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    CLPTM1L CLPTM1 like [ Homo sapiens (human) ]

    Gene ID: 81037, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Exploring the Relationship between CLPTM1L-MS2 Variants and Susceptibility to Bladder Cancer.

    Exploring the Relationship between CLPTM1L-MS2 Variants and Susceptibility to Bladder Cancer.
    Jeong MS, Mun JY, Yang GE, Kim MH, Lee SY, Choi YH, Kim HS, Nam JK, Kim TN, Leem SH., Free PMC Article

    01/31/2024
    CLPTM1L is a GPI-anchoring pathway component targeted by HCMV.

    CLPTM1L is a GPI-anchoring pathway component targeted by HCMV.
    Kol I, Rishiq A, Cohen M, Kahlon S, Pick O, Dassa L, Stein N, Bar-On Y, Wolf DG, Seidel E, Mandelboim O., Free PMC Article

    07/5/2023
    Functional characterization of 5p15.33 risk locus in uveal melanoma reveals rs452384 as a functional variant and NKX2.4 as an allele-specific interactor.

    Functional characterization of 5p15.33 risk locus in uveal melanoma reveals rs452384 as a functional variant and NKX2.4 as an allele-specific interactor.
    Derrien AC, Houy A, Ganier O, Dingli F, Ningarhari M, Mobuchon L, Espejo Díaz MI, Loew D, Cassoux N, Cussenot O, Cancel-Tassin G, Margueron R, Noirel J, Zucman-Rossi J, Rodrigues M, Stern MH., Free PMC Article

    12/17/2022
    CLPTM1L induces estrogen receptor beta signaling-mediated radioresistance in non-small cell lung cancer cells.

    CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells.
    Li H, Che J, Jiang M, Cui M, Feng G, Dong J, Zhang S, Lu L, Liu W, Fan S., Free PMC Article

    09/11/2021
    Genetic variation in cervical preinvasive and invasive disease: a genome-wide association study.

    Genetic variation in cervical preinvasive and invasive disease: a genome-wide association study.
    Bowden SJ, Bodinier B, Kalliala I, Zuber V, Vuckovic D, Doulgeraki T, Whitaker MD, Wielscher M, Cartwright R, Tsilidis KK, Bennett P, Jarvelin MR, Flanagan JM, Chadeau-Hyam M, Kyrgiou M, FinnGen consortium., Free PMC Article

    04/17/2021
    Both TERT-rs33963617 and CLPTM1L-rs77518573 conferred reduced risk for Non small cell lung cancer in Chinese Han population.

    TERT-rs33963617 and CLPTM1L-rs77518573 reduce the risk of non-small cell lung cancer in Chinese population.
    Ji Z, Li Y, Xiang C, Luo X, Yuan P, Long J, Shen N, Shen Y, Deng L, Li J, Cheng L.

    02/29/2020
    rs2736100 in CLPTM1L is associated with the risk of pharynx-larynx cancer.

    Polymorphisms of the TERT-CLPTM1L Gene Are Associated with Pharynx-Larynx Cancer.
    Yu J, Li X, Zhou B, Yan A.

    10/5/2019
    Study in human pancreatic ductal adenocarcinoma cells revealed surface relocalization and survival signaling by CLPTM1L triggered by endoplasmic reticulum (ER) stress and demonstrated interaction of CLPTM1L with GRP78. Both chemoresistance and GRP78 interaction were dependent on the extracellular loop of CLPTM1L.

    CLPTM1L/CRR9 ectodomain interaction with GRP78 at the cell surface signals for survival and chemoresistance upon ER stress in pancreatic adenocarcinoma cells.
    Clarke WR, Amundadottir L, James MA.

    06/8/2019
    rs401681 and rs402710 single nucleotide polymorphism of CLPTM1L might be the causal SNPs for lung cancer in East Asian

    rs401681 and rs402710 confer lung cancer susceptibility by regulating TERT expression instead of CLPTM1L in East Asian populations.
    Yang YC, Fu WP, Zhang J, Zhong L, Cai SX, Sun C.

    04/27/2019
    using multivariate logistic regression, we observed that haplotype CLPTM1L is significantly associated with poor treatment response

    Association of TERT-CLPTM1L and 8q24 Common Genetic Variants with Gallbladder Cancer Susceptibility and Prognosis in North Indian Population.
    Yadav S, Chandra A, Kumar A, Mittal B.

    08/18/2018
    research seems to provide strong evidence for an association between CLPTM1L rs402710C/T and TERT rs2736100A/C SNPs and the risk of OSSC, and suggests that higher tumor RTL values and positive hTERT expression may be applicable as early prognostic markers

    The role of TERT-CLPTM1L SNPs, hTERT expression and telomere length in the pathogenesis of oral squamous cell carcinoma.
    Carkic J, Nikolic N, Radojevic-Skodric S, Kuzmanovic-Pficer J, Brajovic G, Antunovic M, Milasin J, Popovic B.

    11/18/2017
    Homozygous carriers of the CLPTM1L minor C allele presented with faster 6 years telomeres shortening rate compared to carriers of the major allele.

    Genetically determined telomeres shortening is associated with carotid atherosclerosis progression and increased incidence of cardiovascular events.
    Baragetti A, Palmen J, Garlaschelli K, Grigore L, Humphries SE, Talmud PJ, Catapano AL, Norata GD.

    10/21/2017
    Variant in CLPTM1L gene is associated with lung cancer susceptibility.

    Fine mapping of chromosome 5p15.33 identifies novel lung cancer susceptibility loci in Han Chinese.
    Dong J, Cheng Y, Zhu M, Wen Y, Wang C, Wang Y, Geng L, Shen W, Liu J, Li Z, Zhang J, Ma H, Dai J, Jin G, Hu Z, Shen H.

    10/14/2017
    CLPTM1L and TERT have been implicated in cancers, and CIITA is considered as the "master control factor" for the expression of NPC-associated MHC class II genes. These suggested that both SNPs might be functional. Altogether, our findings expand our understanding of the genetic contribution to nasopharyngeal carcinoma (NPC), risk and provide novel biological insights into NPC pathogenesis.

    An extended genome-wide association study identifies novel susceptibility loci for nasopharyngeal carcinoma.
    Cui Q, Feng QS, Mo HY, Sun J, Xia YF, Zhang H, Foo JN, Guo YM, Chen LZ, Li M, Liu WS, Xu M, Zhou G, He F, Yu X, Jia WH, Liu J, Zeng YX, Bei JX.

    07/15/2017
    A case-control study examined the potential association of 4 CLPTM1L SNPs (rs4975616, rs402710, rs401681, and rs31489) with lung cancer in a Chinese Han population. Minor alleles of all four were significantly associated with decreased lung cancer risk.

    CLPTM1L polymorphism as a protective factor for lung cancer: a case-control study in southern Chinese population.
    Jin T, Li B, He N, Zhang Y, Xia R, Kang L, Ding Y, Yuan D.

    02/18/2017
    The data demonstrate that CLPTM1L overexpression can predict poor prognosis in patients with lung cancer and suggest that CLPTM1L might be associated with the regulation of cell migration and invasion.

    Prognostic significance of CLPTM1L expression and its effects on migration and invasion of human lung cancer cells.
    Ni Z, Chen Q, Lai Y, Wang Z, Sun L, Luo X, Wang X.

    12/31/2016
    Data suggest that single nucleotide polymorphisms (SNPs) in the telomerase (TERT)-cleft lip and palate transmembrane protein 1-like protein (CLPTM1L) locus may play a role in mediating the susceptibility to nasopharyngeal carcinoma (NPC) in Chinese.

    Common variations in TERT-CLPTM1L locus are reproducibly associated with the risk of nasopharyngeal carcinoma in Chinese populations.
    Zhang Y, Zhang X, Zhang H, Zhai Y, Wang Z, Li P, Yu L, Xia X, Zhang Y, Zeng Y, He F, Zhou G., Free PMC Article

    11/12/2016
    CLPTM1L Polymorphism is associated with Nasopharyngeal Carcinoma.

    A GWAS Meta-analysis and Replication Study Identifies a Novel Locus within CLPTM1L/TERT Associated with Nasopharyngeal Carcinoma in Individuals of Chinese Ancestry.
    Bei JX, Su WH, Ng CC, Yu K, Chin YM, Lou PJ, Hsu WL, McKay JD, Chen CJ, Chang YS, Chen LZ, Chen MY, Cui Q, Feng FT, Feng QS, Guo YM, Jia WH, Khoo AS, Liu WS, Mo HY, Pua KC, Teo SH, Tse KP, Xia YF, Zhang H, Zhou GQ, Liu JJ, Zeng YX, Hildesheim A, International Nasopharyngeal Carcinoma (NPC) Genetics Working Group., Free PMC Article

    10/29/2016
    This meta-analysis suggests that T allele of CLPTM1L-telomerase reverse transcriptase rs401681 polymorphism is associated with an increased PC risk, especially among Chinese.

    Association between CLPTM1L-TERT rs401681 polymorphism and risk of pancreatic cancer: a meta-analysis.
    Liu CL, Zang XX, Wang C, Kong YL, Zhang H, Zhang HY.

    07/30/2016
    rs2736100 on TERT-CLPTM1L indicates a poor prognosis for lung cancer in the Chinese Han population.

    Association of genetic polymorphisms in TERT-CLPTM1L with lung cancer in a Chinese population.
    Liu SG, Ma L, Cen QH, Huang JS, Zhang JX, Zhang JJ.

    02/6/2016
    Whole exome sequencing followed by immunohistochemistry of fibrolamellar hepatocellular carcinoma cell lines and tumors showed two structural variants resulting in fusion transcripts: DNAJB1-PRKCA and CLPTM1L-GLIS3.

    Genomic analysis of fibrolamellar hepatocellular carcinoma.
    Xu L, Hazard FK, Zmoos AF, Jahchan N, Chaib H, Garfin PM, Rangaswami A, Snyder MP, Sage J., Free PMC Article

    08/29/2015
    miR-494 regulates cell growth, invasion and apoptosis of esophageal squamous cell carcinoma cells by targeting CLPTM1L.

    Upregulation of miR-494 Inhibits Cell Growth and Invasion and Induces Cell Apoptosis by Targeting Cleft Lip and Palate Transmembrane 1-Like in Esophageal Squamous Cell Carcinoma.
    Zhang R, Chen X, Zhang S, Zhang X, Li T, Liu Z, Wang J, Zang W, Wang Y, Du Y, Zhao G.

    08/1/2015
    This study showed that genetic variation rs31489 in 5p15.33 was directly associated with the reduced risk of lung cancer in Han Chinese. The CLPTM1L gene rs31489-A allele was a protective factor for the development of lung cancer only in nonsmokers.

    Genetic variant in CLPTM1L confers reduced risk of lung cancer: a replication study in Chinese and a meta-analysis.
    Luo X, Lamsal LP, Xu WJ, Lu J, Lu YJ, Shen Y, Guan Q.

    07/25/2015
    CLPTM1L-rs401681 polymorphism was not associated with lung cancer risk in Chinese males.

    Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer: a case-control study in northeast Chinese male population.
    Zhang Y, Zhao M, Shen L, Ren Y, Su L, Li X, Yin Z, Zhou B.

    07/25/2015
    Six independent risk neoplasm loci marked by common single-nucleotide polymorphisms have been found: five in the TERT gene, and one in CLPTM1L gene, both on chromosome 5.

    Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.
    Wang Z, Zhu B, Zhang M, Parikh H, Jia J, Chung CC, Sampson JN, Hoskins JW, Hutchinson A, Burdette L, Ibrahim A, Hautman C, Raj PS, Abnet CC, Adjei AA, Ahlbom A, Albanes D, Allen NE, Ambrosone CB, Aldrich M, Amiano P, Amos C, Andersson U, Andriole G Jr, Andrulis IL, Arici C, Arslan AA, Austin MA, Baris D, Barkauskas DA, Bassig BA, Beane Freeman LE, Berg CD, Berndt SI, Bertazzi PA, Biritwum RB, Black A, Blot W, Boeing H, Boffetta P, Bolton K, Boutron-Ruault MC, Bracci PM, Brennan P, Brinton LA, Brotzman M, Bueno-de-Mesquita HB, Buring JE, Butler MA, Cai Q, Cancel-Tassin G, Canzian F, Cao G, Caporaso NE, Carrato A, Carreon T, Carta A, Chang GC, Chang IS, Chang-Claude J, Che X, Chen CJ, Chen CY, Chen CH, Chen C, Chen KY, Chen YM, Chokkalingam AP, Chu LW, Clavel-Chapelon F, Colditz GA, Colt JS, Conti D, Cook MB, Cortessis VK, Crawford ED, Cussenot O, Davis FG, De Vivo I, Deng X, Ding T, Dinney CP, Di Stefano AL, Diver WR, Duell EJ, Elena JW, Fan JH, Feigelson HS, Feychting M, Figueroa JD, Flanagan AM, Fraumeni JF Jr, Freedman ND, Fridley BL, Fuchs CS, Gago-Dominguez M, Gallinger S, Gao YT, Gapstur SM, Garcia-Closas M, Garcia-Closas R, Gastier-Foster JM, Gaziano JM, Gerhard DS, Giffen CA, Giles GG, Gillanders EM, Giovannucci EL, Goggins M, Gokgoz N, Goldstein AM, Gonzalez C, Gorlick R, Greene MH, Gross M, Grossman HB, Grubb R 3rd, Gu J, Guan P, Haiman CA, Hallmans G, Hankinson SE, Harris CC, Hartge P, Hattinger C, Hayes RB, He Q, Helman L, Henderson BE, Henriksson R, Hoffman-Bolton J, Hohensee C, Holly EA, Hong YC, Hoover RN, Hosgood HD 3rd, Hsiao CF, Hsing AW, Hsiung CA, Hu N, Hu W, Hu Z, Huang MS, Hunter DJ, Inskip PD, Ito H, Jacobs EJ, Jacobs KB, Jenab M, Ji BT, Johansen C, Johansson M, Johnson A, Kaaks R, Kamat AM, Kamineni A, Karagas M, Khanna C, Khaw KT, Kim C, Kim IS, Kim JH, Kim YH, Kim YC, Kim YT, Kang CH, Jung YJ, Kitahara CM, Klein AP, Klein R, Kogevinas M, Koh WP, Kohno T, Kolonel LN, Kooperberg C, Kratz CP, Krogh V, Kunitoh H, Kurtz RC, Kurucu N, Lan Q, Lathrop M, Lau CC, Lecanda F, Lee KM, Lee MP, Le Marchand L, Lerner SP, Li D, Liao LM, Lim WY, Lin D, Lin J, Lindstrom S, Linet MS, Lissowska J, Liu J, Ljungberg B, Lloreta J, Lu D, Ma J, Malats N, Mannisto S, Marina N, Mastrangelo G, Matsuo K, McGlynn KA, McKean-Cowdin R, McNeill LH, McWilliams RR, Melin BS, Meltzer PS, Mensah JE, Miao X, Michaud DS, Mondul AM, Moore LE, Muir K, Niwa S, Olson SH, Orr N, Panico S, Park JY, Patel AV, Patino-Garcia A, Pavanello S, Peeters PH, Peplonska B, Peters U, Petersen GM, Picci P, Pike MC, Porru S, Prescott J, Pu X, Purdue MP, Qiao YL, Rajaraman P, Riboli E, Risch HA, Rodabough RJ, Rothman N, Ruder AM, Ryu JS, Sanson M, Schned A, Schumacher FR, Schwartz AG, Schwartz KL, Schwenn M, Scotlandi K, Seow A, Serra C, Serra M, Sesso HD, Severi G, Shen H, Shen M, Shete S, Shiraishi K, Shu XO, Siddiq A, Sierrasesumaga L, Sierri S, Loon Sihoe AD, Silverman DT, Simon M, Southey MC, Spector L, Spitz M, Stampfer M, Stattin P, Stern MC, Stevens VL, Stolzenberg-Solomon RZ, Stram DO, Strom SS, Su WC, Sund M, Sung SW, Swerdlow A, Tan W, Tanaka H, Tang W, Tang ZZ, Tardon A, Tay E, Taylor PR, Tettey Y, Thomas DM, Tirabosco R, Tjonneland A, Tobias GS, Toro JR, Travis RC, Trichopoulos D, Troisi R, Truelove A, Tsai YH, Tucker MA, Tumino R, Van Den Berg D, Van Den Eeden SK, Vermeulen R, Vineis P, Visvanathan K, Vogel U, Wang C, Wang C, Wang J, Wang SS, Weiderpass E, Weinstein SJ, Wentzensen N, Wheeler W, White E, Wiencke JK, Wolk A, Wolpin BM, Wong MP, Wrensch M, Wu C, Wu T, Wu X, Wu YL, Wunder JS, Xiang YB, Xu J, Yang HP, Yang PC, Yatabe Y, Ye Y, Yeboah ED, Yin Z, Ying C, Yu CJ, Yu K, Yuan JM, Zanetti KA, Zeleniuch-Jacquotte A, Zheng W, Zhou B, Mirabello L, Savage SA, Kraft P, Chanock SJ, Yeager M, Landi MT, Shi J, Chatterjee N, Amundadottir LT., Free PMC Article

    07/25/2015
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