| Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns. | Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns.
Hoti Q, Akan G, Tuncel G, Evren EU, Evren H, Suer K, Sanlidag T, Ergoren MC. | 03/19/2024 |
| The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case-control study. | The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case-control study.
Liang Y, Yao J, Qiu R, Chen A, Huang H, Lin H, Yu L., Free PMC Article | 11/12/2022 |
| Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor. | Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor.
Laffitte A, Belloir C, Neiers F, Briand L., Free PMC Article | 09/3/2022 |
| Relationship between the TAS2R38 and TAS1R2 polymorphisms and the dental status in obese children. | Relationship between the TAS2R38 and TAS1R2 polymorphisms and the dental status in obese children.
Kiliç M, Gurbuz T, Kahraman CY, Cayir A, Bilgiç A, Kurt Y. | 07/9/2022 |
| The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans. | The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans.
Serrano J, Seflova J, Park J, Pribadi M, Sanematsu K, Shigemura N, Serna V, Yi F, Mari A, Procko E, Pratley RE, Robia SL, Kyriazis GA., Free PMC Article | 03/26/2022 |
| Polymorphic variants in Sweet and Umami taste receptor genes and birthweight. | Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
Farinella R, Erbi I, Bedini A, Donato S, Gentiluomo M, Angelucci C, Lupetti A, Cuttano A, Moscuzza F, Tuoni C, Rizzato C, Ciantelli M, Campa D., Free PMC Article | 12/11/2021 |
| Current Progress in Understanding the Structure and Function of Sweet Taste Receptor. | Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
Yang L, Cui M, Liu B. | 10/9/2021 |
| Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor. | Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor.
Mahalapbutr P, Lee VS, Rungrotmongkol T. | 01/23/2021 |
| Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer. | Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer.
Perez-Aguilar JM, Kang SG, Zhang L, Zhou R. | 08/13/2020 |
| create several models of the orthosteric binding site of the sweet taste receptor in the hT1R2 VFT domain | Structure-based screening for discovery of sweet compounds.
Ben Shoshan-Galeczki Y, Niv MY. | 05/23/2020 |
| The data further reveal that the C terminus of the extracellular cysteine-rich domain needs to be properly folded for T1R3 dimerization and co-trafficking, but not for surface expression of T1R2 alone. These results guided the modeling of the T1R2-T1R3 dimer in living cells. | Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits.
Park J, Selvam B, Sanematsu K, Shigemura N, Shukla D, Procko E., Free PMC Article | 10/19/2019 |
| genetic association studies in population of preschool-aged children in Guelph, Ontario: Data suggest that SNPs in CD36 (rs1761667), TAS1R2 (rs35874116), and TAS2R38 (rs713598) are associated with snacking behavior in the population studied. [PILOT PROJECTS] | Single Nucleotide Polymorphisms in Taste Receptor Genes Are Associated with Snacking Patterns of Preschool-Aged Children in the Guelph Family Health Study: A Pilot Study.
Chamoun E, Hutchinson JM, Krystia O, Mirotta JA, Mutch DM, Buchholz AC, Duncan AM, Darlington G, Haines J, Ma DWL, Guelph Family Health Study., Free PMC Article | 09/1/2018 |
| We observe that binding of agonists to VFD2 of TAS1R2 leads to major conformational changes to form a TM6/TM6 interface between TMDs of TAS1R2 and TAS1R3, which is consistent with the activation process observed biophysically on the metabotropic glutamate receptor 2 homodimer. | Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists.
Kim SK, Chen Y, Abrol R, Goddard WA 3rd, Guthrie B., Free PMC Article | 04/21/2018 |
| Alleles from each TAS1R2 locus (GG compared with AA alleles of rs12033832, and CT/CC compared with TT alleles of rs35874116) were related to higher consumption of carbohydrates (% energy) and higher amount of sweet foods, respectively (P<0.05). | Salivary leptin and TAS1R2/TAS1R3 polymorphisms are related to sweet taste sensitivity and carbohydrate intake from a buffet meal in healthy young adults.
Han P, Keast RSJ, Roura E. | 12/16/2017 |
| The molecular anatomy of sweet taste receptor dimers T1R2-T1R3 has been presented. | The anatomy of mammalian sweet taste receptors.
Chéron JB, Golebiowski J, Antonczak S, Fiorucci S. | 06/24/2017 |
| no significant associations between GLUT2 and/or TAS1R2 polymorphisms and fillings were found, but allele frequencies of the TAS1R2 variant were marginally significantly different between children with DMFT = 0 and DMFT >/=1. no significant interaction between both genes and risk of dental caries was found. GLUT2 and TASR1 polymorphisms may influence the risk of caries in the Czech population | GLUT2 and TAS1R2 Polymorphisms and Susceptibility to Dental Caries.
Izakovicova Holla L, Borilova Linhartova P, Lucanova S, Kastovsky J, Musilova K, Bartosova M, Kukletova M, Kukla L, Dusek L. | 12/24/2016 |
| In conclusion, the Val/Val genotype of TAS1R2 was associated with a higher carbohydrate intake and HTG. | Sweet Taste Receptor TAS1R2 Polymorphism (Val191Val) Is Associated with a Higher Carbohydrate Intake and Hypertriglyceridemia among the Population of West Mexico.
Ramos-Lopez O, Panduro A, Martinez-Lopez E, Roman S., Free PMC Article | 10/29/2016 |
| high-risk caries experience (>8 caries) was found to be associated with TAS1R2 rs35874116 homozygous polymorphic genotype. | Association of sweet taste receptor gene polymorphisms with dental caries experience in school children.
Haznedaroğlu E, Koldemir-Gündüz M, Bakır-Coşkun N, Bozkuş HM, Çağatay P, Süsleyici-Duman B, Menteş A. | 07/30/2016 |
| The rs12033832 single nucleotide polymorphism in TAS1R2 is associated with sucrose taste and sugar intake, but the effect differs depending on BMI | Variation in the TAS1R2 Gene, Sweet Taste Perception and Intake of Sugars.
Dias AG, Eny KM, Cockburn M, Chiu W, Nielsen DE, Duizer L, El-Sohemy A. | 06/28/2016 |
| human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3 | Distinct human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3.
Shimizu M, Goto M, Kawai T, Yamashita A, Kusakabe Y., Free PMC Article | 03/21/2015 |
| effects of artificial sweeteners on adipose tissue may be largely independent of the classical sweet taste receptors, T1R2 and T1R3 | Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors.
Simon BR, Parlee SD, Learman BS, Mori H, Scheller EL, Cawthorn WP, Ning X, Gallagher K, Tyrberg B, Assadi-Porter FM, Evans CR, MacDougald OA., Free PMC Article | 01/25/2014 |
| Interaction between brazzein and the amino terminal domain of the sweet receptor subunit T1R2 showed a stronger interaction at 7 degrees C than at 37 degrees C.; the low temperature conformation, alters the orientations of 2 loops known to be critical for the sweetness of brazzein, may represent the bound state of brazzei in the complex with the human sweet receptor. | Temperature-dependent conformational change affecting Tyr11 and sweetness loops of brazzein.
Cornilescu CC, Cornilescu G, Rao H, Porter SF, Tonelli M, DeRider ML, Markley JL, Assadi-Porter FM., Free PMC Article | 12/14/2013 |
| associated with caries risk | Association of GLUT2 and TAS1R2 genotypes with risk for dental caries.
Kulkarni GV, Chng T, Eny KM, Nielsen D, Wessman C, El-Sohemy A. | 10/19/2013 |
| Genetic ablation of the sweet TR protein T1R2 obliterates fructose-induced insulin release and its potentiating effects on glucose-stimulated insulin secretion in vitro and in vivo. | Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion.
Kyriazis GA, Soundarapandian MM, Tyrberg B., Free PMC Article | 04/14/2012 |
| T1R2/T1R3 is involved in glucose-dependent secretion of satiation peptides | The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans.
Gerspach AC, Steinert RE, Schönenberger L, Graber-Maier A, Beglinger C. | 10/1/2011 |