| SNIP1 reduces extracellular matrix degradation and inflammation via inhibiting the NF-kappaB signaling pathway in osteoarthritis. | SNIP1 reduces extracellular matrix degradation and inflammation via inhibiting the NF-κB signaling pathway in osteoarthritis.
Chen Y, Guo W, Lu W, Guo X, Gao W, Yin Z. | 10/13/2023 |
| MKRN1 promotes colorectal cancer metastasis by activating the TGF-beta signalling pathway through SNIP1 protein degradation. | MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation.
Zhang Y, Li QS, Liu HL, Tang HT, Yang HL, Wu DQ, Huang YY, Li LC, Liu LH, Li MX., Free PMC Article | 09/1/2023 |
| MiR-138-5p suppresses the progression of lung cancer by targeting SNIP1. | MiR-138-5p suppresses the progression of lung cancer by targeting SNIP1.
Wu J, Han X, Yang X, Li Y, Liang Y, Sun G, Wang R, Wang P, Xie S, Feng J, Sun H., Free PMC Article | 03/1/2023 |
| KMT5A-methylated SNIP1 promotes triple-negative breast cancer metastasis by activating YAP signaling. | KMT5A-methylated SNIP1 promotes triple-negative breast cancer metastasis by activating YAP signaling.
Yu B, Su J, Shi Q, Liu Q, Ma J, Ru G, Zhang L, Zhang J, Hu X, Tang J., Free PMC Article | 07/23/2022 |
| MiR-223 promotes pyroptosis of enteritis cells through activating NF-kappaB signalling pathway by targeting SNIP1 in inflammatory bowel disease. | MiR-223 promotes pyroptosis of enteritis cells through activating NF-κB signalling pathway by targeting SNIP1 in inflammatory bowel disease.
Zhang LZ, Xue H, Qiao CX, You WL, Di AT, Zhao G. | 04/2/2022 |
| Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc. | Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc.
Zhong Y, Yang L, Xiong F, He Y, Tang Y, Shi L, Fan S, Li Z, Zhang S, Gong Z, Guo C, Liao Q, Zhou Y, Zhou M, Xiang B, Li X, Li Y, Zeng Z, Li G, Xiong W., Free PMC Article | 03/12/2022 |
| A biallelic SNIP1 Amish founder variant causes a recognizable neurodevelopmental disorder. | A biallelic SNIP1 Amish founder variant causes a recognizable neurodevelopmental disorder.
Ammous Z, Rawlins LE, Jones H, Leslie JS, Wenger O, Scott E, Deline J, Herr T, Evans R, Scheid A, Kennedy J, Chioza BA, Ames RM, Cross HE, Puffenberger EG, Harries L, Baple EL, Crosby AH., Free PMC Article | 12/4/2021 |
| This study also reveals a TET2-SNIP1-c-MYC pathway in mediating DNA damage response. | SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.
Chen LL, Lin HP, Zhou WJ, He CX, Zhang ZY, Cheng ZL, Song JB, Liu P, Chen XY, Xia YK, Chen XF, Sun RQ, Zhang JY, Sun YP, Song L, Liu BJ, Du RK, Ding C, Lan F, Huang SL, Zhou F, Liu S, Xiong Y, Ye D, Guan KL., Free PMC Article | 12/14/2019 |
| Overexpression of miR-335 inhibits the migration and invasion of osteosarcoma by targeting SNIP1 | Overexpression of miR-335 inhibits the migration and invasion of osteosarcoma by targeting SNIP1.
Xie Y, Deng H, Wei R, Sun W, Qi Y, Yao S, Cai L, Wang Y, Deng Z. | 11/23/2019 |
| these data demonstrated a novel mechanism whereby SNIP1 regulates intestinal inflammation through modulating intestinal epithelial barrier function | Smad nuclear interacting protein 1 (SNIP1) inhibits intestinal inflammation through regulation of epithelial barrier function.
Shi Y, He C, Ma C, Yu T, Cong Y, Cai W, Liu Z. | 12/22/2018 |
| SUMOylation of SNIP1 leads to the loss of SNIP1-mediated inhibition on expression of the TGF-beta target genes PAI-1 and MMP2 and eventually enhances TGF-beta-regulated cell migration and invasion. | SUMO Modification Reverses Inhibitory Effects of Smad Nuclear Interacting Protein-1 in TGF-β Responses.
Liu S, Long J, Yuan B, Zheng M, Xiao M, Xu J, Lin X, Feng XH., Free PMC Article | 05/27/2017 |
| Involvement of SNIP1 in progression of lung cancer by regulating the RB/HDAC1 interaction. | High expression of SNIP1 correlates with poor prognosis in non-small cell lung cancer and SNIP1 interferes with the recruitment of HDAC1 to RB in vitro.
Jeon HS, Choi YY, Fukuoka J, Fujii M, Lyakh LA, Song SH, Travis WD, Park JY, Jen J. | 04/19/2014 |
| SNIP1 in cells strongly activated the heat shock element signaling pathway, and SNIP1 might selectively regulate the transcription of some heat shock proteins through associating with heat shock elements | SNIP1: a new activator of HSE signaling pathway.
Li Q, An J, Liu X, Zhang M, Ling Y, Wang C, Zhao J, Yu L. | 09/1/2012 |
| Study identified sequence variants in the known disease-causing genes SLC6A3 and FLVCR1, and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6, BRAT1, SNIP1, CRADD, and HARS. | Genetic mapping and exome sequencing identify variants associated with five novel diseases.
Puffenberger EG, Jinks RN, Sougnez C, Cibulskis K, Willert RA, Achilly NP, Cassidy RP, Fiorentini CJ, Heiken KF, Lawrence JJ, Mahoney MH, Miller CJ, Nair DT, Politi KA, Worcester KN, Setton RA, Dipiazza R, Sherman EA, Eastman JT, Francklyn C, Robey-Bond S, Rider NL, Gabriel S, Morton DH, Strauss KA., Free PMC Article | 07/14/2012 |
| overexpression of HIF-1alpha, TWIST2 or SNIP1 correlated with poor disease-free survival in patients with tongue squamous cell carcinoma | Hypoxia-inducible factor-1 alpha, in association with TWIST2 and SNIP1, is a critical prognostic factor in patients with tongue squamous cell carcinoma.
Liang X, Zheng M, Jiang J, Zhu G, Yang J, Tang Y. | 07/2/2011 |
| Study shows a novel mechanism regulating Cyclin D1 expression and offers new insight into the role of SNIP1 and associated proteins as regulators of proliferation and cancer. | Regulation of cyclin D1 RNA stability by SNIP1.
Bracken CP, Wall SJ, Barré B, Panov KI, Ajuh PM, Perkins ND., Free PMC Article | 01/21/2010 |
| SNIP1, the human homolog of DDL, is involved in miRNA biogenesis and interacts with Drosha | The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis.
Yu B, Bi L, Zheng B, Ji L, Chevalier D, Agarwal M, Ramachandran V, Li W, Lagrange T, Walker JC, Chen X., Free PMC Article | 01/21/2010 |
| Smad-binding peptide aptamers can be developed to selectively inhibit TGF-beta-induced gene expression. | Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP.
Cui Q, Lim SK, Zhao B, Hoffmann FM. | 01/21/2010 |
| define both a new function for SNIP1 and identify a previously unrecognized regulator of the cell cycle and cyclin D1 expression | The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression.
Roche KC, Wiechens N, Owen-Hughes T, Perkins ND. | 01/21/2010 |
| SNIP1 functions as a regulator of c-Myc activity, binding the N c-Myc N terminus through its C terminus, and that SNIP1 enhances the transcriptional activity of c-Myc by stabilizing it against proteosomal degradation and bridging the c-Myc/p300 complex. | SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes.
Fujii M, Lyakh LA, Bracken CP, Fukuoka J, Hayakawa M, Tsukiyama T, Soll SJ, Harris M, Rocha S, Roche KC, Tominaga SI, Jen J, Perkins ND, Lechleider RJ, Roberts AB. | 01/21/2010 |