| TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta. | TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta.
Miki R, Matsuo S, Ushida T, Tano S, Imai K, Nawa A, Kajiyama H, Kotani T. | 06/21/2024 |
| ENO1 promotes trophoblast invasion regulated by E2F8 in recurrent miscarriage. | ENO1 promotes trophoblast invasion regulated by E2F8 in recurrent miscarriage.
Liu Z, Wang C, Tang Y, Zhang X, Pei J, Liu H, Yu Y, Gu W. | 05/17/2024 |
| E2F8 exerts cancer-promoting effects by transcriptionally activating RRM2 and E2F8 knockdown synergizes with WEE1 inhibition in suppressing lung adenocarcinoma. | E2F8 exerts cancer-promoting effects by transcriptionally activating RRM2 and E2F8 knockdown synergizes with WEE1 inhibition in suppressing lung adenocarcinoma.
Liu K, Wang L, Lou Z, Guo L, Xu Y, Qi H, Fang Z, Mei L, Chen X, Zhang X, Shao J, Xiang X. | 12/6/2023 |
| Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK-dependent manner. | Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner.
Lee DY, Lee S, Kim YS, Park S, Bae SM, Cho EA, Park EJ, Park HH, Kim SY, So I, Chun JN, Jeon JH., Free PMC Article | 11/7/2023 |
| E2F8 knockdown suppresses cell proliferation and induces cell cycle arrest via Wnt/beta-Catenin pathway in ovarian cancer. | E2F8 knockdown suppresses cell proliferation and induces cell cycle arrest via Wnt/β-Catenin pathway in ovarian cancer.
Zhang M, Xu Y, Zhang Y, Lou G. | 11/6/2023 |
| Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation. | Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.
Park SA, Lim YJ, Ku WL, Zhang D, Cui K, Tang LY, Chia C, Zanvit P, Chen Z, Jin W, Wang D, Xu J, Liu O, Wang F, Cain A, Guo N, Nakatsukasa H, Wu C, Zhang YE, Zhao K, Chen W., Free PMC Article | 10/22/2022 |
| Cell cycle oscillators underlying orderly proteolysis of E2F8. | Cell cycle oscillators underlying orderly proteolysis of E2F8.
Wasserman D, Nachum S, Cohen M, Enrico TP, Noach-Hirsh M, Parasol J, Zomer-Polak S, Auerbach N, Sheinberger-Chorni E, Nevenzal H, Levi-Dadon N, Wang X, Lahmi R, Michaely E, Gerber D, Emanuele MJ, Tzur A., Free PMC Article | 06/5/2021 |
| E2F transcription factor 8 promotes proliferation and radioresistance in glioblastoma. | E2F transcription factor 8 promotes proliferation and radioresistance in glioblastoma.
Yu H, Zhang D, Li Z, Wang M. | 05/15/2021 |
| Carcinogenesis effects of E2F transcription factor 8 (E2F8) in hepatocellular carcinoma outcomes: an integrated bioinformatic report. | Carcinogenesis effects of E2F transcription factor 8 (E2F8) in hepatocellular carcinoma outcomes: an integrated bioinformatic report.
Lü Y, Zhang J, Li L, Li S, Yang Z., Free PMC Article | 03/20/2021 |
| E2F8 Induces Cell Proliferation and Invasion through the Epithelial-Mesenchymal Transition and Notch Signaling Pathways in Ovarian Cancer. | E2F8 Induces Cell Proliferation and Invasion through the Epithelial-Mesenchymal Transition and Notch Signaling Pathways in Ovarian Cancer.
Eoh KJ, Kim HJ, Lee JW, Kim LK, Park SA, Kim HS, Kim YT, Koo PJ., Free PMC Article | 02/20/2021 |
| E2F8 regulates the proliferation and invasion through epithelial-mesenchymal transition in cervical cancer. | E2F8 regulates the proliferation and invasion through epithelial-mesenchymal transition in cervical cancer.
Kim LK, Park SA, Eoh KJ, Heo TH, Kim YT, Kim HJ., Free PMC Article | 11/21/2020 |
| These results demonstrate that E2F8 modulates the growth of human colon cancer cells through promoting the NF-kappaB pathway. | Knockdown of E2F8 Suppresses Cell Proliferation in Colon Cancer Cells by Modulating the NF-κB Pathway.
Yan PY, Zhang XA. | 01/25/2020 |
| NONO post-transcriptionally regulates the expression of cell proliferation-related genes by binding to their mRNAs, as exemplified by S-phase-associated kinase 2 and E2F transcription factor 8. | RNA-binding protein NONO promotes breast cancer proliferation by post-transcriptional regulation of SKP2 and E2F8.
Iino K, Mitobe Y, Ikeda K, Takayama KI, Suzuki T, Kawabata H, Suzuki Y, Horie-Inoue K, Inoue S., Free PMC Article | 01/18/2020 |
| Authors detected the expression of hsa_circ_0002468, miR-561, and E2F8 by using quantitative real-time polymerase chain reaction (qRT-PCR) analyses. | Hsa_circ_0002468 Regulates the Neuronal Differentiation of SH-SY5Y Cells by Modulating the MiR-561/E2F8 Axis.
Yang M, Xiang G, Yu D, Yang G, He W, Yang S, Zhou G, Liu A., Free PMC Article | 10/5/2019 |
| miR-223-5p suppressed NSCLC progression through targeting E2F8. | miR-223-5p Suppresses Tumor Growth and Metastasis in Non-Small Cell Lung Cancer by Targeting E2F8.
Dou L, Han K, Xiao M, Lv F., Free PMC Article | 02/23/2019 |
| MiR-1258 may function as a suppressive factor by negatively controlling E2F8 | Upregulated miR-1258 regulates cell cycle and inhibits cell proliferation by directly targeting E2F8 in CRC.
Zhang Z, Li J, Huang Y, Peng W, Qian W, Gu J, Wang Q, Hu T, Ji D, Ji B, Zhang Y, Wang S, Sun Y., Free PMC Article | 12/22/2018 |
| High E2F8 expression is associated with breast cancer. | Upregulation of E2F8 promotes cell proliferation and tumorigenicity in breast cancer by modulating G1/S phase transition.
Ye L, Guo L, He Z, Wang X, Lin C, Zhang X, Wu S, Bao Y, Yang Q, Song L, Lin H., Free PMC Article | 02/10/2018 |
| E2F8 can shorten cisplatin induced G2/M arrest by promoting MASTL mediated mitotic progression in ER+ breast cancer cells, conferring drug resistance. | E2F8 confers cisplatin resistance to ER+ breast cancer cells via transcriptionally activating MASTL.
Tian J, Lin Y, Yu J. | 02/3/2018 |
| Study provides evidence that E2F8 functions as a proliferation-related oncogene in papillary thyroid cancer progression. Moreover, miR-144 appears to be a tumor suppressor through direct inhibition of E2F8. | E2F8, a direct target of miR-144, promotes papillary thyroid cancer progression via regulating cell cycle.
Sun J, Shi R, Zhao S, Li X, Lu S, Bu H, Ma X, Su C., Free PMC Article | 12/16/2017 |
| Results showed that E2F8 is up-regulated in metastatic prostate cancer and associated with poor prognosis. These results indicate that E2F8 is a crucial transcription regulator controlling cell cycle and survival in prostate cancer cells. | Geraniol suppresses prostate cancer growth through down-regulation of E2F8.
Lee S, Park YR, Kim SH, Park EJ, Kang MJ, So I, Chun JN, Jeon JH., Free PMC Article | 11/18/2017 |
| E2F8-mediated transcriptional repression is a critical tumor suppressor mechanism during postnatal liver development | E2f8 mediates tumor suppression in postnatal liver development.
Kent LN, Rakijas JB, Pandit SK, Westendorp B, Chen HZ, Huntington JT, Tang X, Bae S, Srivastava A, Senapati S, Koivisto C, Martin CK, Cuitino MC, Perez M, Clouse JM, Chokshi V, Shinde N, Kladney R, Sun D, Perez-Castro A, Matondo RB, Nantasanti S, Mokry M, Huang K, Machiraju R, Fernandez S, Rosol TJ, Coppola V, Pohar KS, Pipas JM, Schmidt CR, de Bruin A, Leone G., Free PMC Article | 09/30/2017 |
| transcription factor E2F8 is involved in the polyploidization during mouse and human decidualization | Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.
Qi QR, Zhao XY, Zuo RJ, Wang TS, Gu XW, Liu JL, Yang ZM., Free PMC Article | 04/23/2016 |
| E2F8 is overexpressed in Lung Cancer and is required for the growth of LC cells. E2F8 knockdown reduced the expression of UHRF1. These findings implicate E2F8 as a novel therapeutic target for LC treatment. | E2F8 as a Novel Therapeutic Target for Lung Cancer.
Park SA, Platt J, Lee JW, López-Giráldez F, Herbst RS, Koo JS., Free PMC Article | 10/17/2015 |
| The results identify E2F8 as a repressor and E2F1 as an activator of a transcriptional network controlling polyploidization in mammalian cells. | E2F8 is essential for polyploidization in mammalian cells.
Pandit SK, Westendorp B, Nantasanti S, van Liere E, Tooten PC, Cornelissen PW, Toussaint MJ, Lamers WH, de Bruin A. | 01/26/2013 |
| Analyses indicated that E2F8 could bind to regulatory elements of cyclin D1, regulating its transcription and promoting accumulation of S-phase cells. Findings suggest that E2F8 contributes to the oncogenic potential of HCC | E2F8 contributes to human hepatocellular carcinoma via regulating cell proliferation.
Deng Q, Wang Q, Zong WY, Zheng DL, Wen YX, Wang KS, Teng XM, Zhang X, Huang J, Han ZG. | 03/15/2010 |