperactivity disorder. | The gene for synapsin III and attention-deficit hyperactivity disorder.
Makkar R, Gomez L, Wigg KG, Ickowicz A, Pathare T, Tannock R, Malone M, Kennedy JL, Schachar R, Barr CL, Makkar R, Gomez L, Wigg KG, Ickowicz A, Pathare T, Tannock R, Malone M, Kennedy JL, Schachar R, Barr CL. | 01/21/2010 |
| Supports a role for synapsin III in a subset of African American patients with schizophrenia. | Association of schizophrenia in African Americans to polymorphism in synapsin III gene.
Lachman HM, Stopkova P, Rafael MA, Saito T, Lachman HM, Stopkova P, Rafael MA, Saito T. | 01/21/2010 |
| A trend towards significance was detected when the synapsin III -196A allele distribution was analyzed in Caucasian patients with schizophrenia and a cohort of subjects from the Czech Republic with bipolar disorder. | Analysis of synapsin III-196 promoter mutation in schizophrenia and bipolar disorder.
Lachman HM, Stopkova P, Papolos DF, Pedrosa E, Margolis B, Aghalar MR, Saito T, Lachman HM, Stopkova P, Papolos DF, Pedrosa E, Margolis B, Aghalar MR, Saito T. | 01/21/2010 |
| A missense polymorphism, S470N, was identified in the synapsin III gene and appeared more frequently in individuals with schizophrenia. The site affected by the polymorphism, Ser470, was determined to be a substrate for mitogen-activated protein kinase. | A rare polymorphism affects a mitogen-activated protein kinase site in synapsin III: possible relationship to schizophrenia.
Porton B, Ferreira A, DeLisi LE, Kao HT. | 01/21/2010 |
| Evidence is not in favor of a large effect of synapsin III gene in the pathogenesis of schizophrenia. | Mutation analysis of synapsin III gene in schizophrenia.
Tsai MT, Hung CC, Tsai CY, Liu MY, Su YC, Chen YH, Hsiao KJ, Chen CH, Tsai MT, Hung CC, Tsai CY, Liu MY, Su YC, Chen YH, Hsiao KJ, Chen CH. | 01/21/2010 |