| Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma progression through LIPC/AKT axis. | Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma progression through LIPC/AKT axis.
Deng R, Lu X, Hong C, Cai R, Wang P, Xiong L, Wang X, Chen Q, Lin J., Free PMC Article | 11/5/2022 |
| TUSC3 inhibits cell proliferation and invasion in cervical squamous cell carcinoma via suppression of the AKT signalling pathway. | TUSC3 inhibits cell proliferation and invasion in cervical squamous cell carcinoma via suppression of the AKT signalling pathway.
Sun F, Jie Q, Li Q, Wei Y, Li H, Yue X, Ma Y., Free PMC Article | 04/30/2022 |
| Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation. | Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation.
Ouidir M, Mendola P, Buck Louis GM, Kannan K, Zhang C, Tekola-Ayele F., Free PMC Article | 08/21/2021 |
| Tumour suppressor candidate 3 inhibits biological function and increases endoplasmic reticulum stress of melanoma cells WM451 by regulating AKT/GSK3-beta/beta-catenin pathway. | Tumour suppressor candidate 3 inhibits biological function and increases endoplasmic reticulum stress of melanoma cells WM451 by regulating AKT/GSK3-β/β-catenin pathway.
Wang S, Zhu W. | 05/22/2021 |
| TUSC3 induces drug resistance and cellular stemness via Hedgehog signaling pathway in colorectal cancer. | TUSC3 induces drug resistance and cellular stemness via Hedgehog signaling pathway in colorectal cancer.
Ren Y, Deng R, Cai R, Lu X, Luo Y, Wang Z, Zhu Y, Yin M, Ding Y, Lin J. | 05/22/2021 |
| UHRF1-KAT7-mediated regulation of TUSC3 expression via histone methylation/acetylation is critical for the proliferation of colon cancer cells. | UHRF1-KAT7-mediated regulation of TUSC3 expression via histone methylation/acetylation is critical for the proliferation of colon cancer cells.
Taniue K, Hayashi T, Kamoshida Y, Kurimoto A, Takeda Y, Negishi L, Iwasaki K, Kawamura Y, Goshima N, Akiyama T. | 11/28/2020 |
| TUSC3 accelerates cancer growth and induces the epithelial-mesenchymal transition in non-small-cell lung cancer cells by upregulating claudin-1. | TUSC3 accelerates cancer growth and induces epithelial-mesenchymal transition by upregulating claudin-1 in non-small-cell lung cancer cells.
Feng S, Zhai J, Lu D, Lin J, Dong X, Liu X, Wu H, Roden AC, Brandi G, Tavolari S, Bille A, Cai K. | 09/28/2019 |
| miR-UL112-3p exerts its oncogene function by directly targeting TUSC3 in Glioblastoma. | HCMV-encoded miR-UL112-3p promotes glioblastoma progression via tumour suppressor candidate 3.
Liang Q, Wang K, Wang B, Cai Q., Free PMC Article | 12/22/2018 |
| study demonstrated an oncogenic role of TUSC3 in Non-small cell lung cancer and showed that dis-regulation of TUSC3 may affect tumour cell invasion and migration through possible involvement in the Hedgehog (Hh) signalling pathway. | Oncogenic function of TUSC3 in non-small cell lung cancer is associated with Hedgehog signalling pathway.
Gu Y, Pei X, Ren Y, Cai K, Guo K, Chen J, Qin W, Lin M, Wang Q, Tang N, Cheng Z, Ding Y, Lin J. | 12/1/2018 |
| TUSC3 may act as an oncogene in the progression of colorectal cancer. | Expression of TUSC3 and its prognostic significance in colorectal cancer.
Zhu YF, Dong M. | 11/17/2018 |
| TUSC3 can function both as an oncogene and as a tumor suppressor. (Review) | TUSC3: functional duality of a cancer gene.
Vašíčková K, Horak P, Vaňhara P., Free PMC Article | 11/3/2018 |
| our data indicate that miR-132 induces temozolomide resistance and promotes the formation of cancer stem cell phenotypes by targeting TUSC3 in glioblastoma. | MicroRNA-132 induces temozolomide resistance and promotes the formation of cancer stem cell phenotypes by targeting tumor suppressor candidate 3 in glioblastoma.
Cheng ZX, Yin WB, Wang ZY., Free PMC Article | 06/2/2018 |
| This paper supports the previous clinical descriptions of the condition caused by TUSC3 mutations and describes the seventh family with mutations in this gene, thus contributing to the genetic spectrum of mutations. This is the first report of a family from the Arabian peninsula with this form of Intellectual disability . | Homozygous single base deletion in TUSC3 causes intellectual disability with developmental delay in an Omani family.
Al-Amri A, Saegh AA, Al-Mamari W, El-Asrag ME, Ivorra JL, Cardno AG, Inglehearn CF, Clapcote SJ, Ali M. | 10/28/2017 |
| SOX2 regulates the proliferation, migration and invasiveness of breast cancer cells through miR-181a-5p and miR-30e-5p which modulate TUSC3 protein levels | SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis.
Liu K, Xie F, Gao A, Zhang R, Zhang L, Xiao Z, Hu Q, Huang W, Huang Q, Lin B, Zhu J, Wang H, Que J, Lan X., Free PMC Article | 07/29/2017 |
| Decreased Tumor Suppressor Candidate 3 Predicts Poor Prognosis of Patients with Esophageal Squamous Cell Carcinoma | Decreased Tumor Suppressor Candidate 3 Predicts Poor Prognosis of Patients with Esophageal Squamous Cell Carcinoma.
Yu X, Zhang J, Zhong H, Liu F, Liang N, Wang Y, Meng X, Du J., Free PMC Article | 03/25/2017 |
| TUSC3 regulates proliferation and invasion of glioblastoma cells by inhibiting the activity of the Akt signaling pathway. | TUSC3 suppresses glioblastoma development by inhibiting Akt signaling.
Jiang Z, Guo M, Zhang X, Yao L, Shen J, Ma G, Liu L, Zhao L, Xie C, Liang H, Wang H, Zhu M, Hu L, Song Y, Shen H, Lin Z. | 02/18/2017 |
| decreased immunological TUSC3 staining is a factor prognostic of poor survival in pancreatic cancer patients. | Decreased TUSC3 Promotes Pancreatic Cancer Proliferation, Invasion and Metastasis.
Fan X, Zhang X, Shen J, Zhao H, Yu X, Chen Y, Zhuang Z, Deng X, Feng H, Wang Y, Peng L., Free PMC Article | 07/16/2016 |
| The TUSC3 gene is associated with mental retardation in the Qinba mountain area in China; the sixth exon of the TUSC3 gene may contribute to the risk of developing the disease. | Association of TUSC3 gene polymorphisms with non-syndromic mental retardation based on nuclear families in the Qinba mountain area of China.
Zhang MJ, Xing LX, Cui M, Yang X, Shi JG, Li J, Zhang KJ, Zheng ZJ, Zhang FC, Li JL, Gao XC. | 03/26/2016 |
| Report frequencies of short tandem repeat markers linked to TUSC3 (MRT7) or NSUN2 (MRT5) genes used for homozygosity mapping of recessive intellectual disability. | Frequencies of Six (Five Novel) STR Markers Linked to TUSC3 (MRT7) or NSUN2 (MRT5) Genes Used for Homozygosity Mapping of Recessive Intellectual Disability.
Ghadami S, Mohammadi HM, Malbin J, Masoodifard M, Sarhaddi AB, Tavakkoly-Bazzaz J, Zeinali S. | 10/31/2015 |
| TUSC3 loss alters the ER stress response and accelerates prostate cancer growth in vivo | TUSC3 loss alters the ER stress response and accelerates prostate cancer growth in vivo.
Horak P, Tomasich E, Vaňhara P, Kratochvílová K, Anees M, Marhold M, Lemberger CE, Gerschpacher M, Horvat R, Sibilia M, Pils D, Krainer M., Free PMC Article | 10/24/2015 |
| Loss of TUSC3 alters the molecular response to endoplasmic reticulum stress. | Tumor suppressor candidate 3 (TUSC3) prevents the epithelial-to-mesenchymal transition and inhibits tumor growth by modulating the endoplasmic reticulum stress response in ovarian cancer cells.
Kratochvílová K, Horak P, Ešner M, Souček K, Pils D, Anees M, Tomasich E, Dráfi F, Jurtíková V, Hampl A, Krainer M, Vaňhara P. | 10/3/2015 |
| IGFII and N33 methylation status may be related to gastric carcinogenesis. | Methylation status of blood leukocyte DNA and risk of gastric cancer in a high-risk Chinese population.
Zhang Y, Su HJ, Pan KF, Zhang L, Ma JL, Shen L, Li JY, Liu WD, Oze I, Matsuo K, Yuasa Y, You WC. | 08/1/2015 |
| TUSC3 increases glycosylation efficiency for a subset of human glycoproteins by slowing glycoprotein folding. | Structural basis of substrate specificity of human oligosaccharyl transferase subunit N33/Tusc3 and its role in regulating protein N-glycosylation.
Mohorko E, Owen RL, Malojčić G, Brozzo MS, Aebi M, Glockshuber R. | 11/29/2014 |
| Homozygous deletion in TUSC3 causes syndromic intellectual disability. | Homozygous deletion in TUSC3 causing syndromic intellectual disability: a new patient.
Loddo S, Parisi V, Doccini V, Filippi T, Bernardini L, Brovedani P, Ricci F, Novelli A, Battaglia A. | 10/19/2013 |
| TUSC3 is a tumor suppressor gene in ovarian cancer. | Loss of the oligosaccharyl transferase subunit TUSC3 promotes proliferation and migration of ovarian cancer cells.
Vaňhara P, Horak P, Pils D, Anees M, Petz M, Gregor W, Zeillinger R, Krainer M. | 08/31/2013 |