| CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses. | CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses.
Scherlinger M, Li H, Pan W, Li W, Karino K, Vichos T, Boulougoura A, Yoshida N, Tsokos MG, Tsokos GC., Free PMC Article | 02/7/2024 |
| CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation. | CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation.
Zhang Y, Daniel EA, Metcalf J, Dai Y, Reif GA, Wallace DP., Free PMC Article | 01/14/2023 |
| Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis. | Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis.
Bhargava R, Lehoux S, Maeda K, Tsokos MG, Krishfield S, Ellezian L, Pollak M, Stillman IE, Cummings RD, Tsokos GC., Free PMC Article | 02/19/2022 |
| CaMK4 promotes abortion-related Th17 cell imbalance by activating AKT/mTOR signaling pathway. | CaMK4 promotes abortion-related Th17 cell imbalance by activating AKT/mTOR signaling pathway.
Chang S, Yin T, He F, Ding J, Shang Y, Yang J. | 11/6/2021 |
| CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis. | CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.
Sabbir MG., Free PMC Article | 08/14/2021 |
| MiR-507 inhibits the growth and invasion of trophoblasts by targeting CAMK4. | MiR-507 inhibits the growth and invasion of trophoblasts by targeting CAMK4.
Li HQ, Fan JJ, Li XH, Bao D. | 04/24/2021 |
| Comparative transcriptome analysis reveals a potential role for CaMK4 in gammadeltaT17 cells from systemic lupus erythematosus patients with lupus nephritis. | Comparative transcriptome analysis reveals a potential role for CaMK4 in γδT17 cells from systemic lupus erythematosus patients with lupus nephritis.
Du B, Fan X, Lei F, Zhang S, Li G, Xi X. | 11/28/2020 |
| MiR-129-5p inhibits liver cancer growth by targeting calcium calmodulin-dependent protein kinase IV (CAMK4). | MiR-129-5p inhibits liver cancer growth by targeting calcium calmodulin-dependent protein kinase IV (CAMK4).
Li Z, Lu J, Zeng G, Pang J, Zheng X, Feng J, Zhang J., Free PMC Article | 09/12/2020 |
| rs2300782 of gene CAMK4 is associated with diabetic retinopathy incidence and severity among Chinese Hui population. | Associations of rs2300782 CAMK4, rs2292239 ERBB3 and rs10491034 ARHGAP22 with Diabetic Retinopathy Among Chinese Hui Population.
Han M, Dong Z, Duan H, Sun X, Zhang T, Ying M. | 03/21/2020 |
| CaMK4 could be responsible for glycolysis, which contributes to the production of IL-17, and CaMK4 may contribute to aberrant expression of GLUT1 in T cells from patients with active SLE. | Promotion of Calcium/Calmodulin-Dependent Protein Kinase 4 by GLUT1-Dependent Glycolysis in Systemic Lupus Erythematosus.
Koga T, Sato T, Furukawa K, Morimoto S, Endo Y, Umeda M, Sumiyoshi R, Fukui S, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Origuchi T, Nakamura H, Kawakami A. | 01/4/2020 |
| Clinical disease severity directly correlates with calmodulin-dependent kinase IV (CaMKIV) activation, as does expression of proinflammatory cytokines and histologic features of colitis. In wild-type mice, CaMKIV activation is associated with increases in expression of 2 cell cycle proarrest signals: p53 and p21 | Calcium/calmodulin-dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation.
Cunningham KE, Novak EA, Vincent G, Siow VS, Griffith BD, Ranganathan S, Rosengart MR, Piganelli JD, Mollen KP., Free PMC Article | 09/21/2019 |
| CaMK4 is pivotal in immune and nonimmune podocyte injury and that its targeted cell-specific inhibition preserves podocyte structure and function and should have therapeutic value in lupus nephritis and podocytopathies, including focal segmental glomerulosclerosis. | CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.
Maeda K, Otomo K, Yoshida N, Abu-Asab MS, Ichinose K, Nishino T, Kono M, Ferretti A, Bhargava R, Maruyama S, Bickerton S, Fahmy TM, Tsokos MG, Tsokos GC., Free PMC Article | 09/14/2019 |
| vanillin binds strongly to the active site cavity of CAMKIV and stabilized by a large number of non-covalent interactions. | Evidence of vanillin binding to CAMKIV explains the anti-cancer mechanism in human hepatic carcinoma and neuroblastoma cells.
Naz H, Tarique M, Khan P, Luqman S, Ahamad S, Islam A, Ahmad F, Hassan MI. | 07/14/2018 |
| Genotype and allele frequencies of CAMKIV gene SNPs differed significantly between alcohol dependence patients and control subjects. The results of the present study suggest that CAMKIV might be a candidate alcohol dependence gene. | Calcium/calmodulin-dependent protein kinase IV gene polymorphisms in Korean alcohol-dependent patients.
Jung WY, Kim SG, Kim JH, Lee JS. | 06/16/2018 |
| hTau accumulation impairs synapse and memory by CaN-mediated suppression of nuclear CaMKIV/CREB signaling. | Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling.
Yin Y, Gao D, Wang Y, Wang ZH, Wang X, Ye J, Wu D, Fang L, Pi G, Yang Y, Wang XC, Lu C, Ye K, Wang JZ., Free PMC Article | 12/16/2017 |
| Within the pH range 5.0-11.5, CAMK4 maintained both its secondary and tertiary structures, along with its function, whereas significant aggregation was observed at acidic pH (2.0-4.5). | Effect of pH on the structure, function, and stability of human calcium/calmodulin-dependent protein kinase IV: combined spectroscopic and MD simulation studies.
Naz H, Shahbaaz M, Bisetty K, Islam A, Ahmad F, Hassan MI. | 06/24/2017 |
| A positive association was not observed between rs10491334 in the CAMK4 gene and longevity in a Chinese population. | Lack of association between rs10491334 in the CAMK4 gene and longevity in a Chinese population.
Lin R, Zhang Y, Yan D, Liao X, Fu Y, Cai W. | 04/1/2017 |
| The T-allele of rs10491334 in CAMK4 was associated with hypertension in the Uygur group. | CAMK4 gene variation is associated with hypertension in a Uygur population.
Chen SZ, Wang Z, Zhang LN, Lu GL, Zhou CM, Wang DW, Tang ZM, Wang L, Qin L, Zhai ZH. | 11/19/2016 |
| Expression of CaMKIV inhibits autophosphorylation and activation of CaMKII, and elicits G0/G1cell cycle arrest,impairing cell proliferation. | A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells.
Monaco S, Rusciano MR, Maione AS, Soprano M, Gomathinayagam R, Todd LR, Campiglia P, Salzano S, Pastore L, Leggiero E, Wilkerson DC, Rocco M, Selleri C, Iaccarino G, Sankar U, Illario M. | 08/29/2015 |
| An imbalance of specific isoforms of CYFIP1, an FMRP interaction partner, and CAMK4, a transcriptional regulator of the FMRP gene, modulates risk for autism spectrum disorders. | Common variants in genes of the postsynaptic FMRP signalling pathway are risk factors for autism spectrum disorders.
Waltes R, Duketis E, Knapp M, Anney RJ, Huguet G, Schlitt S, Jarczok TA, Sachse M, Kämpfer LM, Kleinböck T, Poustka F, Bölte S, Schmötzer G, Voran A, Huy E, Meyer J, Bourgeron T, Klauck SM, Freitag CM, Chiocchetti AG. | 06/28/2014 |
| CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance. | CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance.
Koga T, Hedrich CM, Mizui M, Yoshida N, Otomo K, Lieberman LA, Rauen T, Crispín JC, Tsokos GC., Free PMC Article | 06/21/2014 |
| CaMK4 regulates beta-cell proliferation and apoptosis in a CREB-dependent manner and CaMK4-induced IRS-2 expression is important in these processes | The CaMK4/CREB/IRS-2 cascade stimulates proliferation and inhibits apoptosis of β-cells.
Liu B, Barbosa-Sampaio H, Jones PM, Persaud SJ, Muller DS., Free PMC Article | 05/11/2013 |
| study suggests that the mutations in CAMK4 may lead to abnormal semen parameters | Novel mutations in calcium/calmodulin-dependent protein kinase IV (CAMK4) gene in infertile men.
Khattri A, Reddy VP, Pandey RK, Sudhakar DVS, Gupta NJ, Chakravarty BN, Deenadayal M, Singh L, Thangaraj K. | 04/27/2013 |
| Phosphorylated Notch1-IC by CaMKIV increases Notch1-IC stability, which enhances osteoclast differentiation. | Calcium/calmodulin-dependent protein kinase IV (CaMKIV) enhances osteoclast differentiation via the up-regulation of Notch1 protein stability.
Choi YH, Ann EJ, Yoon JH, Mo JS, Kim MY, Park HS. | 03/9/2013 |
| Prolongevity genes are activated by CAMKIV, the levels of which are influenced by rs10491334, a single-nucleotide polymorphism associated with human longevity. | Association study on long-living individuals from Southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins.
Malovini A, Illario M, Iaccarino G, Villa F, Ferrario A, Roncarati R, Anselmi CV, Novelli V, Cipolletta E, Leggiero E, Orro A, Rusciano MR, Milanesi L, Maione AS, Condorelli G, Bellazzi R, Puca AA. | 12/10/2011 |