| Transcriptional Regulatory Role of NELL2 in Preproenkephalin Gene Expression. | Transcriptional Regulatory Role of NELL2 in Preproenkephalin Gene Expression.
Ha CM, Kim DH, Lee TH, Kim HR, Choi J, Kim Y, Kang D, Park JW, Ojeda SR, Jeong JK, Lee BJ., Free PMC Article | 08/27/2022 |
| NELL2 Function in Axon Development of Hippocampal Neurons. | NELL2 Function in Axon Development of Hippocampal Neurons.
Kim HR, Kim DH, An JY, Kang D, Park JW, Hwang EM, Seo EJ, Jang IH, Ha CM, Lee BJ., Free PMC Article | 02/2/2021 |
| Report shows that neural tissue-enriched multifunctional protein, NELL2 is a regulatory component of feeding behavior, possibly through a modulation of neuronal activity in the hypothalamus. | A Role of Central NELL2 in the Regulation of Feeding Behavior in Rats.
Jeong JK, Kim JG, Kim HR, Lee TH, Park JW, Lee BJ., Free PMC Article | 05/6/2017 |
| Data indicate that RNA interference of NEL-like protein 2 (NELL2) reduced NELL2 and gonadotropin-releasing hormone (GnRH) expression at multiple stages of sexual development. | Effects of NELL2 on the regulation of GnRH expression and puberty in female rats.
Zhou SS, Li P. | 06/27/2015 |
| Results suggest that the N-terminal region of NELL2 determines both the pattern of its intracellular expression and transport and may affect the cellular activity of cells in a paracrine or autocrine manner. | The molecular mechanism of NELL2 movement and secretion in hippocampal progenitor HiB5 cells.
Ha CM, Hwang EM, Kim E, Lee DY, Chang S, Lee BJ, Hong SG, Park JY., Free PMC Article | 07/26/2014 |
| It was shown that Nell2 expression at both mRNA and protein levels is localized to retinal ganglion cells. Nell2 had a molecular weight of ~ 140 kDa and 90 kDa, corresponding to the glycosylated and non-glycosylated form, respectively. | The neuronal EGF-related gene Nell2 interacts with Macf1 and supports survival of retinal ganglion cells after optic nerve injury.
Munemasa Y, Chang CS, Kwong JM, Kyung H, Kitaoka Y, Caprioli J, Piri N., Free PMC Article | 08/25/2012 |
| involved in the maintenance of the normal female reproductive cycle | Regulation of the female rat estrous cycle by a neural cell-specific epidermal growth factor-like repeat domain containing protein, NELL2.
Ryu BJ, Kim HR, Jeong JK, Lee BJ., Free PMC Article | 12/31/2011 |
| These results suggest that NELL2-Tsp,a novel alternative splice variant of rat NELL2, may act as a negative regulator of wild-type NELL2. | Identification and characterization of a truncated isoform of NELL2.
Kim DG, Hwang EM, Yoo JC, Kim E, Park N, Rhee S, Ha CM, Hong SG, Park JY. | 03/22/2010 |
| NELL2 is a new component of glutamatergic neurons and is involved in a major, glutamate-dependent, process of neuroendocrine regulation. | NELL2, a neuron-specific EGF-like protein, is selectively expressed in glutamatergic neurons and contributes to the glutamatergic control of GnRH neurons at puberty.
Ha CM, Choi J, Choi EJ, Costa ME, Lee BJ, Ojeda SR. | 01/21/2010 |
| highest levels of NELL2 were detected in the hippocampus and the cerebellum. In the cerebellar cortex NELL2 was observed only in the GABAergic Purkinje cells not in the excitatory granular cells. | Region- and neuronal phenotype-specific expression of NELL2 in the adult rat brain.
Jeong JK, Kim HR, Hwang SM, Park JW, Lee BJ. | 01/21/2010 |
| Expression of NELL2 in the neonatal brain is important for the estrogen-induced normal development of the sexually dimorphic nucleus of the pre-optic area and the normalcy of sexual behavior in male rats. | NELL2 participates in formation of the sexually dimorphic nucleus of the pre-optic area in rats.
Jeong JK, Ryu BJ, Choi J, Kim DH, Choi EJ, Park JW, Park JJ, Lee BJ. | 01/21/2010 |
| NELL2 may play an important role in the development of the CNS as well as maintenance of neural functions, by regulating the intracellular machinery involving Ca2+ signaling, synaptic transport and/or release of vesicles | Ontogeny and the possible function of a novel epidermal growth factor-like repeat domain-containing protein, NELL2, in the rat brain.
Kim H, Ha CM, Choi J, Choi EJ, Jeon J, Kim C, Park SK, Kang SS, Kim K, Lee BJ. | 01/21/2010 |
| an alternatively spliced variant of the NELL2 gene that yields cytosolic NELL2. Immunoprecipitation analysis revealed that cNELL2 interacts with PKCbeta1. These results suggest that cNELL2 is involved in PKCbeta1-mediated intracellular signaling. | Alternative splicing generates a novel non-secretable cytosolic isoform of NELL2.
Hwang EM, Kim DG, Lee BJ, Choi J, Kim E, Park N, Kang D, Han J, Choi WS, Hong SG, Park JY. | 01/21/2010 |