| Mettl3-mediated m[6]A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration. | Mettl3-mediated m(6)A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration.
Jiang FQ, Liu K, Chen JX, Cao Y, Chen WY, Zhao WL, Song GH, Liang CQ, Zhou YM, Huang HL, Huang RJ, Zhao H, Park KS, Ju Z, Cai D, Qi XF., Free PMC Article | 12/3/2022 |
| Overexpression of Fgf16 in vivo recapitulated several of our in vitro findings, specifically the significant induction of the Ucp1 gene and UCP1 protein expression in inguinal white adipose tissue (iWAT) | In Vitro and in Vivo Analyses Reveal Profound Effects of Fibroblast Growth Factor 16 as a Metabolic Regulator.
Rulifson IC, Collins P, Miao L, Nojima D, Lee KJ, Hardy M, Gupte J, Hensley K, Samayoa K, Cam C, Rottman JB, Ollmann M, Richards WG, Li Y., Free PMC Article | 06/3/2017 |
| GATA4 is required for neonatal heart regeneration through regulation of Fgf16. | GATA4 regulates Fgf16 to promote heart repair after injury.
Yu W, Huang X, Tian X, Zhang H, He L, Wang Y, Nie Y, Hu S, Lin Z, Zhou B, Pu W, Lui KO, Zhou B. | 08/6/2016 |
| results suggest a possible mechanism whereby Fgf16 prevents angiotensin II-induced cardiac hypertrophy and fibrosis by antagonizing Fgf2; the present findings should provide new insights into the roles of Fgf signaling in cardiac remodeling | Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16.
Matsumoto E, Sasaki S, Kinoshita H, Kito T, Ohta H, Konishi M, Kuwahara K, Nakao K, Itoh N., Free PMC Article | 10/11/2014 |
| Fgf-16 gene is a target for NF-kappaB activation in the postnatal heart. | FGF-16 is a target for adrenergic stimulation through NF-kappaB activation in postnatal cardiac cells and adult mouse heart.
Sofronescu AG, Detillieux KA, Cattini PA., Free PMC Article | 09/27/2010 |
| After three generations, 25% of Fgf-16(-/Y) mice survived to adulthood, which could be reversed by reducing the contribution of the C57BL/6 genetic background by back crossing to another strain. | Embryonic survival and severity of cardiac and craniofacial defects are affected by genetic background in fibroblast growth factor-16 null mice.
Lu SY, Jin Y, Li X, Sheppard P, Bock ME, Sheikh F, Duckworth ML, Cattini PA. | 09/6/2010 |
| Fgf16 does not have a unique role in inner ear development and the Fgf16 lineage is found throughout the three cristae, in portions of the semicircular canal ducts, and in the cochlear spiral prominence epithelial cells | Fgf16(IRESCre) mice: a tool to inactivate genes expressed in inner ear cristae and spiral prominence epithelium.
Hatch EP, Urness LD, Mansour SL., Free PMC Article | 01/21/2010 |
| proliferation of embryonic cardiomyocytes was significantly decreased, indicating that Fgf16 is a growth factor for these cells | Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart.
Hotta Y, Sasaki S, Konishi M, Kinoshita H, Kuwahara K, Nakao K, Itoh N. | 01/21/2010 |
| These findings indicate FGF-16 is required for embryonic heart development in mid-gestation through its positive effect on myocardial growth. | FGF-16 is required for embryonic heart development.
Lu SY, Sheikh F, Sheppard PC, Fresnoza A, Duckworth ML, Detillieux KA, Cattini PA., Free PMC Article | 01/21/2010 |
| chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart | A myocyte enhancer factor 2 (MEF2) site located in a hypersensitive region of the FGF16 gene locus is required for preferential promoter activity in neonatal cardiac myocytes.
Sofronescu AG, Jin Y, Cattini PA. | 01/21/2010 |
| cloning of the adult mouse FGF-16 cDNA | Cloning and bacterial expression of postnatal mouse heart FGF-16.
Sontag DP, Cattini PA. | 01/21/2010 |
| Fgf16 is expressed in early inner ear development. | Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development.
Wright TJ, Hatch EP, Karabagli H, Karabagli P, Schoenwolf GC, Mansour SL. | 01/21/2010 |