| CEP63 upregulates YAP1 to promote colorectal cancer progression through stabilizing RNA binding protein FXR1. | CEP63 upregulates YAP1 to promote colorectal cancer progression through stabilizing RNA binding protein FXR1.
Ling H, Cao CH, Han K, Lv YR, Ma XD, Cao JH, Chen JW, Li S, Lin JL, Fang YJ, Pan ZZ, Xie D, Wang FW. | 10/8/2022 |
| Polymorphism in miRNA target sites of CEP-63 and CEP-152 ring complex influences expression of CEP genes and favors tumorigenesis in glioma. | Polymorphism in miRNA target sites of CEP-63 and CEP-152 ring complex influences expression of CEP genes and favors tumorigenesis in glioma.
Mahjabeen I, Maqsood Y, Abbasi R, Ahmed MW, Kayani MA. | 01/22/2022 |
| Cep63 knockout inhibits the malignant phenotypes of papillary thyroid cancer cell line TPC1. | Cep63 knockout inhibits the malignant phenotypes of papillary thyroid cancer cell line TPC‑1.
Liu C, Yu F, Ma R, Zhang L, Du G, Niu D, Yin D., Free PMC Article | 12/25/2021 |
| CCDC57 Cooperates with Microtubules and Microcephaly Protein CEP63 and Regulates Centriole Duplication and Mitotic Progression. | CCDC57 Cooperates with Microtubules and Microcephaly Protein CEP63 and Regulates Centriole Duplication and Mitotic Progression.
Gurkaslar HK, Culfa E, Arslanhan MD, Lince-Faria M, Firat-Karalar EN. | 05/22/2021 |
| [Study on Cep63 expression and apoptosis of thyroid papillary carcinoma cell lines TPC-1]. | [Study on Cep63 expression and apoptosis of thyroid papillary carcinoma cell lines TPC-1].
Liu CG, Yu FQ, Ma RS, Zhang LL, Wang MQ, Feng KX, Wang T, Yin DT. | 02/2/2021 |
| Requirement of the Cep57-Cep63 Interaction for Proper Cep152 Recruitment and Centriole Duplication. | Requirement of the Cep57-Cep63 Interaction for Proper Cep152 Recruitment and Centriole Duplication.
Wei Z, Kim TS, Ahn JI, Meng L, Chen Y, Ryu EK, Ku B, Zhou M, Kim SJ, Bang JK, van Deursen JM, Park JE, Lee KS., Free PMC Article | 08/15/2020 |
| Study shows that Cep63 and Cep152 cooperatively generate a heterotetrameric alpha-helical bundle that functions in conjunction with its neighboring hydrophobic motifs to self-assemble into a higher-order cylindrical architecture capable of recruiting downstream components, including Plk4, a key regulator for centriole duplication. Mutations disrupting the self-assembly abrogate Plk4-mediated centriole duplication. | Molecular architecture of a cylindrical self-assembly at human centrosomes.
Kim TS, Zhang L, Il Ahn J, Meng L, Chen Y, Lee E, Bang JK, Lim JM, Ghirlando R, Fan L, Wang YX, Kim BY, Park JE, Lee KS., Free PMC Article | 04/6/2019 |
| CEP63 is particularly important for brain development and might control the proliferation and migration of cells when those two events need to be highly coordinated. | Mutation in CEP63 co-segregating with developmental dyslexia in a Swedish family.
Einarsdottir E, Svensson I, Darki F, Peyrard-Janvid M, Lindvall JM, Ameur A, Jacobsson C, Klingberg T, Kere J, Matsson H., Free PMC Article | 04/16/2016 |
| centrosomal Cdk1 signals were strongly diminished in cells treated with Cep63 siRNA when sc-54 was used for Cdk1 labeling | Cep63 recruits cdk1 to the centrosome-letter.
Alsara M, Löffler H, Fechter A, Bartek J, Krämer A. | 04/18/2015 |
| both mouse and human Cep63 and Cep152 cooperate to ensure efficient centriole duplication by promoting the accumulation of essential centriole duplication factors upstream of SAS-6 recruitment and procentriole formation. | Cep63 and cep152 cooperate to ensure centriole duplication.
Brown NJ, Marjanović M, Lüders J, Stracker TH, Costanzo V., Free PMC Article | 04/5/2014 |
| Cep57, Cep63, and Cep152 are parts of a ring-like complex localizing around the proximal end of centrioles. | Selective chemical crosslinking reveals a Cep57-Cep63-Cep152 centrosomal complex.
Lukinavičius G, Lavogina D, Orpinell M, Umezawa K, Reymond L, Garin N, Gönczy P, Johnsson K. | 08/31/2013 |
| One new SNP (rs112926188) in CEP63O was reported. Analysis showed that rs112926188 allele substituting proline at the 61st residue position of CEP63 produced more flexibility in three-deimensional space. | Computational investigation of pathogenic nsSNPs in CEP63 protein.
Kumar A, Purohit R. | 08/18/2012 |
| Findings define Cep63 as a centrosomal recruitment factor for Cdk1 that is essential for mitotic entry, providing a physical link between the centrosome and the cell-cycle machinery. | Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance.
Löffler H, Fechter A, Matuszewska M, Saffrich R, Mistrik M, Marhold J, Hornung C, Westermann F, Bartek J, Krämer A. | 07/30/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesAssociation of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.
Lee JJ, Essers JB, Kugathasan S, Escher JC, Lettre G, Butler JL, Stephens MC, Ramoni MF, Grand RJ, Hirschhorn J. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
Zhao J, Li M, Bradfield JP, Zhang H, Mentch FD, Wang K, Sleiman PM, Kim CE, Glessner JT, Hou C, Keating BJ, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Chiavacci RM, Berkowitz RI, Hakonarson H, Grant SF. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966.
Sovio U, Bennett AJ, Millwood IY, Molitor J, O'Reilly PF, Timpson NJ, Kaakinen M, Laitinen J, Haukka J, Pillas D, Tzoulaki I, Molitor J, Hoggart C, Coin LJ, Whittaker J, Pouta A, Hartikainen AL, Freimer NB, Widen E, Peltonen L, Elliott P, McCarthy MI, Jarvelin MR. | 03/25/2009 |
| CEP63 transcripts exhibited three different expression patterns, downregulation was found in about 50% of the cases analyzed and CEP63 gene transcription was associated with invasive tumors. | The transcripts of SFRP1,CEP63 and EIF4G2 genes are frequently downregulated in transitional cell carcinomas of the bladder.
Buim ME, Soares FA, Sarkis AS, Nagai MA. | 01/21/2010 |