| PON2 ameliorates Ang II-induced cardiomyocyte injury by targeting the CANX/NOX4 signaling pathway. | PON2 ameliorates Ang II-induced cardiomyocyte injury by targeting the CANX/NOX4 signaling pathway.
Ye Y, Zhang J, Guo Y, Zhu J, Tang B, Fan P., Free PMC Article | 02/28/2023 |
| KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity. | KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
Yan G, Li X, Zheng Z, Gao W, Chen C, Wang X, Cheng Z, Yu J, Zou G, Farooq MZ, Zhu X, Zhu W, Zhong Q, Yan X., Free PMC Article | 11/26/2022 |
| A Chaperone-Like Role for EBI3 in Collaboration With Calnexin Under Inflammatory Conditions. | A Chaperone-Like Role for EBI3 in Collaboration With Calnexin Under Inflammatory Conditions.
Watanabe A, Mizoguchi I, Hasegawa H, Katahira Y, Inoue S, Sakamoto E, Furusaka Y, Sekine A, Miyakawa S, Murakami F, Xu M, Yoneto T, Yoshimoto T., Free PMC Article | 03/19/2022 |
| Circulating small extracellular vesicles increase after an acute bout of moderate-intensity exercise in pregnant compared to non-pregnant women. | Circulating small extracellular vesicles increase after an acute bout of moderate-intensity exercise in pregnant compared to non-pregnant women.
Mohammad S, Hutchinson KA, da Silva DF, Bhattacharjee J, McInnis K, Burger D, Adamo KB., Free PMC Article | 11/6/2021 |
| The Role of Cardiolipin as a Scaffold Mitochondrial Phospholipid in Autophagosome Formation: In Vitro Evidence. | The Role of Cardiolipin as a Scaffold Mitochondrial Phospholipid in Autophagosome Formation: In Vitro Evidence.
Manganelli V, Capozzi A, Recalchi S, Riitano G, Mattei V, Longo A, Misasi R, Garofalo T, Sorice M., Free PMC Article | 07/3/2021 |
| Ca(2+) Regulates ERp57-Calnexin Complex Formation. | Ca(2+) Regulates ERp57-Calnexin Complex Formation.
Tanikawa Y, Kanemura S, Ito D, Lin Y, Matsusaki M, Kuroki K, Yamaguchi H, Maenaka K, Lee YH, Inaba K, Okumura M., Free PMC Article | 06/26/2021 |
| Calnexin mediates the maturation of GPI-anchors through ER retention. | Calnexin mediates the maturation of GPI-anchors through ER retention.
Guo XY, Liu YS, Gao XD, Kinoshita T, Fujita M., Free PMC Article | 03/13/2021 |
| ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells. | ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells.
Ros M, Nguyen AT, Chia J, Le Tran S, Le Guezennec X, McDowall R, Vakhrushev S, Clausen H, Humphries MJ, Saltel F, Bard FA. | 02/2/2021 |
| Calnexin accelerates the folding of the mucopolysaccharidosis type II mutant IDS in the endoplasmic reticulum. | Calnexin promotes the folding of mutant iduronate 2-sulfatase related to mucopolysaccharidosis type II.
Osaki Y, Matsuhisa K, Che W, Kaneko M, Asada R, Masaki T, Imaizumi K, Saito A. | 07/25/2020 |
| This work uncovers a mechanism by which T-cell antitumor responses are regulated by calnexin in tumor cells and suggests that calnexin might serve as a potential target for the improvement of antitumor immunotherapy. | Calnexin Impairs the Antitumor Immunity of CD4(+) and CD8(+) T Cells.
Chen Y, Ma D, Wang X, Fang J, Liu X, Song J, Li X, Ren X, Li Q, Li Q, Wen S, Luo L, Xia J, Cui J, Zeng G, Chen L, Cheng B, Wang Z. | 03/7/2020 |
| Results provide evidence that calnexin is required for autophagy of procollagen. | A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex.
Forrester A, De Leonibus C, Grumati P, Fasana E, Piemontese M, Staiano L, Fregno I, Raimondi A, Marazza A, Bruno G, Iavazzo M, Intartaglia D, Seczynska M, van Anken E, Conte I, De Matteis MA, Dikic I, Molinari M, Settembre C., Free PMC Article | 12/28/2019 |
| Study discovered that calnexin is highly abundant in human brain endothelial cells of multiple sclerosis (MS) patients. Conversely, mice lacking calnexin exhibited resistance to experimental autoimmune encephalomyelitis induction, no evidence of immune cell infiltration into the CNS. These findings identify a link between calnexin expression in CNS endothelial cells and neuroinflammation. | Calnexin is necessary for T cell transmigration into the central nervous system.
Jung J, Eggleton P, Robinson A, Wang J, Gutowski N, Holley J, Newcombe J, Dudek E, Paul AM, Zochodne D, Kraus A, Power C, Agellon LB, Michalak M., Free PMC Article | 12/7/2019 |
| In summary, ER retention of pathogenic VLDLR mutants involves binding to calnexin, elevated endoplasmic reticulum stress, and delayed degradation which is dependent on SEL1L. | Degradation routes of trafficking-defective VLDLR mutants associated with Dysequilibrium syndrome.
Kizhakkedath P, John A, Al-Gazali L, Ali BR., Free PMC Article | 12/1/2018 |
| Increased tumour protein levels of calnexin may be of prognostic significance in colorectal cancer, and calnexin may represent a potential target for future therapies. | Calnexin, an ER stress-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer.
Ryan D, Carberry S, Murphy ÁC, Lindner AU, Fay J, Hector S, McCawley N, Bacon O, Concannon CG, Kay EW, McNamara DA, Prehn JH., Free PMC Article | 10/21/2017 |
| FUNDC1 integrates mitochondrial fission and mitophagy at the interface of the endoplasmic reticulum-mitochondrial contact site by working in concert with DRP1 and calnexin under hypoxic conditions in mammalian cells. | FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.
Wu W, Lin C, Wu K, Jiang L, Wang X, Li W, Zhuang H, Zhang X, Chen H, Li S, Yang Y, Lu Y, Wang J, Zhu R, Zhang L, Sui S, Tan N, Zhao B, Zhang J, Li L, Feng D., Free PMC Article | 07/1/2017 |
| Results of further analyses by using a CNX mutant imply that ERp29 and ERp57 recognize the same domain of CNX, whereas the mode of interaction with CNX might be somewhat different between them. | PDI family protein ERp29 recognizes P-domain of molecular chaperone calnexin.
Nakao H, Seko A, Ito Y, Sakono M. | 06/24/2017 |
| Inhibit interaction between HIV-1 Nef and Calnexin to reverse HIV-induced lipid accumulation and prevent atherosclerosis. | Interaction Between HIV-1 Nef and Calnexin: From Modeling to Small Molecule Inhibitors Reversing HIV-Induced Lipid Accumulation.
Hunegnaw R, Vassylyeva M, Dubrovsky L, Pushkarsky T, Sviridov D, Anashkina AA, Üren A, Brichacek B, Vassylyev DG, Adzhubei AA, Bukrinsky M., Free PMC Article | 06/24/2017 |
| Endogenous NOX4 forms macromolecular complexes with calnexin, which are needed for the proper maturation, processing, and function of NOX4 in the endoplasmic reticulum. | The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein.
Prior KK, Wittig I, Leisegang MS, Groenendyk J, Weissmann N, Michalak M, Jansen-Dürr P, Shah AM, Brandes RP., Free PMC Article | 08/6/2016 |
| To study principles underlying dynamics and regulation of palmitoylation, the ER chaperone calnexin, which requires dual palmitoylation for function, was investigated. | Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone Calnexin.
Dallavilla T, Abrami L, Sandoz PA, Savoglidis G, Hatzimanikatis V, van der Goot FG., Free PMC Article | 06/11/2016 |
| These observations point at a previously unrecognized contribution of calnexin to the retention of NMT1 at the ER membrane. | N-Myristoyltransferase 1 interacts with calnexin at the endoplasmic reticulum.
Dudek E, Millott R, Liu WX, Beauchamp E, Berthiaume LG, Michalak M. | 04/23/2016 |
| Charcot-Marie-Tooth disease-related PMP22 is trapped in the endoplasmic reticulum by calnexin-dependent retention and Rer1-mediated early Golgi retrieval systems and partly degraded by the Hrd1-mediated endoplasmic reticulum-associated degradation system. | Rer1 and calnexin regulate endoplasmic reticulum retention of a peripheral myelin protein 22 mutant that causes type 1A Charcot-Marie-Tooth disease.
Hara T, Hashimoto Y, Akuzawa T, Hirai R, Kobayashi H, Sato K., Free PMC Article | 10/24/2015 |
| Data indicate that protein tyrosine phosphatase 1B (PTP1B) association with calnexin is ubiquitin conjugating enzyme 9 (UBC9)-dependent. | UBC9-dependent association between calnexin and protein tyrosine phosphatase 1B (PTP1B) at the endoplasmic reticulum.
Lee D, Kraus A, Prins D, Groenendyk J, Aubry I, Liu WX, Li HD, Julien O, Touret N, Sykes BD, Tremblay ML, Michalak M., Free PMC Article | 05/16/2015 |
| H-ERG trafficking was impaired by H2O2 after 48 h treatment, accompanied by reciprocal changes of expression between miR-17-5p seed miRNAs and several chaperones (Hsp70, Hsc70, CANX, and Golga20) | MiR-17-5p impairs trafficking of H-ERG K+ channel protein by targeting multiple er stress-related chaperones during chronic oxidative stress.
Wang Q, Hu W, Lei M, Wang Y, Yan B, Liu J, Zhang R, Jin Y., Free PMC Article | 02/28/2015 |
| Nef regulates the activity of calnexin to stimulate its interaction with gp160 at the expense of ABCA1 | HIV-1 protein Nef inhibits activity of ATP-binding cassette transporter A1 by targeting endoplasmic reticulum chaperone calnexin.
Jennelle L, Hunegnaw R, Dubrovsky L, Pushkarsky T, Fitzgerald ML, Sviridov D, Popratiloff A, Brichacek B, Bukrinsky M., Free PMC Article | 12/27/2014 |
| The impact of CANX genetic variants to heart rate was discovered. | Insight into genetic determinants of resting heart rate.
Mezzavilla M, Iorio A, Bobbo M, D'Eustacchio A, Merlo M, Gasparini P, Ulivi S, Sinagra G. | 08/30/2014 |