| GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2 and Notch1 in pancreatic cancer. | GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2 and Notch1 in pancreatic cancer.
Han S, Cao C, Liu R, Yuan Y, Pan L, Xu M, Hu C, Zhang X, Li M, Zhang X. | 06/25/2022 |
| This study determined the crystal structure of the GAS41 YEATS domain with H3K23acK27ac to visualize the molecular basis of diacetylated histone binding. The results suggest a unique binding mode in which full-length GAS41 is a reader of diacetylated histones. | GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode.
Cho HJ, Li H, Linhares BM, Kim E, Ndoj J, Miao H, Grembecka J, Cierpicki T., Free PMC Article | 04/6/2019 |
| Cellular and structural studies revealed that GAS41 is a histone lysine succinylation reader owing to a protonated histidine residue located inside the pocket. | Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation.
Wang Y, Jin J, Chung MWH, Feng L, Sun H, Hao Q., Free PMC Article | 08/4/2018 |
| study identifies GAS41 as a histone acetylation reader that promotes histone H2A.Z deposition in non-small cell lung cancer. | Recognition of histone acetylation by the GAS41 YEATS domain promotes H2A.Z deposition in non-small cell lung cancer.
Hsu CC, Shi J, Yuan C, Zhao D, Jiang S, Lyu J, Wang X, Li H, Wen H, Li W, Shi X., Free PMC Article | 06/9/2018 |
| our study demonstrated the oncogenic roles of YEATS4 in the progression of pancreatic cancer by activating beta-catenin/TCF signaling and suggested that YEATS4 might be a promising therapeutic target for pancreatic cancer. | YEATS4 promotes the tumorigenesis of pancreatic cancer by activating beta-catenin/TCF signaling.
Jixiang C, Shengchun D, Jianguo Q, Zhengfa M, Xin F, Xuqing W, Jianxin Z, Lei C., Free PMC Article | 03/10/2018 |
| identified GAS41 as a novel target for endogenous miR-203 and demonstrate an inverse correlation of miR-203 expression with GAS41 in glioma cell lines | Regulation of Cell Proliferation and Migration by miR-203 via GAS41/miR-10b Axis in Human Glioblastoma Cells.
Pal D, Mukhopadhyay D, Ramaiah MJ, Sarma P, Bhadra U, Bhadra MP., Free PMC Article | 07/29/2017 |
| miR-218 sensitized HCT-116/L-OHP cells to L-OHP-induced cell apoptosis via inhibition of cytoprotective autophagy by targeting YEATS4 expression. | Downregulation of YEATS4 by miR-218 sensitizes colorectal cancer cells to L-OHP-induced cell apoptosis by inhibiting cytoprotective autophagy.
Fu Q, Cheng J, Zhang J, Zhang Y, Chen X, Xie J, Luo S. | 03/18/2017 |
| YEATS4 overexpression is associated with drug resistance of ovarian cancer. | Transcriptome analysis indicates TFEB1 and YEATS4 as regulatory transcription factors for drug resistance of ovarian cancer.
Kim YR, Park MS, Eum KH, Kim J, Lee JW, Bae T, Lee DH, Choi JW., Free PMC Article | 08/27/2016 |
| Findings reveal YEATS4 as a candidate oncogene amplified in NSCLC, and a novel mechanism contributing to NSCLC pathogenesis | YEATS4 is a novel oncogene amplified in non-small cell lung cancer that regulates the p53 pathway.
Pikor LA, Lockwood WW, Thu KL, Vucic EA, Chari R, Gazdar AF, Lam S, Lam WL., Free PMC Article | 05/17/2014 |
| Our data confirm previous genome-wide findings at 12q15 and suggest differential YEATS4 expression could underpin rs7297610-associated HCTZ response variability, which may have future implications for guiding thiazide treatment. | Association of chromosome 12 locus with antihypertensive response to hydrochlorothiazide may involve differential YEATS4 expression.
Duarte JD, Turner ST, Tran B, Chapman AB, Bailey KR, Gong Y, Gums JG, Langaee TY, Beitelshees AL, Cooper-Dehoff RM, Boerwinkle E, Johnson JA., Free PMC Article | 01/4/2014 |
| GAS41 amplification results in overexpression and associtated with glioblastoma. | GAS41 amplification results in overexpression of a new spindle pole protein.
Schmitt J, Fischer U, Heisel S, Strickfaden H, Backes C, Ruggieri A, Keller A, Chang P, Meese E., Free PMC Article | 12/8/2012 |
| Gas41 is able to bind both n-Myc and c-Myc proteins, and that the levels of expression of Gas41 and Myc proteins were similar to each other in such brain tumors as neuroblastomas and glioblastomas. | Direct interaction of Gas41 and Myc encoded by amplified genes in nervous system tumours.
Piccinni E, Chelstowska A, Hanus J, Widlak P, Loreti S, Tata AM, Augusti-Tocco G, Bianchi MM, Negri R. | 05/5/2012 |
| The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability | The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability.
Park JH, Smith RJ, Shieh SY, Roeder RG., Free PMC Article | 06/4/2011 |
| The in vivo interaction of GAS41 and endogenous RAP30 and RAP74 was confirmed by co-immunoprecipitation. GAS41 binds to two non-overlapping regions of the C-terminus of RAP30. | The YEATS family member GAS41 interacts with the general transcription factor TFIIF.
Heisel S, Habel NC, Schuetz N, Ruggieri A, Meese E., Free PMC Article | 09/6/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.
Turner ST, Bailey KR, Fridley BL, Chapman AB, Schwartz GL, Chai HS, Sicotte H, Kocher JP, Rodin AS, Boerwinkle E., Free PMC Article | 07/13/2008 |
| Overexpression of YEATS4 is associated with well-differentiated and dedifferentiated liposarcomas | HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon.
Italiano A, Bianchini L, Keslair F, Bonnafous S, Cardot-Leccia N, Coindre JM, Dumollard JM, Hofman P, Leroux A, Mainguené C, Peyrottes I, Ranchere-Vince D, Terrier P, Tran A, Gual P, Pedeutour F. | 01/21/2010 |
| Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells | Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells.
Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH., Free PMC Article | 01/21/2010 |
| GAS41 plays a role in repressing the p53 tumor suppressor pathway during the normal cell cycle by a TIP60-independent mechanism. | GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation.
Park JH, Roeder RG., Free PMC Article | 01/21/2010 |