| Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors. | Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors.
Sepehrimanesh M, Ding B., Free PMC Article | 12/19/2020 |
| LHX3 expression is significantly increased in carcinoma tissues, and associated with clinical stage and metastasis of patients. LHX3 expression is much higher in the advanced-stage patients than the early-stage patients, and is sharply increased in metastasic patients. | LHX3 is an advanced-stage prognostic biomarker and metastatic oncogene in hepatocellular carcinoma.
Huang B, Tian ZF, Li LF, Fan Y, Yin HY, Li Y, Mao Q, You ZL. | 03/28/2020 |
| Study did not identify HESX1 and LHX3 mutations by Sanger in brazilian patients with combined pituitary hormone deficiency | Molecular analysis of brazilian patients with combined pituitary hormone deficiency and orthotopic posterior pituitary lobe reveals eight different PROP1 alterations with three novel mutations.
Madeira JL, Nishi MY, Nakaguma M, Benedetti AF, Biscotto IP, Fernandes T, Pequeno T, Figueiredo T, Franca MM, Correa FA, Otto AP, Abrão M, Miras MB, Santos S, Jorge AA, Costalonga EF, Mendonca BB, Arnhold IJ, Carvalho LR. | 07/7/2018 |
| Further functional studies show that forced expression of LHX3 in lung cancer cells obviously promotes cell proliferation and invasion, whereas inhibits cell apoptosis. In summary, LHX3 is an early-stage and radiosensitivity prognostic biomarker, and a novel potential oncogene in lung adenocarcinoma . | LHX3 is an early stage and radiosensitivity prognostic biomarker in lung adenocarcinoma.
Lin X, Li Y, Wang J, Han F, Lu S, Wang Y, Luo W, Zhang M., Free PMC Article | 04/21/2018 |
| investigated the specific mutations in PROP1, POU1F1, LHX3, and HESX1 genes in patients with combined pituitary hormone deficiency (CPHD) in Turkey | Molecular analysis of PROP1, POU1F1, LHX3, and HESX1 in Turkish patients with combined pituitary hormone deficiency: a multicenter study.
Baş F, Uyguner ZO, Darendeliler F, Aycan Z, Çetinkaya E, Berberoğlu M, Şiklar Z, Öcal G, Darcan Ş, Gökşen D, Topaloğlu AK, Yüksel B, Özbek MN, Ercan O, Evliyaoğlu O, Çetinkaya S, Şen Y, Atabek E, Toksoy G, Aydin BK, Bundak R. | 05/28/2016 |
| LHX3 is upregulated in high-grade oligodendroglioma. | Lhx3 is required to maintain cancer cell development of high-grade oligodendroglioma.
Liu H, Liu W, Zhu B, Xu Q, Ni X, Yu J. | 08/22/2015 |
| The downstream enhancer region of LHX3 in regulating gene expression at the cellular level during development, is reported. | Cell-specific actions of a human LHX3 gene enhancer during pituitary and spinal cord development.
Park S, Mullen RD, Rhodes SJ., Free PMC Article | 08/9/2014 |
| Data suggest that low serum FSH (follicle stimulating hormone) levels in men with SNP in promoter region of FSHB (FSH beta subunit; -211G/T) result from reduced LHX3 binding to FSHB promoter and down-regulation of FSHB transcription in gonadotrophs. | A human FSHB promoter SNP associated with low FSH levels in men impairs LHX3 binding and basal FSHB transcription.
Benson CA, Kurz TL, Thackray VG., Free PMC Article | 11/16/2013 |
| The present study was unable to confirm a significant association of all of the three SNPs, rs12338076 in LHX3-QSOX2, and rs1457595 and rs17032362 in IGF1, with adult height in our study population. | Replication study of the association of SNPs in the LHX3-QSOX2 and IGF1 loci with adult height in the Japanese population; wide-ranging comparison of each SNP genotype distribution.
Fujihara J, Takeshita H, Kimura-Kataoka K, Yuasa I, Iida R, Ueki M, Nagao M, Kominato Y, Yasuda T. | 12/8/2012 |
| descriprion of pediatric patients with combined pituitary hormone deficiency with a novel mutation in LHX3; the T194R mutation affects a critical residue in the LHX3 protein; study extends understanding of phenotypic features, molecular mechanism and developmental course associated with mutations in the LHX3 gene | A recessive mutation resulting in a disabling amino acid substitution (T194R) in the LHX3 homeodomain causes combined pituitary hormone deficiency.
Bechtold-Dalla Pozza S, Hiedl S, Roeb J, Lohse P, Malik RE, Park S, Durán-Prado M, Rhodes SJ., Free PMC Article | 11/24/2012 |
| This study of the first nonconsanguineous patient with LHX3 mutations demonstrates the pleiotropic roles of LHX3 during development and its full involvement in the complex disease phenotype of syndromic combined pituitary hormone deficiency. | Symptomatic heterozygotes and prenatal diagnoses in a nonconsanguineous family with syndromic combined pituitary hormone deficiency resulting from two novel LHX3 mutations.
Sobrier ML, Brachet C, Vié-Luton MP, Perez C, Copin B, Legendre M, Heinrichs C, Amselem S. | 07/7/2012 |
| This study establishes ISL1 as a novel transcriptional regulator of LHX3 and describes a potential mechanism for regulation by PITX1. | A distal modular enhancer complex acts to control pituitary- and nervous system-specific expression of the LHX3 regulatory gene.
Mullen RD, Park S, Rhodes SJ., Free PMC Article | 05/26/2012 |
| LHX3 mutations are a rare cause of hypopituitarism. We report on a patient with a novel LHX3 mutation in exon 2 with the phenotype of combined pituitary hormone deficiency with short neck and sensorineural hearing impairment. [review] | A novel mutation of LHX3 is associated with combined pituitary hormone deficiency including ACTH deficiency, sensorineural hearing loss, and short neck-a case report and review of the literature.
Bonfig W, Krude H, Schmidt H. | 03/17/2012 |
| A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. | A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
Okada Y, Kamatani Y, Takahashi A, Matsuda K, Hosono N, Ohmiya H, Daigo Y, Yamamoto K, Kubo M, Nakamura Y, Kamatani N, Okada Y, Kamatani Y, Takahashi A, Matsuda K, Hosono N, Ohmiya H, Daigo Y, Yamamoto K, Kubo M, Nakamura Y, Kamatani N. | 09/27/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion.
Dateki S, Fukami M, Uematsu A, Kaji M, Iso M, Ono M, Mizota M, Yokoya S, Motomura K, Kinoshita E, Moriuchi H, Ogata T. | 06/30/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
Okada Y, Kamatani Y, Takahashi A, Matsuda K, Hosono N, Ohmiya H, Daigo Y, Yamamoto K, Kubo M, Nakamura Y, Kamatani N, Okada Y, Kamatani Y, Takahashi A, Matsuda K, Hosono N, Ohmiya H, Daigo Y, Yamamoto K, Kubo M, Nakamura Y, Kamatani N. | 04/7/2010 |
| Existence of cervical vertebral malformations are revealed, responsible for the rigid neck and the development of scoliosis in LIM3 mutated patients. | A novel mutation in the LIM homeobox 3 gene is responsible for combined pituitary hormone deficiency, hearing impairment, and vertebral malformations.
Kriström B, Zdunek AM, Rydh A, Jonsson H, Sehlin P, Escher SA. | 01/21/2010 |
| LHX3 mutations is associated with sensorineural hearing loss and interaction between LHX3 and SOX2 may contribute to the development of the inner ear and the anterior pituitary. | Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss.
Rajab A, Kelberman D, de Castro SC, Biebermann H, Shaikh H, Pearce K, Hall CM, Shaikh G, Gerrelli D, Grueters A, Krude H, Dattani MT. | 01/21/2010 |
| Although the LIM interaction domain of Ldb1 (Ldb1(LID)) and Isl1(LBD) share low levels of sequence homology, X-ray and NMR structures reveal that they bind Lhx3 in an identical manner, that is, Isl1(LBD) mimics Ldb1(LID). | Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes.
Bhati M, Lee C, Nancarrow AL, Lee M, Craig VJ, Bach I, Guss JM, Mackay JP, Matthews JM., Free PMC Article | 01/21/2010 |
| The presence of a hypointense pituitary lesion and other clinical findings broadens the phenotype associated with LHX3 gene mutation. | Clinical case seminar: a novel LHX3 mutation presenting as combined pituitary hormonal deficiency.
Bhangoo AP, Hunter CS, Savage JJ, Anhalt H, Pavlakis S, Walvoord EC, Ten S, Rhodes SJ. | 01/21/2010 |
| identified unique amino acids within LHX3 that are important for its transcriptional activity and are phosphorylated | Serine/threonine/tyrosine phosphorylation of the LHX3 LIM-homeodomain transcription factor.
Parker GE, West BE, Witzmann FA, Rhodes SJ. | 01/21/2010 |
| "Mutations in LHX3 are associated with a short neck combination with GHD (growth hormone deficiecy), PRL(prolactin) and TSH (thyroid stimulating hormone) and gonadotropin deficiency" p. 278 | Clinical characteristics and molecular analysis of PIT1, PROP1,LHX3, and HESX1 in combined pituitary hormone deficiency patients with abnormal pituitary MR imaging.
Kim SS, Kim Y, Shin YL, Kim GH, Kim TU, Yoo HW. | 01/21/2010 |
| Specificity protein 1 is a regulator of both promoters through interaction with GC boxes and also, a distal element within intron 1a that is recognized by nuclear factor I is critical for hLHX3b promoter function. | Two promoters mediate transcription from the human LHX3 gene: involvement of nuclear factor I and specificity protein 1.
Yaden BC, Garcia M 3rd, Smith TP, Rhodes SJ. | 01/21/2010 |
| LHX3 LIM homeodomain transcription factor is involved in activation of the FSH beta-subunit gene in the pituitary gonadotrope cell. | Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor.
West BE, Parker GE, Savage JJ, Kiratipranon P, Toomey KS, Beach LR, Colvin SC, Sloop KW, Rhodes SJ. | 01/21/2010 |
| LHX3 is expressed at all stages of early development. | Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development.
Sobrier ML, Attié-Bitach T, Netchine I, Encha-Razavi F, Vekemans M, Amselem S. | 01/21/2010 |