| The effect of Par3 on the cellular junctions and biological functions of odontoblast-lineage cells. | The effect of Par3 on the cellular junctions and biological functions of odontoblast-lineage cells.
Wang J, Cheng X, Mei X, Wu H, Yu Q, Xiao M. | 01/10/2024 |
| Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells. | Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells.
Valdivia A, Cárdenas A, Brenet M, Maldonado H, Kong M, Díaz J, Burridge K, Schneider P, San Martín A, García-Mata R, Quest AFG, Leyton L., Free PMC Article | 08/14/2021 |
| Phosphorylation of Dab2 is involved in inhibited VEGF-VEGFR-2 signaling induced by downregulation of syndecan-1 in glomerular endothelial cell. | Phosphorylation of Dab2 is involved in inhibited VEGF-VEGFR-2 signaling induced by downregulation of syndecan-1 in glomerular endothelial cell.
Jing Z, Jia-Jun W, Wei-Jie Y. | 10/3/2020 |
| identify ASPP2 as a regulator of Par-3, which plays a key role in controlling cell proliferation, polarity, and tissue organization during CNS development | ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development.
Sottocornola R, Royer C, Vives V, Tordella L, Zhong S, Wang Y, Ratnayaka I, Shipman M, Cheung A, Gaston-Massuet C, Ferretti P, Molnár Z, Lu X. | 05/13/2019 |
| results identify a dual function of Par3 in skin cancer, with both pro-oncogenic and tumor-suppressive activity depending on the tumor type | Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis.
Iden S, van Riel WE, Schäfer R, Song JY, Hirose T, Ohno S, Collard JG. | 05/13/2019 |
| Par3 emerges as a key molecule in the coupling of the early and late events needed for efficient extraction and processing of immobilized antigen by B-cells. | Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse.
Reversat A, Yuseff MI, Lankar D, Malbec O, Obino D, Maurin M, Penmatcha NV, Amoroso A, Sengmanivong L, Gundersen GG, Mellman I, Darchen F, Desnos C, Pierobon P, Lennon-Duménil AM., Free PMC Article | 05/13/2019 |
| transcriptional upregulation of Girdin expression and Girdin-Galphai3 signaling play crucial roles in regulating epithelial apicobasal polarity through the PAR complex. | Regulation of epithelial cell polarity by PAR-3 depends on Girdin transcription and Girdin-Gαi3 signaling.
Sasaki K, Kakuwa T, Akimoto K, Koga H, Ohno S. | 04/2/2016 |
| PAR3 interacts with PAR6 and NGL-2, acting together to regulate axon differentiation. | NGL-2 Is a New Partner of PAR Complex in Axon Differentiation.
Xu G, Wang R, Wang Z, Lei Q, Yu Z, Liu C, Li P, Yang Z, Cheng X, Li G, Wu M., Free PMC Article | 07/25/2015 |
| Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein. | Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
Tep C, Kim ML, Opincariu LI, Limpert AS, Chan JR, Appel B, Carter BD, Yoon SO., Free PMC Article | 03/3/2012 |
| Report a willin(FRMD6)/Par3-aPKC-ROCK pathway that controls epithelial apical morphology. | Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation.
Ishiuchi T, Takeichi M. | 09/10/2011 |
| These data suggest that the putative phospholipid binding by par-3 is important for its localization at cell-cell junctions. | Phosphoinositide binding by par-3 involved in par-3 localization.
Horikoshi Y, Hamada S, Ohno S, Suetsugu S. | 08/27/2011 |
| up-regulation of miR-491-5p contributes to TGF-beta-regulated Par-3 expression. | TGF-{beta}-induced MiR-491-5p expression promotes Par-3 degradation in rat proximal tubular epithelial cells.
Zhou Q, Fan J, Ding X, Peng W, Yu X, Chen Y, Nie J., Free PMC Article | 01/15/2011 |
| Data show that Aurora A interacts directly with the atypical protein kinase C binding domain of Par3 and phosphorylates it at serine 962. | Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora a and regulates its function in neuronal polarity.
Khazaei MR, Püschel AW., Free PMC Article | 01/25/2010 |
| Results identify a new role for local translation and the PAR complex in axonal outgrowth. | Axonal elongation triggered by stimulus-induced local translation of a polarity complex protein.
Hengst U, Deglincerti A, Kim HJ, Jeon NL, Jaffrey SR., Free PMC Article | 01/21/2010 |
| RalA and the exocyst complex influence neuronal polarity through PAR-3 and aPKC. | RalA and the exocyst complex influence neuronal polarity through PAR-3 and aPKC.
Lalli G. | 01/21/2010 |
| Par-3 functions as a scaffold in integrating phosphoinositide signaling events during cellular polarization | Par-3-mediated junctional localization of the lipid phosphatase PTEN is required for cell polarity establishment.
Feng W, Wu H, Chan LN, Zhang M. | 01/21/2010 |
| the Par6/Par3-based polarity complex likely coordinates the events of apical ectoplasmic specialization and blood-testis barrier restructuring that take place concurrently at the opposing ends of adjacent Sertoli cells during spermatogenesis | Par3/Par6 polarity complex coordinates apical ectoplasmic specialization and blood-testis barrier restructuring during spermatogenesis.
Wong EW, Mruk DD, Lee WM, Cheng CY., Free PMC Article | 01/21/2010 |
| downregulation of Par-3 and subsequent disruption of Par complex integrity might be one mechanism that TGF-beta destroys cell polarity during epithelial to mesenchymal transition | Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-beta during the process of epithelial to mesenchymal transition in rat proximal epithelial cells.
Wang X, Nie J, Zhou Q, Liu W, Zhu F, Chen W, Mao H, Luo N, Dong X, Yu X. | 01/21/2010 |
| The Par-3 N-terminal oligomerization domain adopts a PB1-like structure required for Par-3 oligomerization and membrane localization. | The Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localization.
Feng W, Wu H, Chan LN, Zhang M., Free PMC Article | 01/21/2010 |
| Par-3 localizes asymmetrically in Schwann cells at the axon-glial junction; disruption of Par-3 localization inhibits myelination; Par-3 associates & recruits p75 neurotrophin receptor to the axon-glial junction forming a complex needed for myelination | The polarity protein Par-3 directly interacts with p75NTR to regulate myelination.
Chan JR, Jolicoeur C, Yamauchi J, Elliott J, Fawcett JP, Ng BK, Cayouette M. | 01/21/2010 |
| PAR-6-PAR-3 complex mediates Cdc42-induced Rac activation by means of STEF/Tiam1 | PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
Nishimura T, Yamaguchi T, Kato K, Yoshizawa M, Nabeshima Y, Ohno S, Hoshino M, Kaibuchi K. | 01/21/2010 |
| the CR1-mediated self-association of the PAR-3-containing protein complex plays a role during the formation of functional tight junctions. | Self-association of PAR-3-mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions.
Mizuno K, Suzuki A, Hirose T, Kitamura K, Kutsuzawa K, Futaki M, Amano Y, Ohno S. | 01/21/2010 |
| PAR-3 regulates spine formation by binding the Rac guanine nucleotide-exchange factor (GEF) TIAM1, and spatially restricting it to dendritic spines. | The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis.
Zhang H, Macara IG. | 01/21/2010 |