| The proliferation of atypical hepatocytes and CDT1 expression in noncancerous tissue are associated with the postoperative recurrence of hepatocellular carcinoma. | The proliferation of atypical hepatocytes and CDT1 expression in noncancerous tissue are associated with the postoperative recurrence of hepatocellular carcinoma.
Moriyama M, Kanda T, Midorikawa Y, Matsumura H, Masuzaki R, Nakamura H, Ogawa M, Matsuoka S, Shibata T, Yamazaki M, Kuroda K, Nakayama H, Higaki T, Kanemaru K, Miki T, Sugitani M, Takayama T., Free PMC Article | 12/10/2022 |
| Long non-coding RNA-PCGEM1 contributes to prostate cancer progression by sponging microRNA miR-129-5p to enhance chromatin licensing and DNA replication factor 1 expression. | Long non-coding RNA-PCGEM1 contributes to prostate cancer progression by sponging microRNA miR-129-5p to enhance chromatin licensing and DNA replication factor 1 expression.
Fu Q, Wang F, Yang J, Sun W, Hu Z, Xu L, Chu H, Wang X, Zhang W., Free PMC Article | 04/30/2022 |
| Elevated expression of CDT1 in childhood acute lymphoblastic leukemia promotes cell proliferation, invasion and migration through activation of EMT. | Elevated expression of CDT1 in childhood acute lymphoblastic leukemia promotes cell proliferation, invasion and migration through activation of EMT.
Shi HX, Huang SW, Luo WJ, Pan F, Jin HJ, Wei W. | 09/25/2021 |
| Successful pregnancies in an adult with Meier-Gorlin syndrome harboring biallelic CDT1 variants. | Successful pregnancies in an adult with Meier-Gorlin syndrome harboring biallelic CDT1 variants.
Knapp KM, Murray J, Temple IK, Bicknell LS. | 07/24/2021 |
| SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors. | SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.
Jo U, Murai Y, Chakka S, Chen L, Cheng K, Murai J, Saha LK, Miller Jenkins LM, Pommier Y., Free PMC Article | 06/26/2021 |
| Cdt1 mutations found in humans afflicted with Meier-Gorlin syndrome result in either Cdt1/minichromosome maintenance protein binding or cyclin/CDK binding defects | Cdt1 variants reveal unanticipated aspects of interactions with cyclin/CDK and MCM important for normal genome replication.
Pozo PN, Matson JP, Cole Y, Kedziora KM, Grant GD, Temple B, Cook JG., Free PMC Article | 05/16/2020 |
| Mitotic kinase Aurora B interacts with and phosphorylates Cdt1. Aurora B-phosphomimetic Cdt1 exhibited attenuated MT binding, and its cellular expression induced defective kinetochore-microtubule attachments with a concomitant delay in mitotic progression. | Cdt1 stabilizes kinetochore-microtubule attachments via an Aurora B kinase-dependent mechanism.
Agarwal S, Smith KP, Zhou Y, Suzuki A, McKenney RJ, Varma D., Free PMC Article | 09/28/2019 |
| The deletion of the entire C-terminal region of Cdt2 decreased its polyubiquitination activity towards Cdt1, resulting in decreased Cdt1 degradation. | A DNA-binding domain in the C-terminal region of Cdt2 enhances the DNA synthesis-coupled CRL4Cdt2 ubiquitin ligase activity for Cdt1.
Mazian MA, Suenaga N, Ishii T, Hayashi A, Shiomi Y, Nishitani H. | 08/3/2019 |
| Results show that both Cdc6 and Cdt1, when expressed in a high level, alone or in combination, were significantly associated with poorer survival in the breast cancer patient cohort. In line with this finding, the expression of Cdc6 and Cdt1 was upregulated in breast cancer cells compared to normal breast epithelial cells. Expression of Cdc6 and Cdt1 was significantly higher in ER negative breast cancer. | The prognostic significance of Cdc6 and Cdt1 in breast cancer.
Mahadevappa R, Neves H, Yuen SM, Bai Y, McCrudden CM, Yuen HF, Wen Q, Zhang SD, Kwok HF., Free PMC Article | 09/8/2018 |
| CDT1, MCM7, and NUDT1 were shown to be up-regulated in hepatocellular carcinoma tissues and provide a more accurate diagnosis than alpha-fetal protein alone. | Five Novel Oncogenic Signatures Could Be Utilized as AFP-Related Diagnostic Biomarkers for Hepatocellular Carcinoma Based on Next-Generation Sequencing.
Yu Z, Wang R, Chen F, Wang J, Huang X. | 05/26/2018 |
| PPP2R3B codes for the PR70 protein, a regulatory substrate-recognizing subunit of protein phosphatase 2A. PR70 decreased melanoma growth by negatively interfering with DNA replication and cell cycle progression through its role in stabilizing CDC6-chromatin licensing and CDT1 interaction | The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene.
van Kempen LC, Redpath M, Elchebly M, Klein KO, Papadakis AI, Wilmott JS, Scolyer RA, Edqvist PH, Pontén F, Schadendorf D, van Rijk AF, Michiels S, Dumay A, Helbling-Leclerc A, Dessen P, Wouters J, Stass M, Greenwood CM, Ghanem GE, van den Oord J, Feunteun J, Spatz A. | 12/30/2017 |
| USP37 interacts with Cdt1 and is able to de-ubiquitinate Cdt1 in vivo and, USP37 is able to regulate the loading of MCM complexes onto the chromatin. | USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication.
Hernández-Pérez S, Cabrera E, Amoedo H, Rodríguez-Acebes S, Koundrioukoff S, Debatisse M, Méndez J, Freire R., Free PMC Article | 11/4/2017 |
| mismatch repair (MMR) proteins are also involved in the degradation of Cdt1 after ultraviolet irradiation in the G1 phase | Mismatch repair proteins recruited to ultraviolet light-damaged sites lead to degradation of licensing factor Cdt1 in the G1 phase.
Tanaka M, Takahara M, Nukina K, Hayashi A, Sakai W, Sugasawa K, Shiomi Y, Nishitani H., Free PMC Article | 07/1/2017 |
| Cdt1-binding protein GRWD1 promotes chromatin fluidity by influencing nucleosome structures, e.g., by transient eviction of H2A-H2B, and thereby promotes efficient MCM loading at replication origins. | Nucleosome assembly and disassembly activity of GRWD1, a novel Cdt1-binding protein that promotes pre-replication complex formation.
Aizawa M, Sugimoto N, Watanabe S, Yoshida K, Fujita M. | 07/1/2017 |
| ATM silencing induced partial reduction in levels of Skp2, a component of SCF(Skp2) ubiquitin ligase that controls Cdt1 degradation. | ATM regulates Cdt1 stability during the unperturbed S phase to prevent re-replication.
Iwahori S, Kohmon D, Kobayashi J, Tani Y, Yugawa T, Komatsu K, Kiyono T, Sugimoto N, Fujita M., Free PMC Article | 01/17/2015 |
| FBXO31 interacts with Cdt1 and regulates the degradation of Cdt1 in G2 phase. | SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G2 phase of cell cycle to prevent re-replication.
Johansson P, Jeffery J, Al-Ejeh F, Schulz RB, Callen DF, Kumar R, Khanna KK., Free PMC Article | 10/18/2014 |
| Protein levels of Geminin and Cdt1 are tightly regulated through the cell cycle, and the Cdt1-Geminin complex likely acts as a molecular switch that can enable or disable the firing of each origin of replication. | Cdt1 and geminin in DNA replication initiation.
Caillat C, Perrakis A. | 02/22/2014 |
| These results demonstrate an important role for Cdt1 in human papillomavirus E7-induced rereplication and shed light on mechanisms by which human papillomavirus induces genomic instability. | Human papillomavirus E7 induces rereplication in response to DNA damage.
Fan X, Liu Y, Heilman SA, Chen JJ., Free PMC Article | 03/2/2013 |
| ATR, activated after DNA damage, phosphorylates Cdt2 and promotes the rapid degradation of Cdt1 after UV irradiation in the G1 phase of the cell cycle. | Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.
Sakaguchi H, Takami T, Yasutani Y, Maeda T, Morino M, Ishii T, Shiomi Y, Nishitani H., Free PMC Article | 02/23/2013 |
| A lethal phenotype was seen in four individuals with compound heterozygous CDT1 mutations | Meier-Gorlin syndrome genotype-phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosis.
de Munnik SA, Bicknell LS, Aftimos S, Al-Aama JY, van Bever Y, Bober MB, Clayton-Smith J, Edrees AY, Feingold M, Fryer A, van Hagen JM, Hennekam RC, Jansweijer MC, Johnson D, Kant SG, Opitz JM, Ramadevi AR, Reardon W, Ross A, Sarda P, Schrander-Stumpel CT, Schoots J, Temple IK, Terhal PA, Toutain A, Wise CA, Wright M, Skidmore DL, Samuels ME, Hoefsloot LH, Knoers NV, Brunner HG, Jackson AP, Bongers EM., Free PMC Article | 09/22/2012 |
| results support the conclusion that Cdt1 binding to Hec1 is essential for an extended Ndc80 configuration and stable kinetochore-microtubule attachment | Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment.
Varma D, Chandrasekaran S, Sundin LJ, Reidy KT, Wan X, Chasse DA, Nevis KR, DeLuca JG, Salmon ED, Cook JG., Free PMC Article | 08/18/2012 |
| Genes in the erythroid differentiation and cell cycle regulation pathways influence interindividual variation in RBC indices. Our results provide insights into the molecular basis underlying variation in RBC traits. | Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits.
Ding K, Shameer K, Jouni H, Masys DR, Jarvik GP, Kho AN, Ritchie MD, McCarty CA, Chute CG, Manolio TA, Kullo IJ., Free PMC Article | 07/7/2012 |
| FOXO3 is a binding partner of Cdt1. | Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1.
Zhang Y, Xing Y, Zhang L, Mei Y, Yamamoto K, Mak TW, You H., Free PMC Article | 06/9/2012 |
| The over-expression of geminin and cdt1 may play an important role in pathogenesis of acute leukemia. | Expressions of cell cycle associated factors geminin and cdt1 in patients with acute leukemia.
Zhang KH, Li GL, Liu ZZ. | 01/21/2012 |
| Cdt1- and SNF2H-mediated promotion of MCM loading may be biologically relevant for the regulation of DNA replication. | Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation.
Sugimoto N, Yugawa T, Iizuka M, Kiyono T, Fujita M., Free PMC Article | 12/31/2011 |