| Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold. | Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold.
Albisetti GW, Ganley RP, Pietrafesa F, Werynska K, Magalhaes de Sousa M, Sipione R, Scheurer L, Bösl MR, Pelczar P, Wildner H, Zeilhofer HU., Free PMC Article | 01/14/2023 |
| A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction. | A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction.
Zhang X, Liao C, Sun K, Liu L, Xu D. | 04/24/2021 |
| These findings establish MG53 as a novel regulator of KChIP2 and Ito,f by modulating NF-kappaB activity and reveal its critical role in electrophysiological remodeling in cardiac hypertrophy. | MG53, A Novel Regulator of KChIP2 and I(to,f), Plays a Critical Role in Electrophysiological Remodeling in Cardiac Hypertrophy.
Liu W, Wang G, Zhang C, Ding W, Cheng W, Luo Y, Wei C, Liu J. | 02/15/2020 |
| we are investigating the effects of hyperoxia on atrial electrophysiology using whole-cell patch-clamp electrophysiology experiments along with assessment of Kv1.5, Kv4.2, and KChIP2 transcripts and protein profiles using real-time quantitative RT-PCR and Western blotting. | Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes.
Vysotskaya Z, Chidipi B, Rodgers JL, Tang X, Samal E, Kolliputi N, Mohapatra S, Bennett ES, Panguluri SK. | 02/23/2019 |
| although there is a baseline presence of KChIP2 in the nucleus both in vivo and in vitro, KChIP2 does not directly regulate transcriptional activity. Moreover, the nuclear transport of KChIP2 is not dependent on Ca(2+). Thus, KChIP2 does not function as a conventional transcription factor in the heart. | Potassium Channel Interacting Protein 2 (KChIP2) is not a transcriptional regulator of cardiac electrical remodeling.
Winther SV, Tuomainen T, Borup R, Tavi P, Antoons G, Thomsen MB., Free PMC Article | 05/12/2018 |
| KChIP2 expression does not appear to underlie the circadian rhythm in repolarization duration. | Circadian rhythm in QT interval is preserved in mice deficient of potassium channel interacting protein 2.
Gottlieb LA, Lubberding A, Larsen AP, Thomsen MB. | 01/20/2018 |
| the Kv4.2/KChIP2 interaction in cardiomyocytes is highly dynamic, with a clear KChIP2 gene dosage effect on Kv4 channel surface expression but not on inactivation gating. | KChIP2 genotype dependence of transient outward current (Ito) properties in cardiomyocytes isolated from male and female mice.
Waldschmidt L, Junkereit V, Bähring R., Free PMC Article | 08/12/2017 |
| The downregulation of repolarizing currents in heart failure is accentuated in KChIP2(-/-) mice. | Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice.
Grubb S, Speerschneider T, Occhipinti D, Fiset C, Olesen SP, Thomsen MB, Calloe K. | 04/25/2015 |
| Real-time RT-PCR and Western blotting revealed that Kv4.2 expression was downregulated in both BSO-treated groups, whereas KChIP2 expression was downregulated only in the H/M-Sod2(+/-)+BSO group (P<0.05). | Cardiomyocyte-derived mitochondrial superoxide causes myocardial electrical remodeling by downregulating potassium channels and related molecules.
Kurokawa S, Niwano S, Niwano H, Murakami M, Ishikawa S, Masaki Y, Tamaki H, Toda T, Noda Y, Shimizu T, Izumi T, Ako J. | 04/4/2015 |
| Development of heart failure is independent of K+ channel-interacting protein 2 expression. | Development of heart failure is independent of K+ channel-interacting protein 2 expression.
Speerschneider T, Grubb S, Metoska A, Olesen SP, Calloe K, Thomsen MB., Free PMC Article | 08/23/2014 |
| KChIP2 is essential for physiologic somatodendritic potassium current modulation and homeostatic stability. | The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability.
Wang HG, He XP, Li Q, Madison RD, Moore SD, McNamara JO, Pitt GS., Free PMC Article | 07/13/2013 |
| The combined down-regulation of Kv4.2, Kv1.5 and KChIP2 prior to the onset of HF may play an important role in the premature sudden death in this DCM model. | Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy.
Suzuki T, Shioya T, Murayama T, Sugihara M, Odagiri F, Nakazato Y, Nishizawa H, Chugun A, Sakurai T, Daida H, Morimoto S, Kurebayashi N., Free PMC Article | 09/1/2012 |
| KChIP2 differentially regulates total and cell surface Kv4.2 protein expression and Kv4 current densities. | Co-assembly of Kv4 {alpha} subunits with K+ channel-interacting protein 2 stabilizes protein expression and promotes surface retention of channel complexes.
Foeger NC, Marionneau C, Nerbonne JM., Free PMC Article | 11/27/2010 |
| KChIP2 has a role in mediating regulation of CaV1.2 | Transcriptional and electrophysiological consequences of KChIP2-mediated regulation of CaV1.2.
Thomsen MB, Foster E, Nguyen KH, Sosunov EA., Free PMC Article | 02/8/2010 |
| KChIP2 modulates multiple K(V) and Na(V) currents, these results suggest that KChIP2 is a multimodal regulator of cardiac ionic currents. | Accessory subunit KChIP2 modulates the cardiac L-type calcium current.
Thomsen MB, Wang C, Ozgen N, Wang HG, Rosen MR, Pitt GS., Free PMC Article | 01/21/2010 |
| KChIP2 transcripts were highly expressed in layer IV of the cerebral cortex and in striatum and hippocampus, but expressed at low levels in cerebellum. | Differential distribution of KChIPs mRNAs in adult mouse brain.
Xiong H, Kovacs I, Zhang Z. | 01/21/2010 |
| KChIP2 contributes to the formation of functional mouse ventricular Kv1.5 channels | KChIP2 modulates the cell surface expression of Kv 1.5-encoded K(+) channels.
Li H, Guo W, Mellor RL, Nerbonne JM. | 01/21/2010 |