| Knockdown of CENPU inhibits cervical cancer cell migration and stemness through the FOXM1/Wnt/beta-catenin pathway. | Knockdown of CENPU inhibits cervical cancer cell migration and stemness through the FOXM1/Wnt/β-catenin pathway.
Zhang X, Wang M, Zhang Y, Yang J, Duan W. | 03/30/2023 |
| Overexpression of MLF1IP promotes colorectal cancer cell proliferation through BRCA1/AKT/p27 signaling pathway. | Overexpression of MLF1IP promotes colorectal cancer cell proliferation through BRCA1/AKT/p27 signaling pathway.
Xu Y, Zhang L, Wang Q, Zheng M. | 04/2/2022 |
| Bub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure accurate chromosome segregation. | Bub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure accurate chromosome segregation.
Chen Q, Zhang M, Pan X, Yuan X, Zhou L, Yan L, Zeng LH, Xu J, Yang B, Zhang L, Huang J, Lu W, Fukagawa T, Wang F, Yan H. | 02/19/2022 |
| Centromere protein U (CENPU) promotes gastric cancer cell proliferation and glycolysis by regulating high mobility group box 2 (HMGB2). | Centromere protein U (CENPU) promotes gastric cancer cell proliferation and glycolysis by regulating high mobility group box 2 (HMGB2).
Deng T, Jiang X, He Z, Cai M, Chen C, Xu Z., Free PMC Article | 02/19/2022 |
| Abnormal Expression of Centromere Protein U Is Associated with Hepatocellular Cancer Progression. | Abnormal Expression of Centromere Protein U Is Associated with Hepatocellular Cancer Progression.
Yu Y, Chen X, Zhang W, Liu J., Free PMC Article | 01/22/2022 |
| Differential requirements for the CENP-O complex reveal parallel PLK1 kinetochore recruitment pathways. | Differential requirements for the CENP-O complex reveal parallel PLK1 kinetochore recruitment pathways.
Nguyen AL, Fadel MD, Cheeseman IM., Free PMC Article | 09/18/2021 |
| The lncRNA GATA3-AS1/miR-495-3p/CENPU axis predicts poor prognosis of breast cancer via the PLK1 signaling pathway. | The lncRNA GATA3-AS1/miR-495-3p/CENPU axis predicts poor prognosis of breast cancer via the PLK1 signaling pathway.
Lin S, Zhao M, Lv Y, Mao G, Ding S, Peng F., Free PMC Article | 07/24/2021 |
| BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis. | BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis.
Singh P, Pesenti ME, Maffini S, Carmignani S, Hedtfeld M, Petrovic A, Srinivasamani A, Bange T, Musacchio A., Free PMC Article | 02/2/2021 |
| Centromere protein U (CENPU) enhances angiogenesis in triple-negative breast cancer by inhibiting ubiquitin-proteasomal degradation of COX-2. | Centromere protein U (CENPU) enhances angiogenesis in triple-negative breast cancer by inhibiting ubiquitin-proteasomal degradation of COX-2.
Pan T, Zhou D, Shi Z, Qiu Y, Zhou G, Liu J, Yang Q, Cao L, Zhang J. | 01/9/2021 |
| Centromere protein U promotes cell proliferation, migration and invasion involving Wnt/beta-catenin signaling pathway in non-small cell lung cancer | Centromere protein U promotes cell proliferation, migration and invasion involving Wnt/β-catenin signaling pathway in non-small cell lung cancer.
Zhang Q, Li YD, Zhang SX, Shi YY. | 11/16/2019 |
| CENPU downregulation significantly inhibited LAC cell proliferation, migration and invasion in, which was possibly mediated by PI3K/AKT pathway inactivation | Reduced CENPU expression inhibits lung adenocarcinoma cell proliferation and migration through PI3K/AKT signaling.
Li J, Wang ZG, Pang LB, Zhang RH, Wang YY. | 07/20/2019 |
| In-depth IPA analysis revealed that CENPU was associated with the HMGB1 signaling pathway. qPCR and western blot analysis demonstrated that in the HMGB1 signaling pathway, CENPU knockdown downregulated expression levels of ILB, CXCL8, RAC1 and IL1A | Centromere protein U is a potential target for gene therapy of human bladder cancer.
Wang S, Liu B, Zhang J, Sun W, Dai C, Sun W, Li Q., Free PMC Article | 04/7/2018 |
| This study provides new insights and evidences that MLF1IP over-expression plays important roles in progression of luminal breast cancer. However, the precise cellular mechanisms for MLF1IP in luminal breast cancer need to be further explored. | MLF1IP is correlated with progression and prognosis in luminal breast cancer.
Huang DP, Luo RC. | 05/20/2017 |
| MLF1IP promotes normal erythroid proliferation and is involved in the pathogenesis of polycythemia vera. | MLF1IP promotes normal erythroid proliferation and is involved in the pathogenesis of polycythemia vera.
Feng G, Zhang T, Liu J, Ma X, Li B, Yang L, Zhang Y, Xu Z, Qin T, Zhou J, Huang G, Shi L, Xiao Z. | 05/20/2017 |
| MLF1IP significantly promotes prostate cancer cell proliferation and colony formation and significantly inhibits apoptosis without affecting cell cycle phase arrest in prostate cancer cell lines | MLF1 interacting protein: a potential gene therapy target for human prostate cancer?
Zhang L, Ji G, Shao Y, Qiao S, Jing Y, Qin R, Sun H, Shao C. | 10/17/2015 |
| Plk1 regulates the timing of the delocalization and ultimate destruction of the PBIP1.CENP-Q complex. | Mammalian Polo-like kinase 1 (Plk1) promotes proper chromosome segregation by phosphorylating and delocalizing the PBIP1·CENP-Q complex from kinetochores.
Park CH, Park JE, Kim TS, Kang YH, Soung NK, Zhou M, Kim NH, Bang JK, Lee KS., Free PMC Article | 06/6/2015 |
| Data propose that CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step that could be important for kinetochores switching into the correct conformation for microtubule-attachment. | Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex.
Eskat A, Deng W, Hofmeister A, Rudolphi S, Emmerth S, Hellwig D, Ulbricht T, Döring V, Bancroft JM, McAinsh AD, Cardoso MC, Meraldi P, Hoischen C, Leonhardt H, Diekmann S., Free PMC Article | 03/9/2013 |
| Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores. | Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores.
Kang YH, Park CH, Kim TS, Soung NK, Bang JK, Kim BY, Park JE, Lee KS., Free PMC Article | 08/6/2011 |
| CENP-U is a novel microtubule binding protein and plays an important role in kinetochore-microtubule attachment through its interaction with Hec1 | CENP-U cooperates with Hec1 to orchestrate kinetochore-microtubule attachment.
Hua S, Wang Z, Jiang K, Huang Y, Ward T, Zhao L, Dou Z, Yao X., Free PMC Article | 03/5/2011 |
| a possible role for MLF1IP deregulation in the genesis of erythroleukemias | cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP.
Hanissian SH, Akbar U, Teng B, Janjetovic Z, Hoffmann A, Hitzler JK, Iscove N, Hamre K, Du X, Tong Y, Mukatira S, Robertson JH, Morris SW. | 01/21/2010 |
| Deletion mutants of MLF1IP revealed that the N-terminal bipartite nuclear localization signal (NLS) was responsible for nucleolar targeting. | MLF1-interacting protein is mainly localized in nucleolus through N-terminal bipartite nuclear localization signal.
Suzuki H, Arakawa Y, Ito M, Saito S, Takeda N, Yamada H, Horiguchi-Yamada J. | 01/21/2010 |
| MLF1IP was found in glioblastomas where it was co-localized with MLF1 and nestin. Moreover, it was elevated in the contralateral brain where no tumor cells occurred, suggesting a role in glioma pathogenesis and potentially in other types of malignancies. | Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma.
Hanissian SH, Teng B, Akbar U, Janjetovic Z, Zhou Q, Duntsch C, Robertson JH. | 01/21/2010 |
| Plk1 self-regulates the Plk1-PBIP1 interaction to timely localize to the kinetochores and promote proper chromosome segregation. | Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation.
Kang YH, Park JE, Yu LR, Soung NK, Yun SM, Bang JK, Seong YS, Yu H, Garfield S, Veenstra TD, Lee KS. | 01/21/2010 |