| Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue. | Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue.
Ma Y, Dammer EB, Felsky D, Duong DM, Klein HU, White CC, Zhou M, Logsdon BA, McCabe C, Xu J, Wang M, Wingo TS, Lah JJ, Zhang B, Schneider J, Allen M, Wang X, Ertekin-Taner N, Seyfried NT, Levey AI, Bennett DA, De Jager PL., Free PMC Article | 01/8/2022 |
| Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels. | Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels.
Zhang X, Xin P, Yoast RE, Emrich SM, Johnson MT, Pathak T, Benson JC, Azimi I, Gill DL, Monteith GR, Trebak M., Free PMC Article | 08/7/2021 |
| ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly. | ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly.
Wu S, Chen M, Huang J, Zhang F, Lv Z, Jia Y, Cui YZ, Sun LZ, Wang Y, Tang Y, Verhoeft KR, Li Y, Qin Y, Lin X, Guan XY, Lam KO. | 05/15/2021 |
| ORAI2 Down-Regulation Potentiates SOCE and Decreases Abeta42 Accumulation in Human Neuroglioma Cells. | ORAI2 Down-Regulation Potentiates SOCE and Decreases Aβ42 Accumulation in Human Neuroglioma Cells.
Scremin E, Agostini M, Leparulo A, Pozzan T, Greotti E, Fasolato C., Free PMC Article | 02/20/2021 |
| Orai-1 and Orai-2 regulate oral cancer cell migration and colonisation by suppressing Akt/mTOR/NF-kappaB signalling. | Orai-1 and Orai-2 regulate oral cancer cell migration and colonisation by suppressing Akt/mTOR/NF-κB signalling.
Singh AK, Roy NK, Bordoloi D, Padmavathi G, Banik K, Khwairakpam AD, Kunnumakkara AB, Sukumar P. | 11/28/2020 |
| Higher expression of Orai2 was independently associated with a worse prognosis of patients with the classical and mesenchymal subtypes of glioblastoma.A strong association between Orai2 expression and apoptosis, stemness, and an epithelial-mesenchymal transition in the glioblastoma. | Identification of Key Pathways and Genes in the Orai2 Mediated Classical and Mesenchymal Subtype of Glioblastoma by Bioinformatic Analyses.
Yuan F, Yi L, Hai L, Wang Y, Yang Y, Li T, Tong L, Ma H, Liu P, Ming H, Ren B, Yu S, Lin Y, Yang X., Free PMC Article | 05/2/2020 |
| ORAI1-3, are preferentially expressed in proximal tubular epithelial cells and downregulated in patients with diabetic nephropathy. | ORAI channels are critical for receptor-mediated endocytosis of albumin.
Zeng B, Chen GL, Garcia-Vaz E, Bhandari S, Daskoulidou N, Berglund LM, Jiang H, Hallett T, Zhou LP, Huang L, Xu ZH, Nair V, Nelson RG, Ju W, Kretzler M, Atkin SL, Gomez MF, Xu SZ., Free PMC Article | 10/6/2018 |
| findings provide evidence for a role for Orai1 and Orai2, in SOCE and migration in the human HL60 promyeloblastic cell line | Orai1 and Orai2 mediate store-operated calcium entry that regulates HL60 cell migration and FAK phosphorylation.
Diez-Bello R, Jardin I, Salido GM, Rosado JA. | 09/9/2017 |
| results identified the ORAI-NOX2 feedback loop as a determinant of monocyte immune responses. | A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels.
Saul S, Gibhardt CS, Schmidt B, Lis A, Pasieka B, Conrad D, Jung P, Gaupp R, Wonnenberg B, Diler E, Stanisz H, Vogt T, Schwarz EC, Bischoff M, Herrmann M, Tschernig T, Kappl R, Rieger H, Niemeyer BA, Bogeski I. | 12/17/2016 |
| Orai1, Orai2 and STIM1 form functional Ca(2+) release-activated Ca(2+) channels in OUMS-27 cells (chondrocytes) and that these complexes are responsible for sustained Ca(2+) entry in response to agonist stimulation. | Orai1-Orai2 complex is involved in store-operated calcium entry in chondrocyte cell lines.
Inayama M, Suzuki Y, Yamada S, Kurita T, Yamamura H, Ohya S, Giles WR, Imaizumi Y. | 01/23/2016 |
| The higher amplitude of store-operated Ca2+ entry was associated to the over-expression for Stim2, Orai2-3, and TRPC1 while Stim2 levels remained constant and Stim1, Orai1, Orai3, TRPC1 and TRPC4 proteins were over-expressed in primary myelofibrosis. | Enhanced expression of Stim, Orai, and TRPC transcripts and proteins in endothelial progenitor cells isolated from patients with primary myelofibrosis.
Dragoni S, Laforenza U, Bonetti E, Reforgiato M, Poletto V, Lodola F, Bottino C, Guido D, Rappa A, Pareek S, Tomasello M, Guarrera MR, Cinelli MP, Aronica A, Guerra G, Barosi G, Tanzi F, Rosti V, Moccia F., Free PMC Article | 02/28/2015 |
| Orai1 but not Orai2 plays a major role in the influx of extracellular Ca2+ into and mediator release from HLMCs following their activation | The contribution of Orai(CRACM)1 and Orai(CRACM)2 channels in store-operated Ca2+ entry and mediator release in human lung mast cells.
Ashmole I, Duffy SM, Leyland ML, Bradding P., Free PMC Article | 07/5/2014 |
| Orai1 and Orai2 operate in a STIM-dependent manner, Orai3 does not interact with STIM isoforms upon calcium store depletion in platelets. | Capacitative and non-capacitative signaling complexes in human platelets.
Berna-Erro A, Galan C, Dionisio N, Gomez LJ, Salido GM, Rosado JA. | 02/23/2013 |
| With these data we show a new Ca(2)(+) entry pathway linked to the Ca(2)(+)/inositolphosphate second-messenger system in RPE cells which help to further understand regulatory pathways of agonists. | Expression of Orai genes and I(CRAC) activation in the human retinal pigment epithelium.
Cordeiro S, Strauss O. | 04/16/2011 |
| Data show that the fast Ca(2+)-dependent inactivation is mediated by three conserved glutamates in the C termini (CT) of Orai2 and Orai3, which show prominent fast Ca(2+)-dependent inactivation compared with Orai1. | Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels.
Lee KP, Yuan JP, Zeng W, So I, Worley PF, Muallem S., Free PMC Article | 01/21/2010 |
| analysis of activation of Orai1-3 channels by a STIM1 coiled-coil mutant | Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.
Frischauf I, Muik M, Derler I, Bergsmann J, Fahrner M, Schindl R, Groschner K, Romanin C., Free PMC Article | 01/21/2010 |
| The effects of 2-aminoethoxydiphenyl borate on orai1, orai2, orai3 metabolism in HEK293 cells with and without STIM1 are reported. | 2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels.
Peinelt C, Lis A, Beck A, Fleig A, Penner R., Free PMC Article | 01/21/2010 |
| Results suggest that Orai1, -2, and -3 channels are similarly inhibited by extracellular calcium, indicating similar affinities for Ca(2+) within the selectivity filter. | Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels.
DeHaven WI, Smyth JT, Boyles RR, Putney JW Jr. | 01/21/2010 |