| NETO2 promotes melanoma progression via activation of the Ca[2+]/CaMKII signaling pathway. | NETO2 promotes melanoma progression via activation of the Ca(2+)/CaMKII signaling pathway.
Zhu S, Zhang X, Guo Y, Tang L, Zhou Z, Chen X, Peng C. | 06/2/2023 |
| Ca[2+]/Calmodulin-Dependent Protein Kinase II Disrupts the Voltage Dependency of the Voltage-Dependent Anion Channel on the Lipid Bilayer Membrane. | Ca(2+)/Calmodulin-Dependent Protein Kinase II Disrupts the Voltage Dependency of the Voltage-Dependent Anion Channel on the Lipid Bilayer Membrane.
Koren DT, Shrivastava R, Ghosh S. | 04/21/2023 |
| Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1alpha mRNA. | Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA.
Gurd BJ, Menezes ES, Arhen BB, Islam H. | 03/14/2023 |
| CAMK2G is identified as a novel therapeutic target for myelofibrosis. | CAMK2G is identified as a novel therapeutic target for myelofibrosis.
Miyauchi M, Sasaki K, Kagoya Y, Taoka K, Masamoto Y, Yamazaki S, Arai S, Mizuno H, Kurokawa M., Free PMC Article | 07/30/2022 |
| Matrine suppresses cell growth of diffuse large B-cell lymphoma via inhibiting CaMKIIgamma/c-Myc/CDK6 signaling pathway. | Matrine suppresses cell growth of diffuse large B-cell lymphoma via inhibiting CaMKIIγ/c-Myc/CDK6 signaling pathway.
Gu J, Wang X, Zhang L, Xiang J, Li J, Chen Z, Zhang Y, Chen J, Shen J., Free PMC Article | 12/25/2021 |
| A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII. | A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII.
López X, Palacios-Prado N, Güiza J, Escamilla R, Fernández P, Vega JL, Rojas M, Marquez-Miranda V, Chamorro E, Cárdenas AM, Maldifassi MC, Martínez AD, Duarte Y, González-Nilo FD, Sáez JC., Free PMC Article | 12/18/2021 |
| CaMKIIgamma regulates the viability and self-renewal of acute myeloid leukaemia stem-like cells by the Alox5/NF-kappaB pathway. | CaMKIIγ regulates the viability and self-renewal of acute myeloid leukaemia stem-like cells by the Alox5/NF-κB pathway.
Cheng JH, Zhang WJ, Zhu JF, Cui D, Song KD, Qiang P, Mei CZ, Nie ZC, Ding BS, Han Z, Ding ZE, Zheng WW. | 08/28/2021 |
| CaMKII Phosphorylation Regulates Synaptic Enrichment of Shank3. | CaMKII Phosphorylation Regulates Synaptic Enrichment of Shank3.
Jeong J, Li Y, Roche KW., Free PMC Article | 07/24/2021 |
| CaMK II/Ca2+ dependent endoplasmic reticulum stress mediates apoptosis of hepatic stellate cells stimulated by transforming growth factor beta 1. | CaMK II/Ca2+ dependent endoplasmic reticulum stress mediates apoptosis of hepatic stellate cells stimulated by transforming growth factor beta 1.
Liu H, Wang L, Dai L, Feng F, Xiao Y. | 05/1/2021 |
| CAMKIIgamma is a targetable driver of multiple myeloma through CaMKIIgamma/ Stat3 axis. | CAMKIIγ is a targetable driver of multiple myeloma through CaMKIIγ/ Stat3 axis.
Yang L, Wu B, Wu Z, Xu Y, Wang P, Li M, Xu R, Liang Y., Free PMC Article | 03/13/2021 |
| CaMKII and GLUT1 in heart failure and the role of gliflozins. | CaMKII and GLUT1 in heart failure and the role of gliflozins.
Trum M, Wagner S, Maier LS, Mustroph J. | 10/24/2020 |
| The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation. | The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation.
Fujii S, Tajiri Y, Hasegawa K, Matsumoto S, Yoshimoto RU, Wada H, Kishida S, Kido MA, Yoshikawa H, Ozeki S, Kiyoshima T. | 09/26/2020 |
| CaMKII/proteasome/cytosolic calcium/cathepsin B axis was present in tryspin activation induced by nicardipine. | CaMKII/proteasome/cytosolic calcium/cathepsin B axis was present in tryspin activation induced by nicardipine.
Xiao J, Lin H, Liu B, Jin J., Free PMC Article | 09/12/2020 |
| Ca2+-activated Cl- channels encoded by the Tmem16a gene are regulated by calmodulin-dependent protein kinase II (CaMKII) and protein phosphatases 1 (PP1) and 2A (PP2A). | Molecular mechanism of TMEM16A regulation: role of CaMKII and PP1/PP2A.
Ayon RJ, Hawn MB, Aoun J, Wiwchar M, Forrest AS, Cunningham F, Singer CA, Valencik ML, Greenwood IA, Leblanc N., Free PMC Article | 04/11/2020 |
| BAFF promotes B-cell proliferation and survival by inhibiting autophagy. BAFF inhibits autophagy by activating Ca2+-CaMKII-dependent Akt/mTOR signaling pathway in B cells. | BAFF inhibits autophagy promoting cell proliferation and survival by activating Ca(2+)-CaMKII-dependent Akt/mTOR signaling pathway in normal and neoplastic B-lymphoid cells.
Dong X, Qin J, Ma J, Zeng Q, Zhang H, Zhang R, Liu C, Xu C, Zhang S, Huang S, Chen L., Free PMC Article | 02/29/2020 |
| mark the CaMKII-delta9-UBE2T-DNA damage pathway as an important therapeutic target for cardiomyopathy and heart failure | CaMKII-δ9 promotes cardiomyopathy through disrupting UBE2T-dependent DNA repair.
Zhang M, Gao H, Liu D, Zhong X, Shi X, Yu P, Jin L, Liu Y, Tang Y, Song Y, Liu J, Hu X, Li CY, Song L, Qin J, Wu F, Lan F, Zhang Y, Xiao RP. | 11/30/2019 |
| Results reveal an indispensable function of CAMK2G in neurodevelopment and indicate that the CAMK2G p.Arg292Pro de novo mutation acts as a pathogenic gain-of-function mutation causing severe intellectual disability. CAMK2G p.Arg292Pro has constitutive activity toward cytosolic targets, rather than impaired targeting to the nucleus. | The intellectual disability-associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain-of-function.
Proietti Onori M, Koopal B, Everman DB, Worthington JD, Jones JR, Ploeg MA, Mientjes E, van Bon BW, Kleefstra T, Schulman H, Kushner SA, Küry S, Elgersma Y, van Woerden GM., Free PMC Article | 10/12/2019 |
| The authors identify active CaMKII as a novel connection between organelle beta-oxidation and acetyl-CoA transport with cell survival, migration, and prostate cancer metastasis | Organelle-Derived Acetyl-CoA Promotes Prostate Cancer Cell Survival, Migration, and Metastasis via Activation of Calmodulin Kinase II.
Yu G, Cheng CJ, Lin SC, Lee YC, Frigo DE, Yu-Lee LY, Gallick GE, Titus MA, Nutt LK, Lin SH., Free PMC Article | 06/15/2019 |
| The data further showed that mitochondrial fission significantly promoted the reprogramming of focal-adhesion dynamics and lamellipodia formation in hepatocellular carcinoma cells mainly by activating typical Ca(2+) /CaMKII/ERK/FAK pathway. | Mitochondrial fission promotes cell migration by Ca(2+) /CaMKII/ERK/FAK pathway in hepatocellular carcinoma.
Sun X, Cao H, Zhan L, Yin C, Wang G, Liang P, Li J, Wang Z, Liu B, Huang Q, Xing J. | 04/13/2019 |
| Subunit exchange enhances information retention by CaMKII in dendritic spines. | Subunit exchange enhances information retention by CaMKII in dendritic spines.
Singh D, Bhalla US., Free PMC Article | 03/16/2019 |
| point mutation R292P sufficient to disrupt gene expression and spatial learning | Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory.
Cohen SM, Suutari B, He X, Wang Y, Sanchez S, Tirko NN, Mandelberg NJ, Mullins C, Zhou G, Wang S, Kats I, Salah A, Tsien RW, Ma H., Free PMC Article | 12/22/2018 |
| The effect of Ca(2+), domain-specificity, and CaMKII on CaM binding to NaV1.1 has been reported. | The Effect of Ca(2+), Lobe-Specificity, and CaMKII on CaM Binding to Na(V)1.1.
Li J, Yu Z, Xu J, Feng R, Gao Q, Boczek T, Liu J, Li Z, Wang Q, Lei M, Gong J, Hu H, Minobe E, Ji HL, Kameyama M, Guo F., Free PMC Article | 12/22/2018 |
| The data suggest T287 autophosphorylation regulates substrate gating, an intrinsic property of the catalytic domain, which is amplified within the multivalent architecture of the calcium/calmodulin-dependent protein kinase II holoenzyme. | Activation State-Dependent Substrate Gating in Ca(2+)/Calmodulin-Dependent Protein Kinase II.
Johnson DE, Hudmon A., Free PMC Article | 09/8/2018 |
| These findings indicate that the CaMKII-mediated GluA1 phosphorylation of S567 and S831 is critical for P2X2-mediated AMPAR internalization and ATP-driven synaptic depression. | P2X-mediated AMPA receptor internalization and synaptic depression is controlled by two CaMKII phosphorylation sites on GluA1 in hippocampal neurons.
Pougnet JT, Compans B, Martinez A, Choquet D, Hosy E, Boué-Grabot E., Free PMC Article | 05/26/2018 |
| Laminin is instructive and CaMKII is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture. | Laminin is instructive and calmodulin dependent kinase II is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture.
Vezina-Audette R, Tremblay M, Carbonetto S. | 01/6/2018 |