| SUMOylation of RNF146 results in Axin degradation and activation of Wnt/beta-catenin signaling to promote the progression of hepatocellular carcinoma. | SUMOylation of RNF146 results in Axin degradation and activation of Wnt/β-catenin signaling to promote the progression of hepatocellular carcinoma.
Li W, Han Q, Zhu Y, Zhou Y, Zhang J, Wu W, Li Y, Liu L, Qiu Y, Hu K, Yin D. | 05/25/2023 |
| Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation. | Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
Xu YR, Shi ML, Zhang Y, Kong N, Wang C, Xiao YF, Du SS, Zhu QY, Lei CQ., Free PMC Article | 07/2/2022 |
| Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs. | Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.
Chandrakumar AA, Coyaud É, Marshall CB, Ikura M, Raught B, Rottapel R., Free PMC Article | 10/9/2021 |
| Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation. | Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation.
Nie L, Wang C, Li N, Feng X, Lee N, Su D, Tang M, Yao F, Chen J., Free PMC Article | 08/14/2021 |
| Rhododendrin is cytoprotective against 6-hydroxydopamine (6-OHDA)-induced cell death, which is largely dependent on ERbeta activity and RNF146 expression. | Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress.
Kim H, Park J, Leem H, Cho M, Yoon JH, Maeng HJ, Lee Y., Free PMC Article | 08/3/2019 |
| RNF146 exerted oncogenic role through ubiquitination of Axin1 to activate beta-catenin signaling. | The E3 ubiquitin ligase RNF146 promotes colorectal cancer by activating the Wnt/β-catenin pathway via ubiquitination of Axin1.
Shen J, Yu Z, Li N. | 12/22/2018 |
| Iduna expression under disruptive neurohomeostasis (e.g., uncompensated oxidative stress or ischemic stroke after MCAo) is upregulated by neuroprotectin D1 and thus serves as a key regulator of cell survival, halting neural cell death. | Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke.
Belayev L, Mukherjee PK, Balaszczuk V, Calandria JM, Obenaus A, Khoutorova L, Hong SH, Bazan NG., Free PMC Article | 03/31/2018 |
| the maintenance of unliganded RNF146 in an inactive state may serve to maintain the stability of the RNF146-TNKS complex, which in turn regulates the homeostasis of PARylation-dependent ubiquitination activity in the cell | Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
DaRosa PA, Wang Z, Jiang X, Pruneda JN, Cong F, Klevit RE, Xu W., Free PMC Article | 02/21/2015 |
| RNF146 regulated the development and progression of NSCLC | Overexpression of RNF146 in non-small cell lung cancer enhances proliferation and invasion of tumors through the Wnt/β-catenin signaling pathway.
Gao Y, Song C, Hui L, Li CY, Wang J, Tian Y, Han X, Chen Y, Tian DL, Qiu X, Wang E., Free PMC Article | 09/20/2014 |
| Iduna is a Poly(ADP-ribose)-dependent ubiquitin E3 ligase. | Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.
Kang HC, Lee YI, Shin JH, Andrabi SA, Chi Z, Gagné JP, Lee Y, Ko HS, Lee BD, Poirier GG, Dawson VL, Dawson TM., Free PMC Article | 09/14/2012 |
| RNF146/Iduna has been found to be implicated in neurodegenerative disease and cancer development. [Review] | Ring finger protein 146/Iduna is a poly(ADP-ribose) polymer binding and PARsylation dependent E3 ubiquitin ligase.
Zhou ZD, Chan CH, Xiao ZC, Tan EK., Free PMC Article | 05/19/2012 |
| the RNF146 WWE domain recognizes poly(ADP-ribose) (PAR) by interacting with iso-ADP-ribose (iso-ADPR), the smallest internal PAR structural unit containing the characteristic ribose-ribose glycosidic bond formed during poly(ADP-ribosyl)ation. | Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination.
Wang Z, Michaud GA, Cheng Z, Zhang Y, Hinds TR, Fan E, Cong F, Xu W., Free PMC Article | 03/17/2012 |
| RNF146 RING-type ubiquitin E3 ligase as a positive regulator of Wnt signaling that operates with tankyrase to maintain low steady-state levels of Axin proteins | Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.
Callow MG, Tran H, Phu L, Lau T, Lee J, Sandoval WN, Liu PS, Bheddah S, Tao J, Lill JR, Hongo JA, Davis D, Kirkpatrick DS, Polakis P, Costa M., Free PMC Article | 12/10/2011 |
| Mutations in the coding regions of the RNF146 and ECHDC1 genes do not contribute to the burden of inherited predisposition of breast cancer in Ashkenazi high risk women. | The RNF146 and ECHDC1 genes as candidates for inherited breast and ovarian cancer in Jewish Ashkenazi women.
Menachem TD, Laitman Y, Kaufman B, Friedman E, Menachem TD, Laitman Y, Kaufman B, Friedman E. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | The RNF146 and ECHDC1 genes as candidates for inherited breast and ovarian cancer in Jewish Ashkenazi women.
Menachem TD, Laitman Y, Kaufman B, Friedman E, Menachem TD, Laitman Y, Kaufman B, Friedman E. | 06/24/2009 |
| Genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.
Gold B, Kirchhoff T, Stefanov S, Lautenberger J, Viale A, Garber J, Friedman E, Narod S, Olshen AB, Gregersen P, Kosarin K, Olsh A, Bergeron J, Ellis NA, Klein RJ, Clark AG, Norton L, Dean M, Boyd J, Offit K., Free PMC Article | 04/3/2008 |
| Dactylidin may function early in the progression of Alzheimer's disease. | The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease.
von Rotz RC, Kins S, Hipfel R, von der Kammer H, Nitsch RM. | 01/21/2010 |