| TIP60 is required for tumorigenesis in non-small cell lung cancer. | TIP60 is required for tumorigenesis in non-small cell lung cancer.
Shibahara D, Akanuma N, Kobayashi IS, Heo E, Ando M, Fujii M, Jiang F, Prin PN, Pan G, Wong KK, Costa DB, Bararia D, Tenen DG, Watanabe H, Kobayashi SS., Free PMC Article | 06/7/2023 |
| The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development. | The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development.
Gehlen-Breitbach S, Schmid T, Fröb F, Rodrian G, Weider M, Wegner M, Gölz L., Free PMC Article | 04/12/2023 |
| Tip60/KAT5 Histone Acetyltransferase Is Required for Maintenance and Neurogenesis of Embryonic Neural Stem Cells. | Tip60/KAT5 Histone Acetyltransferase Is Required for Maintenance and Neurogenesis of Embryonic Neural Stem Cells.
Tominaga K, Sakashita E, Kasashima K, Kuroiwa K, Nagao Y, Iwamori N, Endo H., Free PMC Article | 02/15/2023 |
| Depletion of Tip60/Kat5 affects the hepatic antioxidant system in mice. | Depletion of Tip60/Kat5 affects the hepatic antioxidant system in mice.
Kocpinar EF, Baltaci NG, Akkemik E, Budak H. | 01/28/2023 |
| Tip60/Kat5 may be a novel candidate histone acetyltransferase for the regulation of liver iron localization via acetylation. | Tip60/Kat5 may be a novel candidate histone acetyltransferase for the regulation of liver iron localization via acetylation.
Baltacı NG, Toraman E, Akyüz M, Kalın ŞN, Budak H. | 11/26/2022 |
| Conditional depletion of the acetyltransferase Tip60 protects against the damaging effects of myocardial infarction. | Conditional depletion of the acetyltransferase Tip60 protects against the damaging effects of myocardial infarction.
Wang X, Wan TC, Lauth A, Purdy AL, Kulik KR, Patterson M, Lough JW, Auchampach JA., Free PMC Article | 05/14/2022 |
| Tip60 might be a candidate for the acetylation of hepatic carbonic anhydrase I and III in mice. | Tip60 might be a candidate for the acetylation of hepatic carbonic anhydrase I and III in mice.
Gönül Baltacı N, Koçpınar EF, Budak H. | 01/15/2022 |
| Evidence that the acetyltransferase Tip60 induces the DNA damage response and cell-cycle arrest in neonatal cardiomyocytes. | Evidence that the acetyltransferase Tip60 induces the DNA damage response and cell-cycle arrest in neonatal cardiomyocytes.
Wang X, Lupton C, Lauth A, Wan TC, Foster P, Patterson M, Auchampach JA, Lough JW., Free PMC Article | 01/15/2022 |
| O-GlcNAc modified-TIP60/KAT5 is required for PCK1 deficiency-induced HCC metastasis. | O-GlcNAc modified-TIP60/KAT5 is required for PCK1 deficiency-induced HCC metastasis.
Liu R, Gou D, Xiang J, Pan X, Gao Q, Zhou P, Liu Y, Hu J, Wang K, Tang N., Free PMC Article | 01/8/2022 |
| Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance. | Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance.
Numata A, Kwok HS, Zhou QL, Li J, Tirado-Magallanes R, Angarica VE, Hannah R, Park J, Wang CQ, Krishnan V, Rajagopalan D, Zhang Y, Zhou S, Welner RS, Osato M, Jha S, Bohlander SK, Göttgens B, Yang H, Benoukraf T, Lough JW, Bararia D, Tenen DG., Free PMC Article | 06/19/2021 |
| TIP60/KAT5 is required for neuronal viability in hippocampal CA1. | TIP60/KAT5 is required for neuronal viability in hippocampal CA1.
Urban I, Kerimoglu C, Sakib MS, Wang H, Benito E, Thaller C, Zhou X, Yan J, Fischer A, Eichele G., Free PMC Article | 10/31/2020 |
| These results suggest a concept in which an environment of DNA damage repair, which occurs with decreased KAT5, may affect DNA methylation status. | Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes.
Hishikawa A, Hayashi K, Abe T, Kaneko M, Yokoi H, Azegami T, Nakamura M, Yoshimoto N, Kanda T, Sakamaki Y, Itoh H. | 03/14/2020 |
| We show that transcriptional activators control BRD4-PTEFb recruitment to E-box-containing circadian promoters. During the activating phase of the circadian cycle, the lysine acetyltransferase TIP60 acetylates the transcriptional activator BMAL1 leading to recruitment of BRD4 and the pause release factor P-TEFb, followed by productive elongation of circadian transcripts | Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters.
Petkau N, Budak H, Zhou X, Oster H, Eichele G., Free PMC Article | 02/29/2020 |
| These findings show that Tip55 is dispensable for the pre- and early post-implantation roles of Kat5, but is essential during organogenesis. | TIP55, a splice isoform of the KAT5 acetyltransferase, is essential for developmental gene regulation and organogenesis.
Acharya D, Nera B, Milstone ZJ, Bourke L, Yoon Y, Rivera-Pérez JA, Trivedi CM, Fazzio TG., Free PMC Article | 10/26/2019 |
| that phosphorylation of TIP60 on serines 90 and 86 is important for limiting the accumulation of the pro-end joining factor 53BP1 at DNA double-strand breaks in S and G2 cell cycle phases | Phosphorylation of TIP60 Suppresses 53BP1 Localization at DNA Damage Sites.
Li ML, Jiang Q, Bhanu NV, Wu J, Li W, Garcia BA, Greenberg RA., Free PMC Article | 10/26/2019 |
| Nrf1, RUVBL1, and TIP60 proteins were co-recruited to the promoter regions of proteasome genes after proteasome inhibitor treatments. | Nrf1-mediated transcriptional regulation of the proteasome requires a functional TIP60 complex.
Vangala JR, Radhakrishnan SK., Free PMC Article | 06/29/2019 |
| mTORC1 and GSK3-TIP60 signaling converge to modulate autophagosome maturation and lipid metabolism through Pacer. | Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism.
Cheng X, Ma X, Zhu Q, Song D, Ding X, Li L, Jiang X, Wang X, Tian R, Su H, Shen Z, Chen S, Liu T, Gong W, Liu W, Sun Q. | 06/29/2019 |
| Study in mice reports that Marcks is regulated by acetylation through Tip60 and Sirt2. Maternal diabetes-induced MARCKS acetylation is required for its phosphorylation, which disables the protective effects of MARCKS on mitochondria and the endoplasmic reticulum, leading to cellular organelle stress and neural tube defect formation. | Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy.
Yang P, Xu C, Reece EA, Chen X, Zhong J, Zhan M, Stumpo DJ, Blackshear PJ, Yang P., Free PMC Article | 02/23/2019 |
| Fatty acids stimulate Tip60-dependent acetylation and endoplasmic reticulum translocation of phosphatidic acid phosphatase lipin 1 to generate diacylglycerol for triacylglycerols synthesis. | Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate.
Li TY, Song L, Sun Y, Li J, Yi C, Lam SM, Xu D, Zhou L, Li X, Yang Y, Zhang CS, Xie C, Huang X, Shui G, Lin SY, Reue K, Lin SC., Free PMC Article | 02/2/2019 |
| Tip60 controls homologous recombination (HR)-directed DNA repair, and that Tip60 levels correlate inversely with a gene expression signature associated with defective HR-directed DNA repair. | The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair.
Bassi C, Li YT, Khu K, Mateo F, Baniasadi PS, Elia A, Mason J, Stambolic V, Pujana MA, Mak TW, Gorrini C., Free PMC Article | 01/13/2018 |
| Results report that EPC1 and TIP60 are co-expressed in male germ cells. Genetic ablation of either Epc1 or Tip60 disrupts hyperacetylation and impairs histone replacement, in turn causing aberrant spermatid development. | EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice.
Dong Y, Isono KI, Ohbo K, Endo TA, Ohara O, Maekawa M, Toyama Y, Ito C, Toshimori K, Helin K, Ogonuki N, Inoue K, Ogura A, Yamagata K, Kitabayashi I, Koseki H., Free PMC Article | 10/7/2017 |
| these results identify a new compaction pathway of mammalian pericentric heterochromatin relying on Tip60 that might be dependent on BRD2 recruitment by H4K12 acetylation. | Control of genetic stability by a new heterochromatin compaction pathway involving the Tip60 histone acetyltransferase.
Grézy A, Chevillard-Briet M, Trouche D, Escaffit F., Free PMC Article | 09/24/2016 |
| The expression of putative SOX4 target genes during myoblast differentiation is specifically regulated by the molecular switching of the co-activator KAT5 and the co-repressor HDAC1 on SOX4 transcriptional activation. | KAT5-mediated SOX4 acetylation orchestrates chromatin remodeling during myoblast differentiation.
Jang SM, Kim JW, Kim CH, An JH, Johnson A, Song PI, Rhee S, Choi KH., Free PMC Article | 04/16/2016 |
| TIP60 K327 acetylation allows TIP60 to switch binding partners. conditional knockout in Treg cells results in autoimmune disease. | Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60.
Xiao Y, Nagai Y, Deng G, Ohtani T, Zhu Z, Zhou Z, Zhang H, Ji MQ, Lough JW, Samanta A, Hancock WW, Greene MI., Free PMC Article | 08/22/2015 |
| Allele compensation in tip60+/- mice rescues white adipose tissue function in vivo. | Allele compensation in tip60+/- mice rescues white adipose tissue function in vivo.
Gao Y, Hamers N, Rakhshandehroo M, Berger R, Lough J, Kalkhoven E., Free PMC Article | 06/20/2015 |