| Loss of ESRP2 Activates TAK1-MAPK Signaling through the Fetal RNA-Splicing Program to Promote Hepatocellular Carcinoma Progression. | Loss of ESRP2 Activates TAK1-MAPK Signaling through the Fetal RNA-Splicing Program to Promote Hepatocellular Carcinoma Progression.
Yan Q, Fang X, Liu X, Guo S, Chen S, Luo M, Lan P, Guan XY., Free PMC Article | 01/11/2024 |
| The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor. | The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor.
Legge D, Li L, Moriarty W, Lee D, Szemes M, Zahed A, Panousopoulos L, Chung WY, Aghabi Y, Barratt J, Williams R, Pritchard-Jones K, Malik KTA, Oltean S, Brown KW., Free PMC Article | 04/23/2022 |
| Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B. | Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B.
Becker T, Pich A, Tamm S, Hedtfeld S, Ibrahim M, Altmüller J, Dalibor N, Toliat MR, Janciauskiene S, Tümmler B, Stanke F., Free PMC Article | 05/15/2021 |
| Epithelial splicing regulatory protein 1 and 2 (ESRP1 and ESRP2) upregulation predicts poor prognosis in prostate cancer. | Epithelial splicing regulatory protein 1 and 2 (ESRP1 and ESRP2) upregulation predicts poor prognosis in prostate cancer.
Freytag M, Kluth M, Bady E, Hube-Magg C, Makrypidi-Fraune G, Heinzer H, Höflmayer D, Weidemann S, Uhlig R, Huland H, Graefen M, Bernreuther C, Wittmer C, Tsourlakis MC, Minner S, Dum D, Hinsch A, Luebke AM, Simon R, Sauter G, Schlomm T, Möller K., Free PMC Article | 05/1/2021 |
| Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis. | Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis.
Hyun J, Sun Z, Ahmadi AR, Bangru S, Chembazhi UV, Du K, Chen T, Tsukamoto H, Rusyn I, Kalsotra A, Diehl AM., Free PMC Article | 01/2/2021 |
| Here the authors find androgens regulate splicing through androgen receptor-mediated transcriptional control of the epithelial-specific splicing regulator ESRP2. Androgen stimulation induces splicing switches in many endogenous ESRP2-controlled mRNA isoforms, including splicing switches correlating with disease progression. | Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer.
Munkley J, Li L, Krishnan SRG, Hysenaj G, Scott E, Dalgliesh C, Oo HZ, Maia TM, Cheung K, Ehrmann I, Livermore KE, Zielinska H, Thompson O, Knight B, McCullagh P, McGrath J, Crundwell M, Harries LW, Daugaard M, Cockell S, Barbosa-Morais NL, Oltean S, Elliott DJ., Free PMC Article | 02/22/2020 |
| In conclusion, our findings suggested that IFNG-AS1 may function as an oncogene in pituitary adenoma by interacting with ESRP2. | Long-noncoding RNA IFNG-AS1 exerts oncogenic properties by interacting with epithelial splicing regulatory protein 2 (ESRP2) in pituitary adenomas.
Lu G, Duan J, Zhou D. | 12/22/2018 |
| Results showed that the expression patterns of these genes were indicative of the onset of EMT in in-vitro models, but not in tissue samples. However, the ratio between ESRP1 or ESRP2 and RBFOX2 significantly decreased during EMT and positively correlated with the EMT-specific phenotype in cell models. Low ESRP1/RBFOX2 ratio value was associated with a higher risk of metastasis in early breast cancer patients. | Splicing factor ratio as an index of epithelial-mesenchymal transition and tumor aggressiveness in breast cancer.
Fici P, Gallerani G, Morel AP, Mercatali L, Ibrahim T, Scarpi E, Amadori D, Puisieux A, Rigaud M, Fabbri F., Free PMC Article | 02/24/2018 |
| Results indicate a tumor-suppressive role of the ring finger protein 111 (Arkadia)-epithelial splicing regulatory protein 2 (ESRP2) axis in clear-cell renal cell carcinoma (ccRCC). | The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma.
Mizutani A, Koinuma D, Seimiya H, Miyazono K., Free PMC Article | 09/16/2017 |
| The molecular mechanisms by which ESRP1 and ESPR2 exert positive as well as negative effects on cancer progression have been summarized. (Review) | Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression.
Hayakawa A, Saitoh M, Miyazawa K. | 09/9/2017 |
| Findings define a direct role for ESRP2 in the generation of conserved repertoires of adult splice isoforms that facilitate terminal differentiation and maturation of hepatocytes. | ESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation.
Bhate A, Parker DJ, Bebee TW, Ahn J, Arif W, Rashan EH, Chorghade S, Chau A, Lee JH, Anakk S, Carstens RP, Xiao X, Kalsotra A., Free PMC Article | 05/14/2016 |
| ESRP1 and ESRP2 suppress cancer cell motility via different mechanisms. | Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms.
Ishii H, Saitoh M, Sakamoto K, Kondo T, Katoh R, Tanaka S, Motizuki M, Masuyama K, Miyazawa K., Free PMC Article | 12/20/2014 |
| functions of the ESRP2 in an epithelial posttranscriptional gene expression program. | Genome-wide determination of a broad ESRP-regulated posttranscriptional network by high-throughput sequencing.
Dittmar KA, Jiang P, Park JW, Amirikian K, Wan J, Shen S, Xing Y, Carstens RP., Free PMC Article | 06/30/2012 |
| ESRP2 coordinates a complex alternative splicing network that adds an important post-transcriptional layer to the changes in gene expression that underlie epithelial-mesenchymal transitions during development and disease. | An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition.
Warzecha CC, Jiang P, Amirikian K, Dittmar KA, Lu H, Shen S, Guo W, Xing Y, Carstens RP., Free PMC Article | 10/30/2010 |
| results further establish ESRP1 and ESRP2 as global regulators of an epithelial splicing regulatory network. | The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events.
Warzecha CC, Shen S, Xing Y, Carstens RP., Free PMC Article | 04/19/2010 |
| ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. | ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing.
Warzecha CC, Sato TK, Nabet B, Hogenesch JB, Carstens RP., Free PMC Article | 01/21/2010 |