| Functional expression of the proton sensors ASIC1a, TMEM206, and OGR1 together with BKCa channels is associated with cell volume changes and cell death under strongly acidic conditions in DAOY medulloblastoma cells. | Functional expression of the proton sensors ASIC1a, TMEM206, and OGR1 together with BK(Ca) channels is associated with cell volume changes and cell death under strongly acidic conditions in DAOY medulloblastoma cells.
Pissas KP, Gründer S, Tian Y., Free PMC Article | 09/23/2024 |
| A novel mutation in GPR68 causes hypomaturation amelogenesis imperfecta. | A novel mutation in GPR68 causes hypomaturation amelogenesis imperfecta.
Yu S, Liu D, Yan C, Yuan C, Zhang C, Zheng S. | 06/12/2024 |
| pH-sensing G protein-coupled orphan receptor GPR68 is expressed in human cartilage and correlates with degradation of extracellular matrix during OA progression. | pH-sensing G protein-coupled orphan receptor GPR68 is expressed in human cartilage and correlates with degradation of extracellular matrix during OA progression.
Khan NM, Diaz-Hernandez ME, Martin WN, Patel B, Chihab S, Drissi H., Free PMC Article | 12/18/2023 |
| Expression of GPR-68 in Human Corneal and Conjunctival Epithelium. Possible indicator and mediator of attrition associated inflammation at the ocular surface. | Expression of GPR-68 in Human Corneal and Conjunctival Epithelium. Possible indicator and mediator of attrition associated inflammation at the ocular surface.
van Setten GB. | 01/21/2023 |
| GPR-68 in human lacrimal gland. Detection and possible role in the pathogenesis of dry eye disease. | GPR-68 in human lacrimal gland. Detection and possible role in the pathogenesis of dry eye disease.
van Setten GB. | 10/15/2022 |
| pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and Fibrosis. | pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and Fibrosis.
de Vallière C, Cosin-Roger J, Baebler K, Schoepflin A, Mamie C, Mollet M, Schuler C, Bengs S, Lang S, Scharl M, Seuwen K, Ruiz PA, Hausmann M, Rogler G., Free PMC Article | 04/16/2022 |
| The evolution and mechanism of GPCR proton sensing. | The evolution and mechanism of GPCR proton sensing.
Rowe JB, Kapolka NJ, Taghon GJ, Morgan WM, Isom DG., Free PMC Article | 08/28/2021 |
| GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia. | GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia.
Wang T, Zhou G, He M, Xu Y, Rusyniak WG, Xu Y, Ji Y, Simon RP, Xiong ZG, Zha XM., Free PMC Article | 02/20/2021 |
| Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors. | Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors.
Klatt W, Wallner S, Brochhausen C, Stolwijk JA, Schreml S., Free PMC Article | 01/23/2021 |
| CRISPR-addressable yeast strains with applications in human G protein-coupled receptor profiling and synthetic biology. | CRISPR-addressable yeast strains with applications in human G protein-coupled receptor profiling and synthetic biology.
Rowe JB, Taghon GJ, Kapolka NJ, Morgan WM, Isom DG., Free PMC Article | 01/2/2021 |
| A missense mutation of Leu74Pro of OGR1 found in familial amelogenesis imperfecta actually causes the loss of the pH-sensing mechanism. | A missense mutation of Leu74Pro of OGR1 found in familial amelogenesis imperfecta actually causes the loss of the pH-sensing mechanism.
Sato K, Mogi C, Mighell AJ, Okajima F. | 11/28/2020 |
| Ovarian cancer G protein coupled receptor 1 (OGR1) (aka GPR68) acts as coincidence detector of membrane stretch and its physiological ligand, extracellular H(+). OGR1 only responds to extracellular acidification under conditions of membrane stretch and vice versa. | Coincidence Detection of Membrane Stretch and Extracellular pH by the Proton-Sensing Receptor OGR1 (GPR68).
Wei WC, Bianchi F, Wang YK, Tang MJ, Ye H, Glitsch MD. | 10/26/2019 |
| OGR1 expression was correlated with increased expression levels of pro-fibrotic genes and collagen deposition. | Intestinal Activation of pH-Sensing Receptor OGR1 [GPR68] Contributes to Fibrogenesis.
Hutter S, van Haaften WT, Hünerwadel A, Baebler K, Herfarth N, Raselli T, Mamie C, Misselwitz B, Rogler G, Weder B, Dijkstra G, Meier CF, de Vallière C, Weber A, Imenez Silva PH, Wagner CA, Frey-Wagner I, Ruiz PA, Hausmann M. | 03/16/2019 |
| GPR68 is an essential flow sensor in arteriolar endothelium and is a critical signaling component in cardiovascular pathophysiology | GPR68 Senses Flow and Is Essential for Vascular Physiology.
Xu J, Mathur J, Vessières E, Hammack S, Nonomura K, Favre J, Grimaud L, Petrus M, Francisco A, Li J, Lee V, Xiang FL, Mainquist JK, Cahalan SM, Orth AP, Walker JR, Ma S, Lukacs V, Bordone L, Bandell M, Laffitte B, Xu Y, Chien S, Henrion D, Patapoutian A., Free PMC Article | 02/16/2019 |
| High GPR68 expression is associated with pancreatic ductal adenocarcinoma. | GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells.
Wiley SZ, Sriram K, Liang W, Chang SE, French R, McCann T, Sicklick J, Nishihara H, Lowy AM, Insel PA., Free PMC Article | 11/17/2018 |
| different benzodiazepines exhibit a range of biases for OGR1, with sulazepam selectively activating the canonical Gs of the G protein signaling pathway, in heterologous expression systems, as well as in several primary cell types. | Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.
Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, Roth BL, Panettieri RA Jr, Benovic JL, An SS, Dulin NO, Penn RB., Free PMC Article | 10/27/2018 |
| Our results suggest that OGR1-dependent increases in TRPC4 expression may favour formation of highly Ca(2+) -permeable TRPC4-containing channels that promote transformed granule cell migration. Increased motility of cancer cells is a prerequisite for cancer invasion and metastasis, and our findings may point towards a key role for TRPC4 in progression of certain types of medullablastoma. | Functional expression of calcium-permeable canonical transient receptor potential 4-containing channels promotes migration of medulloblastoma cells.
Wei WC, Huang WC, Lin YP, Becker EBE, Ansorge O, Flockerzi V, Conti D, Cenacchi G, Glitsch MD., Free PMC Article | 05/12/2018 |
| Blocking of GPR68 or NF-small ka, CyrillicB activity severely attenuated acidification induced IL-8 production. | Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells.
Chandra V, Karamitri A, Richards P, Cormier F, Ramond C, Jockers R, Armanet M, Albagli-Curiel O, Scharfmann R., Free PMC Article | 03/31/2018 |
| These results suggest that zOGR1, but not GPR4, is also a metal-sensing G-protein-coupled receptor in addition to a proton-sensing G-protein-coupled receptor, although not all metals that activate hOGR1 activated zOGR1. | Manganese and cobalt activate zebrafish ovarian cancer G-protein-coupled receptor 1 but not GPR4.
Negishi J, Omori Y, Shindo M, Takanashi H, Musha S, Nagayama S, Hirayama J, Nishina H, Nakakura T, Mogi C, Sato K, Okajima F, Mochimaru Y, Tomura H. | 03/10/2018 |
| data identify a role for GPR68 as a proton sensor that is required for proper enamel formation | Mutations in the pH-Sensing G-protein-Coupled Receptor GPR68 Cause Amelogenesis Imperfecta.
Parry DA, Smith CE, El-Sayed W, Poulter JA, Shore RC, Logan CV, Mogi C, Sato K, Okajima F, Harada A, Zhang H, Koruyucu M, Seymen F, Hu JC, Simmer JP, Ahmed M, Jafri H, Johnson CA, Inglehearn CF, Mighell AJ., Free PMC Article | 05/27/2017 |
| coexpression of OGR1- and G2A-enhanced proton sensitivity and proton-induced calcium signals. This alteration is attributed to oligomerization of OGR1 and G2A. The oligomeric potential locates receptors at a specific site, which leads to enhanced | Heteromerization of G2A and OGR1 enhances proton sensitivity and proton-induced calcium signals.
Huang YH, Su YS, Chang CJ, Sun WH. | 04/8/2017 |
| Proton-sensing GPCR-YAP Signalling Promotes Cancer-associated Fibroblast Activation of Mesenchymal Stem Cells | Proton-sensing GPCR-YAP Signalling Promotes Cancer-associated Fibroblast Activation of Mesenchymal Stem Cells.
Zhu H, Guo S, Zhang Y, Yin J, Yin W, Tao S, Wang Y, Zhang C., Free PMC Article | 12/24/2016 |
| The deconstruction of OGR1-dependent signaling may aid our understanding of mucosal inflammation mechanisms | The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment.
de Vallière C, Vidal S, Clay I, Jurisic G, Tcymbarevich I, Lang S, Ludwig MG, Okoniewski M, Eloranta JJ, Kullak-Ublick GA, Wagner CA, Rogler G, Seuwen K. | 12/12/2015 |
| Provide evidence for the roles of OGR1 and ASIC1a in the regulation of intestinal passive Mg(2+) absorption. | The roles of acid-sensing ion channel 1a and ovarian cancer G protein-coupled receptor 1 on passive Mg2+ transport across intestinal epithelium-like Caco-2 monolayers.
Thongon N, Ketkeaw P, Nuekchob C., Free PMC Article | 10/25/2014 |
| the expression of OGR1 in myeloid-derived cells, especially in double positive cells, was required for prostate tumor cell-induced immunosuppression. | Role of OGR1 in myeloid-derived cells in prostate cancer.
Yan L, Singh LS, Zhang L, Xu Y. | 03/15/2014 |