| Bioactive Vitamin D Attenuates MED28-Mediated Cell Growth and Epithelial-Mesenchymal Transition in Human Colorectal Cancer Cells. | Bioactive Vitamin D Attenuates MED28-Mediated Cell Growth and Epithelial-Mesenchymal Transition in Human Colorectal Cancer Cells.
Huang CY, Weng YT, Hsieh NT, Li PC, Lee TY, Li CI, Liu HS, Lee MF., Free PMC Article | 09/17/2022 |
| Highly expressed lncRNA FOXD3-AS1 promotes non-small cell lung cancer progression via regulating miR-127-3p/mediator complex subunit 28 axis. | Highly expressed lncRNA FOXD3-AS1 promotes non-small cell lung cancer progression via regulating miR-127-3p/mediator complex subunit 28 axis.
Zeng ZL, Zhu HK, He LF, Xu X, Xie A, Zheng EK, Ni JJ, Liu JT, Zhao GF. | 03/20/2021 |
| RCOR1 directly binds to MED28 and weakens its inducing effect on cancer stem cell-like activity of oral cavity squamous cell carcinoma cells. | RCOR1 directly binds to MED28 and weakens its inducing effect on cancer stem cell-like activity of oral cavity squamous cell carcinoma cells.
Xiang Z, Zhou S, Liang S, Zhang G, Tan Y. | 12/26/2020 |
| The data indicate that MED28 interacts with FOXM1, and each affects the expression and localization of the other, and, more importantly, both regulate MMP2-dependent migration and invasion in human lung cancer cells. | MED28 and forkhead box M1 (FOXM1) mediate matrix metalloproteinase 2 (MMP2)-dependent cellular migration in human nonsmall cell lung cancer (NSCLC) cells.
Hsieh NT, Huang CY, Li CC, Wang IC, Lee MF. | 05/9/2020 |
| Results suggest that MED28 expression is increased by oncogenic transcription factors and its overexpression disturbs the cell cycle, which results in genomic instability and aneuploidy. | MED28 Over-Expression Shortens the Cell Cycle and Induces Genomic Instability.
Cho JG, Choi JS, Lee JH, Cho MG, Kim HS, Noh HD, Lim KH, Park B, Kim JO, Park SG., Free PMC Article | 08/17/2019 |
| MED28 modulates the development of epithelial-mesenchymal transition through NFkappaB in human breast cancer cells. | MED28 Regulates Epithelial-Mesenchymal Transition Through NFκB in Human Breast Cancer Cells.
Huang CY, Hsieh NT, Li CI, Weng YT, Liu HS, Lee MF. | 05/20/2017 |
| All trans-retinoic acid can reverse the suppressive effect of MED28 on HBP1 and E-cadherin and inactivate the Wnt/beta-catenin pathway in colorectal cancer, suggesting a protective effect of ATRA against colorectal cancer. | All Trans-Retinoic Acid Mediates MED28/HMG Box-Containing Protein 1 (HBP1)/β-Catenin Signaling in Human Colorectal Cancer Cells.
Lee MF, Hsieh NT, Huang CY, Li CI. | 09/3/2016 |
| This paper describes a link between Med23 and IFN-lambda3, provides evidence for the crucial role of IFN-lambda in HSV-1 immune control. | A systematic analysis of host factors reveals a Med23-interferon-λ regulatory axis against herpes simplex virus type 1 replication.
Griffiths SJ, Koegl M, Boutell C, Zenner HL, Crump CM, Pica F, Gonzalez O, Friedel CC, Barry G, Martin K, Craigon MH, Chen R, Kaza LN, Fossum E, Fazakerley JK, Efstathiou S, Volpi A, Zimmer R, Ghazal P, Haas J., Free PMC Article | 03/22/2014 |
| These data indicate that MED28 regulates cellular migration in a MEK1-dependent manner in human breast cancer cells, reinforcing the important cellular roles of MED28. | MED28 regulates MEK1-dependent cellular migration in human breast cancer cells.
Huang CY, Chou YH, Hsieh NT, Chen HH, Lee MF. | 11/17/2012 |
| High MED28 is associated with breast cancer. | Elevated MED28 expression predicts poor outcome in women with breast cancer.
Yoon NK, Maresh EL, Elshimali Y, Li A, Horvath S, Seligson DB, Chia D, Goodglick L., Free PMC Article | 02/5/2011 |
| EG-1 has a role in breast tumor growth | Targeted inhibition of EG-1 blocks breast tumor growth.
Lu M, Sartippour MR, Zhang L, Norris AJ, Brooks MN. | 01/21/2010 |
| Study reports that down-regulation of human Med28 expression in NIH3T3 cells results in a significant induction of several genes associated with smooth muscle cell (SMC)differentiation; conversely, overexpression of MED28 represses SMC gene expression. | Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation.
Beyer KS, Beauchamp RL, Lee MF, Gusella JF, Näär AM, Ramesh V. | 01/21/2010 |
| demonstrate an interaction between Grb2 and magicin. In addition, merlin is capable of forming a ternary complex with magicin and Grb2 | Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2.
Wiederhold T, Lee MF, James M, Neujahr R, Smith N, Murthy A, Hartwig J, Gusella JF, Ramesh V. | 01/21/2010 |
| EG-1 is a positive stimulator of cellular proliferation, and may possibly be involved in signaling pathways involving Src and MAPK activation. | The novel gene EG-1 stimulates cellular proliferation.
Lu M, Zhang L, Maul RS, Sartippour MR, Norris A, Whitelegge J, Rao JY, Brooks MN. | 01/21/2010 |
| May serve as a multi-faceted adaptor/scaffold to relay cellular signaling to the cytoskeleton and from the cytoskeleton to the nucleus. | Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation.
Lee MF, Beauchamp RL, Beyer KS, Gusella JF, Ramesh V. | 01/21/2010 |
| EG-1 may be involved in signaling pathways including c-Src activation. | EG-1 interacts with c-Src and activates its signaling pathway.
Lu M, Zhang L, Sartippour MR, Norris AJ, Brooks MN. | 01/21/2010 |