| Functional Role of AKNA: A Scoping Review. | Functional Role of AKNA: A Scoping Review.
Ramírez-González A, Manzo-Merino J, Contreras-Ochoa CO, Bahena-Román M, Aguilar-Villaseñor JM, Lagunas-Martínez A, Rosenstein Y, Madrid Marina V, Torres-Poveda K., Free PMC Article | 07/29/2024 |
| Critical Role of the Transcription Factor AKNA in T-Cell Activation: An Integrative Bioinformatics Approach. | Critical Role of the Transcription Factor AKNA in T-Cell Activation: An Integrative Bioinformatics Approach.
Ramírez-González A, Ávila-López P, Bahena-Román M, Contreras-Ochoa CO, Lagunas-Martínez A, Langley E, Manzo-Merino J, Madrid-Marina V, Torres-Poveda K., Free PMC Article | 02/28/2023 |
| A Homozygous AKNA Frameshift Variant Is Associated with Microcephaly in a Pakistani Family. | A Homozygous AKNA Frameshift Variant Is Associated with Microcephaly in a Pakistani Family.
Waseem SS, Moawia A, Budde B, Tariq M, Khan A, Ali Z, Khan S, Iqbal M, Malik NA, Haque SU, Altmüller J, Thiele H, Hussain MS, Cirak S, Baig SM, Nürnberg P., Free PMC Article | 02/12/2022 |
| AKNA Is a Potential Prognostic Biomarker in Gastric Cancer and Function as a Tumor Suppressor by Modulating EMT-Related Pathways. | AKNA Is a Potential Prognostic Biomarker in Gastric Cancer and Function as a Tumor Suppressor by Modulating EMT-Related Pathways.
Wang G, Sun D, Li W, Xin Y., Free PMC Article | 03/13/2021 |
| Evaluation of Common Variants in the AKNA Gene and Susceptibility to Knee Osteoarthritis Among the Han Chinese. | Evaluation of Common Variants in the AKNA Gene and Susceptibility to Knee Osteoarthritis Among the Han Chinese.
Zhao T, Ma C, Xie B, Zhao B, Wang W, Liu J. | 02/27/2021 |
| An exome-first approach to aid in the diagnosis of primary ciliary dyskinesia. | An exome-first approach to aid in the diagnosis of primary ciliary dyskinesia.
Shamseldin HE, Al Mogarri I, Alqwaiee MM, Alharbi AS, Baqais K, AlSaadi M, AlAnzi T, Alhashem A, Saghier A, Ameen W, Ibrahim N, Yang J, Abdulwahab F, Hashem M, Chivukula RR, Alkuraya FS. | 09/26/2020 |
| We studied the expression profile of the 60 genes located at that genomic region. POLE3 and AKNA were the only two genes deregulated in resistant tumors harboring the 9q32-q33.1 gain | Orthoxenografts of Testicular Germ Cell Tumors Demonstrate Genomic Changes Associated with Cisplatin Resistance and Identify PDMP as a Resensitizing Agent.
Piulats JM, Vidal A, García-Rodríguez FJ, Muñoz C, Nadal M, Moutinho C, Martínez-Iniesta M, Mora J, Figueras A, Guinó E, Padullés L, Aytés À, Molleví DG, Puertas S, Martínez-Fernández C, Castillo W, Juliachs M, Moreno V, Muñoz P, Stefanovic M, Pujana MA, Condom E, Esteller M, Germà JR, Capella G, Farré L, Morales A, Viñals F, García-Del-Muro X, Cerón J, Villanueva A. | 12/21/2019 |
| Epithelial-like neural stem cells divide in the ventricular zone at the ventricles of the embryonic brain, self-renew and generate basal progenitors that delaminate and settle in the subventricular zone in enlarged brain regions; the length of time that cells stay in the subventricular zone is essential for controlling further amplification and fate determination; interphase AKNA has a key role in this process | The centrosome protein AKNA regulates neurogenesis via microtubule organization.
Camargo Ortega G, Falk S, Johansson PA, Peyre E, Broix L, Sahu SK, Hirst W, Schlichthaerle T, De Juan Romero C, Draganova K, Vinopal S, Chinnappa K, Gavranovic A, Karakaya T, Steininger T, Merl-Pham J, Feederle R, Shao W, Shi SH, Hauck SM, Jungmann R, Bradke F, Borrell V, Geerlof A, Reber S, Tiwari VK, Huttner WB, Wilsch-Bräuninger M, Nguyen L, Götz M. | 08/10/2019 |
| Authors suggest that regulatory and coding polymorphisms of the inflammatory modulator gene AKNA can influence the development of KOA. | The association of AKNA gene polymorphisms with knee osteoarthritis suggests the relevance of this immune response regulator in the disease genetic susceptibility.
Martínez-Nava GA, Fernández-Torres J, Martínez-Flores K, Zamudio-Cuevas Y, Clavijo-Cornejo D, Espinosa-Morales R, Lozada CA, Gutierrez M, Granados J, Pineda C, Madrid-Marina V, López-Reyes A. | 07/21/2018 |
| identified HIF1A Pro582Ser T allele and C/T genotype as well as AKNA -1372C>A polymorphism A/A genotype as genetic factors associated with Primary Sjogren's Syndrome. | HIF1A (rs11549465) and AKNA (rs10817595) Gene Polymorphisms Are Associated with Primary Sjögren's Syndrome.
Hernández-Molina G, Rodríguez-Pérez JM, Fernández-Torres J, Lima G, Pérez-Hernández N, López-Reyes A, Martínez-Nava GA., Free PMC Article | 02/17/2018 |
| Results support the hypothesis that akna is a cervical cancer susceptibility genetic factor and suggest that akna transcriptional regulation has a role in the disease; identified an association between high akna expression levels and cervical cancer and squamous intraepithelial lesion, but its direction differs in each disease stage. | Cervical cancer-associated promoter polymorphism affects akna expression levels.
Martínez-Nava GA, Torres-Poveda K, Lagunas-Martínez A, Bahena-Román M, Zurita-Díaz MA, Ortíz-Flores E, García-Carrancá A, Madrid-Marina V, Burguete-García AI. | 08/8/2015 |
| significantly decreased expression of CD18 and AKNA suggests a role for both proteins in the pathogenesis of Vogt-Koyanagi-Harada syndrome | Label-free proteomics reveals decreased expression of CD18 and AKNA in peripheral CD4+ T cells from patients with Vogt-Koyanagi-Harada syndrome.
Mao L, Yang P, Hou S, Li F, Kijlstra A., Free PMC Article | 08/6/2011 |
| Data indicate that AKNA appears to be an important genetic factor associated with the risk cervical cancer. | A polymorphism in the AT-hook motif of the transcriptional regulator AKNA is a risk factor for cervical cancer.
Perales G, Burguete-García AI, Dimas J, Bahena-Román M, Bermúdez-Morales VH, Moreno J, Madrid-Marina V, Perales G, Burguete-García AI, Dimas J, Bahena-Román M, Bermúdez-Morales VH, Moreno J, Madrid-Marina V. | 10/30/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesA polymorphism in the AT-hook motif of the transcriptional regulator AKNA is a risk factor for cervical cancer.
Perales G, Burguete-García AI, Dimas J, Bahena-Román M, Bermúdez-Morales VH, Moreno J, Madrid-Marina V, Perales G, Burguete-García AI, Dimas J, Bahena-Román M, Bermúdez-Morales VH, Moreno J, Madrid-Marina V. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 06/30/2010 |
| AKNA expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation. | The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation.
Sims-Mourtada JC, Bruce S, McKeller MR, Rangel R, Guzman-Rojas L, Cain K, Lopez C, Zimonjic DB, Popescu NC, Gordon J, Wilkinson MF, Martinez-Valdez H. | 01/21/2010 |