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    JADE1 jade family PHD finger 1 [ Homo sapiens (human) ]

    Gene ID: 79960, updated on 10-Oct-2024

    GeneRIFs: Gene References Into Functions

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    GeneRIFPubMed TitleDate
    MicroRNA-155-5p Targets JADE-1, Promoting Proliferation, Migration, and Invasion in Clear Cell Renal Cell Carcinoma Cells.

    MicroRNA-155-5p Targets JADE-1, Promoting Proliferation, Migration, and Invasion in Clear Cell Renal Cell Carcinoma Cells.
    Kalantzakos T, Hooper K, Das S, Sullivan T, Canes D, Moinzadeh A, Rieger-Christ K., Free PMC Article

    		05/19/2023
    Genome-wide association study and functional validation implicates JADE1 in tauopathy.

    Genome-wide association study and functional validation implicates JADE1 in tauopathy.
    Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, Whitney K, Dangoor DK, Walsh H, Marcora E, Hefti MM, Casella A, Sissoko CT, Kapoor M, Novikova G, Udine E, Wong G, Tang W, Bhangale T, Hunkapiller J, Ayalon G, Graham RR, Cherry JD, Cortes EP, Borukov VY, McKee AC, Stein TD, Vonsattel JP, Teich AF, Gearing M, Glass J, Troncoso JC, Frosch MP, Hyman BT, Dickson DW, Murray ME, Attems J, Flanagan ME, Mao Q, Mesulam MM, Weintraub S, Woltjer RL, Pham T, Kofler J, Schneider JA, Yu L, Purohit DP, Haroutunian V, Hof PR, Gandy S, Sano M, Beach TG, Poon W, Kawas CH, Corrada MM, Rissman RA, Metcalf J, Shuldberg S, Salehi B, Nelson PT, Trojanowski JQ, Lee EB, Wolk DA, McMillan CT, Keene CD, Latimer CS, Montine TJ, Kovacs GG, Lutz MI, Fischer P, Perrin RJ, Cairns NJ, Franklin EE, Cohen HT, Raj T, Cobos I, Frost B, Goate A, White Iii CL, Crary JF., Free PMC Article

    		03/12/2022
    results indicate that the N-terminal region of JADE1 functions as a platform that brings together the catalytic HBO1 subunit with its cognate H3-H4 substrate for histone acetylation

    The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3-H4 substrate.
    Han J, Lachance C, Ricketts MD, McCullough CE, Gerace M, Black BE, Côté J, Marmorstein R., Free PMC Article

    		01/19/2019
    identification of SNPs within the IQCJ, NXPH1, PHF17 and MYB genes partly explaining the large interindividual variability observed in plasma triglyceride levels in response to an n-3 fatty acid supplementation

    Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation.
    Vallée Marcotte B, Cormier H, Guénard F, Rudkowska I, Lemieux S, Couture P, Vohl MC.

    		11/18/2017
    A genome-wide association study (GWAS) identified loci associated with the plasma triglyceride (TG) response to omega-3 fatty acid (FA) supplementation in IQCJ, NXPH1, PHF17 and MYB.

    Plasma Triglyceride Levels May Be Modulated by Gene Expression of IQCJ, NXPH1, PHF17 and MYB in Humans.
    Vallée Marcotte B, Guénard F, Cormier H, Lemieux S, Couture P, Rudkowska I, Vohl MC., Free PMC Article

    		04/29/2017
    JADE1 expression has a role in colon cancers, renal carcinomas, and in acute kidney injuries and regeneration. (Review)

    Structure, function and regulation of jade family PHD finger 1 (JADE1).
    Panchenko MV., Free PMC Article

    		01/28/2017
    Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis.

    Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.
    Borgal L, Rinschen MM, Dafinger C, Liebrecht VI, Abken H, Benzing T, Schermer B., Free PMC Article

    		01/14/2017
    JADE1S protein localized to centrosomes in interphase and mitotic cells, and to the midbody during cytokinesis.

    The novel function of JADE1S in cytokinesis of epithelial cells.
    Siriwardana NS, Meyer RD, Panchenko MV., Free PMC Article

    		06/28/2016
    Casein kinase 1 alpha specifically phosphorylates Jade-1 at an unprimed SLS phosphorylation site.

    Casein kinase 1 α phosphorylates the Wnt regulator Jade-1 and modulates its activity.
    Borgal L, Rinschen MM, Dafinger C, Hoff S, Reinert MJ, Lamkemeyer T, Lienkamp SS, Benzing T, Schermer B., Free PMC Article

    		02/7/2015
    Increase in the number of cells with cytoplasmic JADE1S correlated with activation of tubular cell proliferation and inversely correlated with the number of cells with nuclear JADE1S, supporting role of HBO1-JADE1 shuttling during organ regeneration.

    Cell cycle-dependent chromatin shuttling of HBO1-JADE1 histone acetyl transferase (HAT) complex.
    Siriwardana NS, Meyer R, Havasi A, Dominguez I, Panchenko MV., Free PMC Article

    		01/24/2015
    lncRNA-JADE is a key functional link that connects the DDR to histone H4 acetylation, and that dysregulation of lncRNA-JADE may contribute to breast tumorigenesis.

    A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation.
    Wan G, Hu X, Liu Y, Han C, Sood AK, Calin GA, Zhang X, Lu X., Free PMC Article

    		01/4/2014
    Reduced Jade-1 expression is associated with clear-cell renal cell carcinomas.

    Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma.
    Zeng L, Bai M, Mittal AK, El-Jouni W, Zhou J, Cohen DM, Zhou MI, Cohen HT., Free PMC Article

    		11/30/2013
    The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate beta-catenin signaling.

    The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling.
    Borgal L, Habbig S, Hatzold J, Liebau MC, Dafinger C, Sacarea I, Hammerschmidt M, Benzing T, Schermer B., Free PMC Article

    		10/20/2012
    RCC with a low expression of Jade-1 is associated with a poor outcome and decreased survival

    Expression and clinical significance of von Hippel-Lindau downstream genes: Jade-1 and β-catenin related to renal cell carcinoma.
    Lian X, Duan X, Wu X, Li C, Chen S, Wang S, Cai Y, Weng Z.

    		10/20/2012
    Jade-1/1L are crucial co-factors for HBO1-mediated histone H4 acetylation

    Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex.
    Foy RL, Song IY, Chitalia VC, Cohen HT, Saksouk N, Cayrou C, Vaziri C, Côté J, Panchenko MV., Free PMC Article

    		01/21/2010
    The pVHL tumour suppressor and the Wnt tumorigenesis pathway are therefore directly linked through Jade-1.

    Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL.
    Chitalia VC, Foy RL, Bachschmid MM, Zeng L, Panchenko MV, Zhou MI, Bharti A, Seldin DC, Lecker SH, Dominguez I, Cohen HT., Free PMC Article

    		01/21/2010
    Jade-1 is a novel candidate transcriptional co-activator associated with HAT activity and may play a key role in the pathogenesis of renal cancer and von Hippel-Lindau disease

    von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity.
    Panchenko MV, Zhou MI, Cohen HT.

    		01/21/2010
    Jade-1 protein is a novel candidate regulatory factor in Von Hippel Lindau-mediated renal tumor suppression

    The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1.
    Zhou MI, Wang H, Ross JJ, Kuzmin I, Xu C, Cohen HT.

    		01/21/2010
    Jade-1 may suppress renal cancer cell growth in part by increasing apoptosis.

    Jade-1, a candidate renal tumor suppressor that promotes apoptosis.
    Zhou MI, Foy RL, Chitalia VC, Zhao J, Panchenko MV, Wang H, Cohen HT., Free PMC Article

    		01/21/2010
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