| Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization in liver cirrhosis and hepatocellular carcinoma rat model via the MK/integrin signaling pathway. | Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization in liver cirrhosis and hepatocellular carcinoma rat model via the MK/integrin signaling pathway.
Fu C, Zhang Y, Xi WJ, Xu K, Meng F, Ma T, Li W, Wu L, Chen Z. | 10/28/2023 |
| MiR-326 targets MDK to regulate the progression of cardiac hypertrophy through blocking JAK/STAT and MAPK signaling pathways. | MiR-326 targets MDK to regulate the progression of cardiac hypertrophy through blocking JAK/STAT and MAPK signaling pathways.
Zhang J, Wei X, Zhang W, Wang F, Li Q. | 11/28/2020 |
| Data suggest that retinoic acid up-regulates Mdk gene expression via Rar signaling in neurons of anterior pituitary which also express Raldh1. (Mdk = midkine; Rar = retinoic acid receptor; Raldh1= retinaldehyde dehydrogenase 1) | Effect of retinoic acid on midkine gene expression in rat anterior pituitary cells.
Maliza R, Fujiwara K, Azuma M, Kikuchi M, Yashiro T. | 06/2/2018 |
| MK and its receptor, protein tyrosine phosphatase receptor-type Z (Ptprz1), are present in the adult rat pituitary | Expression of the heparin-binding growth factor midkine and its receptor, Ptprz1, in adult rat pituitary.
Fujiwara K, Horiguchi K, Maliza R, Tofrizal A, Batchuluun K, Ramadhani D, Syaidah R, Tsukada T, Azuma M, Kikuchi M, Yashiro T. | 11/21/2015 |
| We hypothesize a role for these cytokines in mediating, at least in part, acute neuroprotective effects and chronic neurotrophic adaptations that contribute to drug dependence. | Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration.
García-Pérez D, Luisa Laorden M, Núñez C, Victoria Milanés M. | 11/22/2014 |
| Downregulation of MK gene on D15 may contribute to primary PH in the nitrofen CDH model by disrupting early lung morphogenesis. | Downregulation of Midkine gene expression and its response to retinoic acid treatment in the nitrofen-induced hypoplastic lung.
Doi T, Shintaku M, Dingemann J, Ruttenstock E, Puri P. | 05/28/2011 |
| The apoA-V-midkine binding at the cell surface using antibody directed against midkine is able to influence INS-1 cell function as insulin secretion. | Apolipoprotein A-V modulates insulin secretion in pancreatic beta-cells through its interaction with midkine.
Helleboid-Chapman A, Nowak M, Helleboid S, Moitrot E, Rommens C, Dehondt H, Héliot L, Drobecq H, Fruchart-Najib J, Fruchart JC. | 02/22/2010 |
| The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells. | The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells.
Zhang H, Garber SJ, Cui Z, Foley JP, Mohan GS, Jobanputra M, Kaplan F, Sweezey NB, Gonzales LW, Savani RC., Free PMC Article | 01/21/2010 |
| upregulation of PTN, but not MK, could play an important role in the recovery from nerve damage | Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain.
Ezquerra L, Alguacil LF, Nguyen T, Deuel TF, Silos-Santiago I, Herradon G. | 01/21/2010 |
| midkine is synthesized, released, and taken up in anterior horn motor neurons in an autocrine fashion with lipoprotein receptor-related protein | Midkine expression in rat spinal motor neurons following sciatic nerve injury.
Sakakima H, Yoshida Y, Kadomatsu K, Yuzawa Y, Matsuo S, Muramatsu T. | 01/21/2010 |
| Morphine and yohimbine regulate Mdk expression in the hippocampus. | Morphine and yohimbine regulate midkine gene expression in the rat hippocampus.
Ezquerra L, Pérez-García C, Garrido E, Díez-Fernández C, Deuel TF, Alguacil LF, Herradón G. | 01/21/2010 |
| alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine | alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor.
Muramatsu H, Zou P, Suzuki H, Oda Y, Chen GY, Sakaguchi N, Sakuma S, Maeda N, Noda M, Takada Y, Muramatsu T. | 01/21/2010 |
| midkine may have a role for differentiation during skeletal muscle regeneration and may be taken up in an autocrine fashion with -density lipoprotein receptor-related protein | Midkine and its receptor in regenerating rat skeletal muscle after bupivacaine injection.
Sakakima H, Kamizono T, Matsuda F, Izumo K, Ijiri K, Yoshida Y. | 01/21/2010 |
| Midkine (MK) expression does not increase during the repair period of the neuroepithelium (NE). Expression is likely to be suppressed at S-phase and is necessary to maintain the M-phase of NE cells. | Distinctive expression of midkine in the repair period of rat brain during neurogenesis: immunohistochemical and immunoelectron microscopic observations.
Kikuchi-Horie K, Kawakami E, Kamata M, Wada M, Hu JG, Nakagawa H, Ohara K, Watabe K, Oyanagi K. | 01/21/2010 |
| The expression of midkine in rat colonic tissues during the healing of dextran sodium sulfate-induced colitis is reported. | Increased expression of midkine in the rat colon during healing of experimental colitis.
Yuki T, Ishihara S, Rumi MA, Ortega-Cava CF, Kadowaki Y, Kazumori H, Ishimura N, Amano Y, Moriyama N, Kinoshita Y. | 01/21/2010 |
| Midkine, pleiotrophin (PTN), and their receptors syndecan-3 and receptor protein tyrosine phosphatase beta/zeta, were highly expressed in the striatum during developmen | Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease.
Marchionini DM, Lehrmann E, Chu Y, He B, Sortwell CE, Becker KG, Freed WJ, Kordower JH, Collier TJ. | 01/21/2010 |