| Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1. | Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1.
D'Andrea L, Lucato CM, Marquez EA, Chang YG, Civciristov S, Mastos C, Lupton CJ, Huang C, Elmlund H, Schittenhelm RB, Mitchell CA, Whisstock JC, Halls ML, Ellisdon AM. | 01/22/2022 |
| Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein Facilitates Glioma Progression via Akt and Stat3 Signaling. | Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein Facilitates Glioma Progression via Akt and Stat3 Signaling.
Shang J, Li Y, Yin G, Li Z, Jiang L, Bai Q. | 01/8/2022 |
| PREX2 gene's expression in gastric antral epithelial cells of patients with H. pylori infection. | PREX2 gene's expression in gastric antral epithelial cells of patients with H. pylori infection.
Hedayati MA, Ahmadi S, Servatyari K, Sheikhesmaeili F. | 11/6/2021 |
| Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma. | Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma.
Yang MH, Yen CH, Chen YF, Fang CC, Li CH, Lee KJ, Lin YH, Weng CH, Liu TT, Huang SF, Teh BT, Chen YA., Free PMC Article | 09/19/2020 |
| MicroRNA-561 Affects Proliferation and Cell Cycle Transition Through PTEN/AKT Signaling Pathway by Targeting P-REX2a in NSCLC. | MicroRNA-561 Affects Proliferation and Cell Cycle Transition Through PTEN/AKT Signaling Pathway by Targeting P-REX2a in NSCLC.
Liao Z, Zheng Q, Wei T, Zhang Y, Ma J, Zhao Z, Sun H, Nan K., Free PMC Article | 09/19/2020 |
| CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction. | CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction.
Yeung YT, Fan S, Lu B, Yin S, Yang S, Nie W, Wang M, Zhou L, Li T, Li X, Bode AM, Dong Z., Free PMC Article | 08/22/2020 |
| Study demonstrates that miR-637 inhibites melanoma cell proliferation by activation of AKT signaling pathway and induces apoptosis through regulation of Bcl-2/Bax expression via targeting P-REX2a. | MiR-637 suppresses melanoma progression through directly targeting P-REX2a and inhibiting PTEN/AKT signaling pathway.
Zhang J, Liu WL, Zhang L, Ge R, He F, Gao TY, Tian Q, Mu X, Chen LH, Chen W, Li X. | 12/22/2018 |
| MiR-338-3p suppresses the TNF-alpha-induced lipogenesis in sebocytes by targeting PREX2a and down-regulating PI3K/AKT signaling. | MiR-338-3p inhibits TNF-α-induced lipogenesis in human sebocytes.
Liu J, Cao L, Feng Y, Li Y, Li T. | 04/14/2018 |
| Data suggest that PREX1 and PREX2 share similarities in amino acid sequence, domain structure, activation by PIP(3) [phosphatidylinositol 3,4,5-triphosphate] and G-protein-coupled receptors beta/gamma subunits; expression of PREX1 and PREX2 is altered in many cancers. [REVIEW] | P-Rex1 and P-Rex2 RacGEFs and cancer.
Srijakotre N, Man J, Ooms LM, Lucato CM, Ellisdon AM, Mitchell CA. | 12/30/2017 |
| complex signaling mechanisms that involve PREX2, PI3K/AKT/PTEN and downstream epigenetic machinery to deregulate expression of key cell cycle regulators | Interplay between PREX2 mutations and the PI3K pathway and its effect on epigenetic regulation of gene expression in NRAS-mutant melanoma.
Lissanu Deribe Y., Free PMC Article | 12/2/2017 |
| The rapid tumor onset observed in this replication attempt, compared to the original study, makes the detection of accelerated tumor growth in PREX2 expressing NRAS(G12D) melanocytes extremely difficult. | Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations.
Horrigan SK, Courville P, Sampey D, Zhou F, Cai S, Reproducibility Project: Cancer Biology., Free PMC Article | 11/25/2017 |
| PREX2 was identified as a frequently mutated gene in human melanoma. .. mutation of PREX2 can accelerate human melanoma growth. | Melanoma mystery.
Davis RJ., Free PMC Article | 11/25/2017 |
| Elevated PREX2 protein expression is associated with pathogenesis of hepatocellular carcinoma. | Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma.
Li CH, Yen CH, Chen YF, Lee KJ, Fang CC, Zhang X, Lai CC, Huang SF, Lin HK, Arthur Chen YM. | 05/13/2017 |
| findings identify PREX2 as a mediator of NRAS-mutant melanoma development that acts through the PI3K/PTEN/Akt pathway to regulate gene expression of a cell cycle regulator | Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.
Lissanu Deribe Y, Shi Y, Rai K, Nezi L, Amin SB, Wu CC, Akdemir KC, Mahdavi M, Peng Q, Chang QE, Hornigold K, Arold ST, Welch HC, Garraway LA, Chin L., Free PMC Article | 08/6/2016 |
| second messengers activate the Rac1 signal, which sets in motion a cascade whereby PAKs phosphorylate and negatively regulate PREX2 to decrease Rac1 activation. | p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase.
Barrows D, Schoenfeld SM, Hodakoski C, Silkov A, Honig B, Couvillon A, Shymanets A, Nürnberg B, Asara JM, Parsons R., Free PMC Article | 03/19/2016 |
| PREX2 mutants are likely selected in cancer to escape PTEN-mediated inhibition of invasion. | PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.
Mense SM, Barrows D, Hodakoski C, Steinbach N, Schoenfeld D, Su W, Hopkins BD, Su T, Fine B, Hibshoosh H, Parsons R., Free PMC Article | 01/2/2016 |
| CXCL9 is involved in the invasion ability of hepatocellular carcinoma cells possibly through up-regulation of its potential effector PREX2. | The effect of CXCL9 on the invasion ability of hepatocellular carcinoma through up-regulation of PREX2.
Lan X, Xiao F, Ding Q, Liu J, Liu J, Li J, Zhang J, Tian DA. | 07/25/2015 |
| Results demonstrate that miR-338-3p affects gastric cancer progression through PTEN-AKT signaling by targeting P-Rex2a in gastric cancer cells | miR-338-3p suppresses gastric cancer progression through a PTEN-AKT axis by targeting P-REX2a.
Guo B, Liu L, Yao J, Ma R, Chang D, Li Z, Song T, Huang C. | 01/17/2015 |
| P-REX2 PH-domain-mediated inhibition of PTEN has a role in regulating insulin sensitivity and glucose homeostasis | Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.
Hodakoski C, Hopkins BD, Barrows D, Mense SM, Keniry M, Anderson KE, Kern PA, Hawkins PT, Stephens LR, Parsons R., Free PMC Article | 03/15/2014 |
| MiR-338-3p affects the PTEN/Akt pathway by down-regulating PREX2a. | miR-338-3p suppresses neuroblastoma proliferation, invasion and migration through targeting PREX2a.
Chen X, Pan M, Han L, Lu H, Hao X, Dong Q. | 01/11/2014 |
| Studies indicate relevance of P-Rex1 and P-Rex2a, in breast tumorigenesis, and suggest that the exchange factors Vav2 and Vav3 play synergistic roles in breast cancer by sustaining tumor growth, neoangiogenesis, and metastasis. | Rho GEFs and cancer: linking gene expression and metastatic dissemination.
Barrio-Real L, Kazanietz MG. | 03/9/2013 |
| Analysis of whole-genome sequence data identified PREX2 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2)--a PTEN-interacting protein and negative regulator of PTEN in breast cancer--as a significantly mutated gene with a mutation frequency of approximately 14% in an independent extension cohort of 107 human melanomas | Melanoma genome sequencing reveals frequent PREX2 mutations.
Berger MF, Hodis E, Heffernan TP, Deribe YL, Lawrence MS, Protopopov A, Ivanova E, Watson IR, Nickerson E, Ghosh P, Zhang H, Zeid R, Ren X, Cibulskis K, Sivachenko AY, Wagle N, Sucker A, Sougnez C, Onofrio R, Ambrogio L, Auclair D, Fennell T, Carter SL, Drier Y, Stojanov P, Singer MA, Voet D, Jing R, Saksena G, Barretina J, Ramos AH, Pugh TJ, Stransky N, Parkin M, Winckler W, Mahan S, Ardlie K, Baldwin J, Wargo J, Schadendorf D, Meyerson M, Gabriel SB, Golub TR, Wagner SN, Lander ES, Getz G, Chin L, Garraway LA., Free PMC Article | 11/24/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| suggests that aberrant control of PTEN by P-REX2a may represent a key tumorigenic mechanism, in agreement with recent studies supporting the pathological relevance of several other proposed PTEN regulators | P-REX2a driving tumorigenesis by PTEN inhibition.
Leslie NR. | 01/21/2010 |
| identified P-REX2a as a PTEN-interacting protein; P-REX2a inhibited PTEN lipid phosphatase activity & stimulated the PI3K pathway only in the presence of PTEN; P-REX2a is a component of the PI3K pathway that can antagonize PTEN in cancer cells | Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a.
Fine B, Hodakoski C, Koujak S, Su T, Saal LH, Maurer M, Hopkins B, Keniry M, Sulis ML, Mense S, Hibshoosh H, Parsons R., Free PMC Article | 01/21/2010 |