| Camk2a suppresses denervated muscle atrophy by maintaining the Ca2+ homeostasis in muscle cells. | Camk2a suppresses denervated muscle atrophy by maintaining the Ca2+ homeostasis in muscle cells.
Zhang Y, Xia M, Zhao T, Zhang Q, Li R, Yang L. | 12/1/2023 |
| Association of CaMK2A and MeCP2 signaling pathways with cognitive ability in adolescents. | Association of CaMK2A and MeCP2 signaling pathways with cognitive ability in adolescents.
Lee LC, Su MT, Huang HY, Cho YC, Yeh TK, Chang CY., Free PMC Article | 04/9/2022 |
| Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis. | Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis.
Nalesso G, Thorup AS, Eldridge SE, De Palma A, Kaur A, Peddireddi K, Blighe K, Rana S, Stott B, Vincent TL, Thomas BL, Bertrand J, Sherwood J, Fioravanti A, Pitzalis C, Dell'Accio F., Free PMC Article | 12/11/2021 |
| [Dysregulation of MAD2L1/CAMK2A/PTTG1 Gene Cluster Maintains the Stemness Characteristics of Uterine Corpus Endometrial Carcinoma]. | [Dysregulation of MAD2L1/CAMK2A/PTTG1 Gene Cluster Maintains the Stemness Characteristics of Uterine Corpus Endometrial Carcinoma].
Zheng J, Zhang YW, Pan ZF. | 11/22/2021 |
| Association of a CAMK2A genetic variant with logical memory performance and hippocampal volume in the elderly. | Association of a CAMK2A genetic variant with logical memory performance and hippocampal volume in the elderly.
Rhein C, Mühle C, Lenz B, Richter-Schmidinger T, Kogias G, Boix F, Lourdusamy A, Dörfler A, Peters O, Ramirez A, Jessen F, Maier W, Hüll M, Frölich L, Teipel S, Wiltfang J, Kornhuber J, Müller CP. | 10/2/2021 |
| Nanoscale regulation of L-type calcium channels differentiates between ischemic and dilated cardiomyopathies. | Nanoscale regulation of L-type calcium channels differentiates between ischemic and dilated cardiomyopathies.
Sanchez-Alonso JL, Loucks A, Schobesberger S, van Cromvoirt AM, Poulet C, Chowdhury RA, Trayanova N, Gorelik J., Free PMC Article | 05/29/2021 |
| Role of Oxidation-Dependent CaMKII Activation in the Genesis of Abnormal Action Potentials in Atrial Cardiomyocytes: A Simulation Study. | Role of Oxidation-Dependent CaMKII Activation in the Genesis of Abnormal Action Potentials in Atrial Cardiomyocytes: A Simulation Study.
Zhao N, Li Q, Sui H, Zhang H., Free PMC Article | 04/17/2021 |
| Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation. | Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.
Bhattacharyya M, Lee YK, Muratcioglu S, Qiu B, Nyayapati P, Schulman H, Groves JT, Kuriyan J., Free PMC Article | 04/3/2021 |
| CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation. | CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation.
Wang SQ, Liu J, Qin J, Zhu Y, Tin VP, Yam JWP, Wong MP, Xiao ZJ., Free PMC Article | 03/20/2021 |
| CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability. | CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability.
Zybura AS, Baucum AJ 2nd, Rush AM, Cummins TR, Hudmon A., Free PMC Article | 01/23/2021 |
| Regular aerobic exercise alleviated protein carbonylation modification of CAMKIIalpha and regulated the CAMK signaling pathway, thereby affecting and regulating the homeostasis of apoptosis and autophagy in the striatum to alleviate the neurodegenerative process of Parkinson disease lesion | Regular Aerobic Exercise-Alleviated Dysregulation of CAMKIIα Carbonylation to Mitigate Parkinsonism via Homeostasis of Apoptosis With Autophagy.
Liu W, Fu R, Wang Z, Liu S, Tang C, Li L, Yin D. | 07/25/2020 |
| CaMK2alpha acts as a key antiapoptosis regulator in metabolic stress-resistant CSCs by activating NFkappaB. | Survival of Cancer Stem-Like Cells Under Metabolic Stress via CaMK2α-mediated Upregulation of Sarco/Endoplasmic Reticulum Calcium ATPase Expression.
Park KC, Kim SW, Jeon JY, Jo AR, Choi HJ, Kim J, Lee HG, Kim Y, Mills GB, Noh SH, Lee MG, Park ES, Cheong JH. | 09/28/2019 |
| Together, these data demonstrate that a recessive germline mutation in CAMK2A leads to neurodevelopmental defects in humans and suggest that dysfunctional CAMK2 paralogs may contribute to other neurological disorders. | A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability.
Chia PH, Zhong FL, Niwa S, Bonnard C, Utami KH, Zeng R, Lee H, Eskin A, Nelson SF, Xie WH, Al-Tawalbeh S, El-Khateeb M, Shboul M, Pouladi MA, Al-Raqad M, Reversade B., Free PMC Article | 05/4/2019 |
| We correlated the self-reported time interval between occasional and regular heroin use with the frequency of 12 single nucleotide polymorphisms located within the genomic region of the CamK2A gene. Single marker association analysis (rs10066581, P=0.007), as well as haplotype analysis (global P=0.005), suggested an association with the quantitative trait 'time interval from occasional to regular heroin use. | Association of CamK2A genetic variants with transition time from occasional to regular heroin use in a sample of heroin-dependent individuals.
Eirich A, Biermann T, Müller CP, Kornhuber J, Benyamin B, Hulse GK, Wildenauer DB, Schwab SG. | 02/16/2019 |
| SK current is increased via the enhanced activation of CaMKII in patients with atrial fibrillation. | Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) Increases Small-Conductance Ca2+-Activated K+ Current in Patients with Chronic Atrial Fibrillation.
Fan X, Yu Y, Lan H, Ou X, Yang L, Li T, Cao J, Zeng X, Li M., Free PMC Article | 09/29/2018 |
| Study first demonstrated that CaMKII-alpha was over-expressed in human colon cancers and was associated with cancer differentiation. | Ca(2+)/calmodulin-dependent protein kinase II regulates colon cancer proliferation and migration via ERK1/2 and p38 pathways.
Chen W, An P, Quan XJ, Zhang J, Zhou ZY, Zou LP, Luo HS., Free PMC Article | 06/2/2018 |
| The dynamics of calmodulin interactions with neurogranin and Ca(2+) /CAMKII alpha proteins has been reported. | Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca(2+) /calmodulin-dependent kinase II.
Seeger C, Talibov VO, Danielson UH., Free PMC Article | 04/7/2018 |
| oxidative stress activates the TRPM2-Ca(2+)-CAMK2 cascade to phosphorylate BECN1 resulting in autophagy inhibition | Mechanistic study of TRPM2-Ca(2+)-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition.
Wang Q, Guo W, Hao B, Shi X, Lu Y, Wong CW, Ma VW, Yip TT, Au JS, Hao Q, Cheung KH, Wu W, Li GR, Yue J., Free PMC Article | 01/6/2018 |
| two peptides (SIAPNV(-COOH) and SIVMNV(-COOH)) were identified to have considerably improved affinity with K d increase by ~tenfold relative to wild type peptide. Thus, the two peptides are considered as promising lead entities to develop therapeutic molecular agents with high efficacy and specificity to target CaMKIIalpha-MUPP1 interaction. | Structure-based identification of CaMKIIα-interacting MUPP1 PDZ domains and rational design of peptide ligands to target such interaction in human fertilization.
Zhang YL, Han ZF, Sun YP. | 12/9/2017 |
| The importance of CAMK2A and CAMK2B and their auto-phosphorylation in human brain function. | De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.
Küry S, van Woerden GM, Besnard T, Proietti Onori M, Latypova X, Towne MC, Cho MT, Prescott TE, Ploeg MA, Sanders S, Stessman HAF, Pujol A, Distel B, Robak LA, Bernstein JA, Denommé-Pichon AS, Lesca G, Sellars EA, Berg J, Carré W, Busk ØL, van Bon BWM, Waugh JL, Deardorff M, Hoganson GE, Bosanko KB, Johnson DS, Dabir T, Holla ØL, Sarkar A, Tveten K, de Bellescize J, Braathen GJ, Terhal PA, Grange DK, van Haeringen A, Lam C, Mirzaa G, Burton J, Bhoj EJ, Douglas J, Santani AB, Nesbitt AI, Helbig KL, Andrews MV, Begtrup A, Tang S, van Gassen KLI, Juusola J, Foss K, Enns GM, Moog U, Hinderhofer K, Paramasivam N, Lincoln S, Kusako BH, Lindenbaum P, Charpentier E, Nowak CB, Cherot E, Simonet T, Ruivenkamp CAL, Hahn S, Brownstein CA, Xia F, Schmitt S, Deb W, Bonneau D, Nizon M, Quinquis D, Chelly J, Rudolf G, Sanlaville D, Parent P, Gilbert-Dussardier B, Toutain A, Sutton VR, Thies J, Peart-Vissers LELM, Boisseau P, Vincent M, Grabrucker AM, Dubourg C, Undiagnosed Diseases Network, Tan WH, Verbeek NE, Granzow M, Santen GWE, Shendure J, Isidor B, Pasquier L, Redon R, Yang Y, State MW, Kleefstra T, Cogné B, GEM HUGO, Deciphering Developmental Disorders Study, Petrovski S, Retterer K, Eichler EE, Rosenfeld JA, Agrawal PB, Bézieau S, Odent S, Elgersma Y, Mercier S., Free PMC Article | 11/18/2017 |
| This study demonstrate that this ASD-linked de novo CAMK2A mutation disrupts multiple CaMKII functions, induces synaptic deficits, and causes ASD-related behavioral alterations. | A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.
Stephenson JR, Wang X, Perfitt TL, Parrish WP, Shonesy BC, Marks CR, Mortlock DP, Nakagawa T, Sutcliffe JS, Colbran RJ., Free PMC Article | 08/19/2017 |
| CaMKII-mediated recruitment and upregulation of CYLD is expected to remove K63-linked polyubiquitins and facilitate proteasomal degradation at the postsynaptic density. | CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density.
Thein S, Tao-Cheng JH, Li Y, Bayer KU, Reese TS, Dosemeci A., Free PMC Article | 04/2/2016 |
| CAMK2A SNPs were associated with Alzheimer disease and mild cognitive impairment. AG genotype at the CAMK2A-rs3822606 was associated with AD risk. | Reelin signaling pathway genotypes and Alzheimer disease in a Spanish population.
Bufill E, Roura-Poch P, Sala-Matavera I, Antón S, Lleó A, Sánchez-Saudinós B, Tomàs-Abadal L, Puig T, Abós J, Bernades S, Clarimon J, Blesa R. | 02/13/2016 |
| CaMKII phosphorylates SCN5A in vitro on 23 novel serine sites as was identified by mass spectrometry; reduced S516 phosphorylation has been found in human heart failure. | CaMKII Phosphorylation of Na(V)1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure.
Herren AW, Weber DM, Rigor RR, Margulies KB, Phinney BS, Bers DM., Free PMC Article | 02/6/2016 |
| Ca2+/calmodulin-dependent protein kinase-II (CaMKII) has a key role in the plasticity of glutamatergic synapses of the brain. | αCaMKII controls the establishment of cocaine's reinforcing effects in mice and humans.
Easton AC, Lourdusamy A, Havranek M, Mizuno K, Solati J, Golub Y, Clarke TK, Vallada H, Laranjeira R, Desrivières S, Moll GH, Mössner R, Kornhuber J, Schumann G, Giese KP, Fernandes C, Quednow BB, Müller CP., Free PMC Article | 11/7/2015 |