| Pan-cancer mapping of single CD8[+] T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity. | Pan-cancer mapping of single CD8(+) T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity.
Tooley K, Jerby L, Escobar G, Krovi SH, Mangani D, Dandekar G, Cheng H, Madi A, Goldschmidt E, Lambden C, Krishnan RK, Rozenblatt-Rosen O, Regev A, Anderson AC., Free PMC Article | 08/16/2024 |
| CXCR6 orchestrates brain CD8[+] T cell residency and limits mouse Alzheimer's disease pathology. | CXCR6 orchestrates brain CD8(+) T cell residency and limits mouse Alzheimer's disease pathology.
Su W, Saravia J, Risch I, Rankin S, Guy C, Chapman NM, Shi H, Sun Y, Kc A, Li W, Huang H, Lim SA, Hu H, Wang Y, Liu D, Jiao Y, Chen PC, Soliman H, Yan KK, Zhang J, Vogel P, Liu X, Serrano GE, Beach TG, Yu J, Peng J, Chi H., Free PMC Article | 05/9/2024 |
| CXCR6 Mediates Pressure Overload-Induced Aortic Stiffness by Increasing Macrophage Recruitment and Reducing Exosome-miRNA29b. | CXCR6 Mediates Pressure Overload-Induced Aortic Stiffness by Increasing Macrophage Recruitment and Reducing Exosome-miRNA29b.
Wang S, Wu J, Li X, Tan R, Chen L, Yang L, Dai F, Ma L, Xu L, Wang Z, Zhao G, Ge J, Zou Y. | 05/5/2023 |
| CXCR6 expressing T cells: Functions and role in the control of tumors. | CXCR6 expressing T cells: Functions and role in the control of tumors.
Mabrouk N, Tran T, Sam I, Pourmir I, Gruel N, Granier C, Pineau J, Gey A, Kobold S, Fabre E, Tartour E., Free PMC Article | 11/5/2022 |
| Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination. | Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination.
Rosen SF, Soung AL, Yang W, Ai S, Kanmogne M, Davé VA, Artyomov M, Magee JA, Klein RS., Free PMC Article | 10/15/2022 |
| CCR6 and CXCR6 Identify the Th17 Cells With Cytotoxicity in Experimental Autoimmune Encephalomyelitis. | CCR6 and CXCR6 Identify the Th17 Cells With Cytotoxicity in Experimental Autoimmune Encephalomyelitis.
Hou L, Yuki K., Free PMC Article | 04/2/2022 |
| Murine CXCR3(+)CXCR6(+)gammadeltaT Cells Reside in the Liver and Provide Protection Against HBV Infection. | Murine CXCR3(+)CXCR6(+)γδT Cells Reside in the Liver and Provide Protection Against HBV Infection.
Wang Y, Guan Y, Hu Y, Li Y, Lu N, Zhang C., Free PMC Article | 02/26/2022 |
| CXCR6 by increasing retention of memory CD8(+) T cells in the ovarian tumor microenvironment promotes immunosurveillance and control of ovarian cancer. | CXCR6 by increasing retention of memory CD8(+) T cells in the ovarian tumor microenvironment promotes immunosurveillance and control of ovarian cancer.
Muthuswamy R, McGray AR, Battaglia S, He W, Miliotto A, Eppolito C, Matsuzaki J, Takemasa T, Koya R, Chodon T, Lichty BD, Shrikant P, Odunsi K., Free PMC Article | 01/15/2022 |
| CXCR6 is required for antitumor efficacy of intratumoral CD8(+) T cell. | CXCR6 is required for antitumor efficacy of intratumoral CD8(+) T cell.
Wang B, Wang Y, Sun X, Deng G, Huang W, Wu X, Gu Y, Tian Z, Fan Z, Xu Q, Chen H, Sun Y., Free PMC Article | 01/8/2022 |
| CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment. | CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment.
Di Pilato M, Kfuri-Rubens R, Pruessmann JN, Ozga AJ, Messemaker M, Cadilha BL, Sivakumar R, Cianciaruso C, Warner RD, Marangoni F, Carrizosa E, Lesch S, Billingsley J, Perez-Ramos D, Zavala F, Rheinbay E, Luster AD, Gerner MY, Kobold S, Pittet MJ, Mempel TR., Free PMC Article | 01/8/2022 |
| CXCR6 deficiency impairs cancer vaccine efficacy and CD8(+) resident memory T-cell recruitment in head and neck and lung tumors. | CXCR6 deficiency impairs cancer vaccine efficacy and CD8(+) resident memory T-cell recruitment in head and neck and lung tumors.
Karaki S, Blanc C, Tran T, Galy-Fauroux I, Mougel A, Dransart E, Anson M, Tanchot C, Paolini L, Gruel N, Gibault L, Lepimpec-Barhes F, Fabre E, Benhamouda N, Badoual C, Damotte D, Donnadieu E, Kobold S, Mami-Chouaib F, Golub R, Johannes L, Tartour E., Free PMC Article | 12/18/2021 |
| Auto-aggressive CXCR6(+) CD8 T cells cause liver immune pathology in NASH. | Auto-aggressive CXCR6(+) CD8 T cells cause liver immune pathology in NASH.
Dudek M, Pfister D, Donakonda S, Filpe P, Schneider A, Laschinger M, Hartmann D, Hüser N, Meiser P, Bayerl F, Inverso D, Wigger J, Sebode M, Öllinger R, Rad R, Hegenbarth S, Anton M, Guillot A, Bowman A, Heide D, Müller F, Ramadori P, Leone V, Garcia-Caceres C, Gruber T, Seifert G, Kabat AM, Mallm JP, Reider S, Effenberger M, Roth S, Billeter AT, Müller-Stich B, Pearce EJ, Koch-Nolte F, Käser R, Tilg H, Thimme R, Boettler T, Tacke F, Dufour JF, Haller D, Murray PJ, Heeren R, Zehn D, Böttcher JP, Heikenwälder M, Knolle PA. | 12/11/2021 |
| Evolutionary analysis of chemokine CXCL16 and its receptor CXCR6 in murine rodents. | Evolutionary analysis of chemokine CXCL16 and its receptor CXCR6 in murine rodents.
He D, Hu J, Yang R, Zeng B, Yang D, Li D, Zhang M, Yang M, Ni Q, Ning R, Fan X, Li X, Mao X, Li Y. | 09/4/2021 |
| Disruption of CXCR6 Ameliorates Kidney Inflammation and Fibrosis in Deoxycorticosterone Acetate/Salt Hypertension. | Disruption of CXCR6 Ameliorates Kidney Inflammation and Fibrosis in Deoxycorticosterone Acetate/Salt Hypertension.
Wu Y, An C, Jin X, Hu Z, Wang Y., Free PMC Article | 11/21/2020 |
| we have identified a unique role for the chemokine receptor CXCR6 in directing the migration of TRM cells in the lung under steady-state conditions and maintaining the airway TRM cell pool. | CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways.
Wein AN, McMaster SR, Takamura S, Dunbar PR, Cartwright EK, Hayward SL, McManus DT, Shimaoka T, Ueha S, Tsukui T, Masumoto T, Kurachi M, Matsushima K, Kohlmeier JE., Free PMC Article | 06/20/2020 |
| CXCR6 influenced the kinetics of the inflammatory response. | CXCR6-Deficiency Improves the Control of Pulmonary Mycobacterium tuberculosis and Influenza Infection Independent of T-Lymphocyte Recruitment to the Lungs.
Ashhurst AS, Flórido M, Lin LCW, Quan D, Armitage E, Stifter SA, Stambas J, Britton WJ., Free PMC Article | 05/30/2020 |
| The results provide evidence of the pathogenic role of NKT cells in fatty liver ischemia-reperfusion injury (IRI), and important localization mechanism involving up-regulated CXCR6/CXCL16. Deficiency of CXCR6 protects the fatty liver from IRI by reducing the recruitment and cytokine production of hepatic NKT cells. | CXCR6 deficiency ameliorates ischemia-reperfusion injury by reducing the recruitment and cytokine production of hepatic NKT cells in a mouse model of non-alcoholic fatty liver disease.
Zhu H, Zhang Q, Chen G. | 12/7/2019 |
| CXCL16/CXCR6 signaling axis plays a functional role in metabolic syndrome endothelial dysfunction and abdominal aortic aneurysm formation. | Functional role of endothelial CXCL16/CXCR6-platelet-leucocyte axis in angiotensin II-associated metabolic disorders.
Collado A, Marques P, Escudero P, Rius C, Domingo E, Martinez-Hervás S, Real JT, Ascaso JF, Piqueras L, Sanz MJ. | 10/26/2019 |
| Gene array analyses revealed up-regulated stress response and metabolism pathways in hepatocytes from NEMO(LPC-knockout)Cxcr6(-/-) mice. | CXCR6 protects from inflammation and fibrosis in NEMO(LPC-KO) mice.
Liepelt A, Wehr A, Kohlhepp M, Mossanen JC, Kreggenwinkel K, Denecke B, Costa IG, Luedde T, Trautwein C, Tacke F. | 09/21/2019 |
| In studies of mice with liver tumors, we found that CXCR6 mediated NKT-cell and CD4+ T-cell removal of senescent hepatocytes. | CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4(+) T-Cell-Dependent Control of Senescence.
Mossanen JC, Kohlhepp M, Wehr A, Krenkel O, Liepelt A, Roeth AA, Möckel D, Heymann F, Lammers T, Gassler N, Hermann J, Jankowski J, Neumann UP, Luedde T, Trautwein C, Tacke F. | 05/18/2019 |
| these results demonstrate an important role of CXCR6 in the regulation of pathological Th17 and IL-17A(+)TCRgammadelta(+) T-cell recruitment into atherosclerotic lesions. | CXCR6 regulates the recruitment of pro-inflammatory IL-17A-producing T cells into atherosclerotic aortas.
Butcher MJ, Wu CI, Waseem T, Galkina EV., Free PMC Article | 12/16/2017 |
| CXCR6 has a role in the circulation of innate lymphoid cell precursors and their progeny | CXCR6 Expression Is Important for Retention and Circulation of ILC Precursors.
Chea S, Possot C, Perchet T, Petit M, Cumano A, Golub R., Free PMC Article | 08/27/2016 |
| CXCR6 is essential for pressure overload-mediated myocardial recruitment of monocytes, which contributes to cardiac fibrosis through TNF-alpha-dependent MMP9 activation and collagen synthesis. | CXCR6 deficiency attenuates pressure overload-induced monocytes migration and cardiac fibrosis through downregulating TNF-α-dependent MMP9 pathway.
Wang JH, Su F, Wang S, Lu XC, Zhang SH, Chen D, Chen NN, Zhong JQ., Free PMC Article | 07/25/2015 |
| CXCR6 appears to influence long-term survival and tissue distribution of activated T cells. | The function of the chemokine receptor CXCR6 in the T cell response of mice against Listeria monocytogenes.
Heesch K, Raczkowski F, Schumacher V, Hünemörder S, Panzer U, Mittrücker HW., Free PMC Article | 06/20/2015 |
| CXCR6 deficiency inhibited total collagen deposition and suppressed the expression of collagen I and fibronectin in obstructed kidneys. | The chemokine receptor CXCR6 contributes to recruitment of bone marrow-derived fibroblast precursors in renal fibrosis.
Xia Y, Yan J, Jin X, Entman ML, Wang Y., Free PMC Article | 05/16/2015 |