| FAK mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation by modulating mitochondrial transcription termination factor 1/cyclin D1. | FAK mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation by modulating mitochondrial transcription termination factor 1/cyclin D1.
Lin C, Yang H, Luo Q, Liu Q., Free PMC Article | 03/19/2024 |
| MTERF1 has the ability to accommodate alternate active conformations. | Base Flipping by MTERF1 Can Accommodate Multiple Conformations and Occurs in a Stepwise Fashion.
Byrnes J, Hauser K, Norona L, Mejia E, Simmerling C, Garcia-Diaz M., Free PMC Article | 06/24/2017 |
| It has been demonstrated that MTERF1 arrests mitochondrial DNA (mtDNA) replication with distinct polarity whereby MTERF1 acts as a directional contra-helicase, blocking mtDNA unwinding by the mitochondrial helicase TWINKLE. | Mitochondrial transcription termination factor 1 directs polar replication fork pausing.
Shi Y, Posse V, Zhu X, Hyvärinen AK, Jacobs HT, Falkenberg M, Gustafsson CM., Free PMC Article | 06/10/2017 |
| Studies indicate that the structure of the mitochondrial transcription termination factor (MTERF1) provides insight into the mechanism of binding, recognition of the termination sequence and the conformational changes involved in mediating termination. | Mitochondrial transcription: how does it end?
Byrnes J, Garcia-Diaz M., Free PMC Article | 06/23/2012 |
| Single nucleotide polymorphism in MTERF gene is associated with epithelial ovarian cancer. | Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk.
Permuth-Wey J, Chen YA, Tsai YY, Chen Z, Qu X, Lancaster JM, Stockwell H, Dagne G, Iversen E, Risch H, Barnholtz-Sloan J, Cunningham JM, Vierkant RA, Fridley BL, Sutphen R, McLaughlin J, Narod SA, Goode EL, Schildkraut JM, Fenstermacher D, Phelan CM, Sellers TA., Free PMC Article | 10/1/2011 |
| data suggested that hMTERF4 is an essential factor for cell proliferation, which is probably modulated by mitochondrial transcription to promote cell proliferation | hMTERF4 knockdown in HeLa cells results in sub-G1 cell accumulation and cell death.
Yu M, Dai J, Huang W, Jiao Y, Liu L, Wu M, Tan D. | 08/27/2011 |
| Data show that mTERF protein levels materially affect the amount of readthrough transcription on the antisense strand of mtDNA, whilst the effects on sense-strand transcripts are complex, and suggest the influence of compensatory mechanisms. | Effects on mitochondrial transcription of manipulating mTERF protein levels in cultured human HEK293 cells.
Hyvärinen AK, Kumanto MK, Marjavaara SK, Jacobs HT., Free PMC Article | 01/1/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| Presented are the crystal structures of human mitochondrial regulator MTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(Leu)(UUR) gene sequence. | Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat.
Jiménez-Menéndez N, Fernández-Millán P, Rubio-Cosials A, Arnan C, Montoya J, Jacobs HT, Bernadó P, Coll M, Usón I, Solà M. | 08/2/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The structure indicates that upon sequence recognition MTERF1 unwinds the DNA molecule, promoting eversion of three nucleotides. | Helix unwinding and base flipping enable human MTERF1 to terminate mitochondrial transcription.
Yakubovskaya E, Mejia E, Byrnes J, Hambardjieva E, Garcia-Diaz M., Free PMC Article | 06/28/2010 |
| mTERF mRNA levels were higher in elite athletes compared with moderately active subjects | Training response of mitochondrial transcription factors in human skeletal muscle.
Norrbom J, Wallman SE, Gustafsson T, Rundqvist H, Jansson E, Sundberg CJ. | 03/8/2010 |
| analysis of DNA light-strand preferential recognition of human mitochondria transcription termination factor mTERF | DNA light-strand preferential recognition of human mitochondria transcription termination factor mTERF.
Nam SC, Kang C. | 01/21/2010 |
| Results indicate a role for mTERF in mtDNA replication, in addition to its role in transcription. | The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA.
Hyvärinen AK, Pohjoismäki JL, Reyes A, Wanrooij S, Yasukawa T, Karhunen PJ, Spelbrink JN, Holt IJ, Jacobs HT., Free PMC Article | 01/21/2010 |
| mTERF exists in mitochondria in two forms, an active monomer and an inactive large size complex | A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity.
Asin-Cayuela J, Helm M, Attardi G. | 01/21/2010 |
| monomeric human mTERF is fully active in its non-phosphorylated form and that the protein does not require additional cellular factors to terminate mitochondrial transcription in vitro | The human mitochondrial transcription termination factor (mTERF) is fully active in vitro in the non-phosphorylated form.
Asin-Cayuela J, Schwend T, Farge G, Gustafsson CM. | 01/21/2010 |