| NLRX1 Mediates the Disruption of Intestinal Mucosal Function Caused by Porcine Astrovirus Infection via the Extracellular Regulated Protein Kinases/Myosin Light-Chain Kinase (ERK/MLCK) Pathway. | NLRX1 Mediates the Disruption of Intestinal Mucosal Function Caused by Porcine Astrovirus Infection via the Extracellular Regulated Protein Kinases/Myosin Light-Chain Kinase (ERK/MLCK) Pathway.
Tao J, Cheng J, Shi Y, Li B, Tang P, Jiao J, Liu H., Free PMC Article | 07/5/2024 |
| NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression. | NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression.
Ding Y, Sun W, Han M, Liu Z, Kang H, Ma X, Wang J, Mu H, Huang Y, Hou S, Sun D, Shen X, Wu X, Liu R. | 05/7/2024 |
| NLRX1: Versatile functions of a mitochondrial NLR protein that controls mitophagy. | NLRX1: Versatile functions of a mitochondrial NLR protein that controls mitophagy.
Bi PY, Killackey SA, Schweizer L, Girardin SE., Free PMC Article | 04/2/2024 |
| NLRX1 increases human retinal pigment epithelial autophagy and reduces H2O2-induced oxidative stress and inflammation by suppressing FUNDC1 phosphorylation and NLRP3 activation. | NLRX1 increases human retinal pigment epithelial autophagy and reduces H(2)O(2)-induced oxidative stress and inflammation by suppressing FUNDC1 phosphorylation and NLRP3 activation.
Wang Q, He F, Wu L. | 01/14/2023 |
| The regulatory role of NLRX1 in innate immunity and human disease. | The regulatory role of NLRX1 in innate immunity and human disease.
Liu M, Liu K, Cheng D, Zheng B, Li S, Mo Z. | 10/22/2022 |
| NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells. | NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells.
Jiao Q, Xu W, Guo X, Liu H, Liao B, Zhu X, Chen C, Yang F, Wu L, Xie C, Peng L., Free PMC Article | 04/23/2022 |
| Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific. | Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific.
Kastelberg B, Ayubi T, Tubau-Juni N, Leber A, Hontecillas R, Bassaganya-Riera J, Kale SD., Free PMC Article | 01/22/2022 |
| MicroRNA-195 suppresses enterovirus A71-induced pyroptosis in human neuroblastoma cells through targeting NLRX1. | MicroRNA-195 suppresses enterovirus A71-induced pyroptosis in human neuroblastoma cells through targeting NLRX1.
Zhu X, Wu T, Chi Y, Ge Y, Jiao Y, Zhu F, Cui L. | 10/9/2021 |
| Focusing on the Cell Type Specific Regulatory Actions of NLRX1. | Focusing on the Cell Type Specific Regulatory Actions of NLRX1.
Fekete T, Bencze D, Bíró E, Benkő S, Pázmándi K., Free PMC Article | 09/4/2021 |
| Behind the Scenes: Nod-Like Receptor X1 Controls Inflammation and Metabolism. | Behind the Scenes: Nod-Like Receptor X1 Controls Inflammation and Metabolism.
Snäkä T, Fasel N., Free PMC Article | 07/24/2021 |
| Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury. | Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury.
He B, Chen W, Zeng J, Tong W, Zheng P., Free PMC Article | 07/24/2021 |
| Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-kappaB and inflammasome signaling activation. | Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-κB and inflammasome signaling activation.
Koo JH, Kim SH, Jeon SH, Kang MJ, Choi JM. | 07/17/2021 |
| NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart. | NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart.
Zhang H, Xiao Y, Nederlof R, Bakker D, Zhang P, Girardin SE, Hollmann MW, Weber NC, Houten SM, van Weeghel M, Kibbey RG, Zuurbier CJ., Free PMC Article | 06/26/2021 |
| MiR-423-5p Regulates Cells Apoptosis and Extracellular Matrix Degradation via Nucleotide-Binding, Leucine-Rich Repeat Containing X1 (NLRX1) in Interleukin 1 beta (IL-1beta)-Induced Human Nucleus Pulposus Cells. | MiR-423-5p Regulates Cells Apoptosis and Extracellular Matrix Degradation via Nucleotide-Binding, Leucine-Rich Repeat Containing X1 (NLRX1) in Interleukin 1 beta (IL-1β)-Induced Human Nucleus Pulposus Cells.
Xu H, Ji L, Yu C, Chen Q, Ge Q, Lu Y., Free PMC Article | 02/20/2021 |
| HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING. | HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING.
Luo X, Donnelly CR, Gong W, Heath BR, Hao Y, Donnelly LA, Moghbeli T, Tan YS, Lin X, Bellile E, Kansy BA, Carey TE, Brenner JC, Cheng L, Polverini PJ, Morgan MA, Wen H, Prince ME, Ferris RL, Xie Y, Young S, Wolf GT, Chen Q, Lei YL., Free PMC Article | 01/2/2021 |
| mutations associated with multiple sclerosis | NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity.
Gharagozloo M, Mahmoud S, Simard C, Yamamoto K, Bobbala D, Ilangumaran S, Smith MD, Lamontagne A, Jarjoura S, Denault JB, Blais V, Gendron L, Vilariño-Güell C, Sadovnick AD, Ting JP, Calabresi PA, Amrani A, Gris D., Free PMC Article | 02/8/2020 |
| NLRX1 regulates TNF-alpha-induced mitochondria-lysosomal crosstalk to maintain the invasive and metastatic potential of breast cancer cells. | NLRX1 regulates TNF-α-induced mitochondria-lysosomal crosstalk to maintain the invasive and metastatic potential of breast cancer cells.
Singh K, Roy M, Prajapati P, Lipatova A, Sripada L, Gohel D, Singh A, Mane M, Godbole MM, Chumakov PM, Singh R. | 02/8/2020 |
| NLRX1 was downregulated in tumor tissue compared with adjacent normal liver tissue. Low tumor NLRX1 expression was identified as an independent indicator for HCC prognosis (recurrence: hazard ratio [HR] 1.87, 95% confidence interval [CI] 1.26-2.76, overall survival [OS] 2.26, 95% CI 1.44-3.56). NLRX1 over-expression (OE) significantly inhibited invasiveness ability and induced apoptosis in hepatocellular carcinoma cells. | NOD-like receptor X1 functions as a tumor suppressor by inhibiting epithelial-mesenchymal transition and inducing aging in hepatocellular carcinoma cells.
Hu B, Ding GY, Fu PY, Zhu XD, Ji Y, Shi GM, Shen YH, Cai JB, Yang Z, Zhou J, Fan J, Sun HC, Kuang M, Huang C., Free PMC Article | 10/26/2019 |
| NOD-like receptor X1 (NLRX1) positively regulates ATP-induced NLR Family, Pyrin Domain-Containing 3 Protein (NLRP3) inflammasome activation through mitochondrial reactive oxygen species in gingival epithelial cells (GECs). NLRX1 acts as a negative regulator of NF-kappaB signaling and IL-8 expression. NLRX1 stimulates detection of the pathogen Fusobacterium nucleatum via the inflammasome, while dampening cytokine produc... | NLRX1 modulates differentially NLRP3 inflammasome activation and NF-κB signaling during Fusobacterium nucleatum infection.
Hung SC, Huang PR, Almeida-da-Silva CLC, Atanasova KR, Yilmaz O, Ojcius DM., Free PMC Article | 09/14/2019 |
| Study shows that NLRX1 is a proviral host factor for HCV infection and functions as a negative regulator of the HCV-triggered innate immune response. NLRX1 is induced by HCV infection and interacts with MAVS, leading to K48 polyubiquitination and subsequent degradation of MAVS. Its nucleotide binding oligomerization domain is essential for NLRX1 to interact with PCBP2 and subsequently induce MAVS degradation. | NLRX1 Mediates MAVS Degradation To Attenuate the Hepatitis C Virus-Induced Innate Immune Response through PCBP2.
Qin Y, Xue B, Liu C, Wang X, Tian R, Xie Q, Guo M, Li G, Yang D, Zhu H., Free PMC Article | 06/8/2019 |
| NLRX1 expression was shown to be associated with angiogenesis, with a significant decrease in NLRX1 expression levels in fresh granulation tissue accompanied by high microvessel density after Negative-Pressure Wound Therapy. | Negative-Pressure Wound Therapy Promotes Wound Healing by Enhancing Angiogenesis Through Suppression of NLRX1 via miR-195 Upregulation.
Liu Y, Tang N, Cao K, Wang S, Tang S, Su H, Zhou J. | 02/23/2019 |
| Data show that NLRX1 specifically interacts with FASTKD5 and colocalizes with mitochondrial RNA granules. Further results suggest an important role of NLRX1 in regulating the post-transcriptional processing of mitochondrial RNA, which may have an important implication in bioenergetic adaptation during metabolic stress, oncogenic transformation and innate immunity. | NLRX1 resides in mitochondrial RNA granules and regulates mitochondrial RNA processing and bioenergetic adaptation.
Singh K, Sripada L, Lipatova A, Roy M, Prajapati P, Gohel D, Bhatelia K, Chumakov PM, Singh R. | 12/22/2018 |
| genetic association studies in Han population in southern China: Data suggest that, in subjects with type 2 diabetes, an SNP in NLRX1 (rs4245191) is associated with macro-vascular complications and cerebral infarction in the population studied; no such association was found for two other SNPs in NLRX1 (rs10790286, rs561830) or for two SNPs in TRAF6 (rs5030445, rs16928973). (TRAF6 = TNF receptor associated factor-6) | Interactions of TRAF6 and NLRX1 gene polymorphisms with environmental factors on the susceptibility of type 2 diabetes mellitus vascular complications in a southern Han Chinese population.
Zeng C, Zhou Z, Han Y, Wen Z, Guo C, Huang S, Xiao D, Ye X, Ou M, Huang C, Ye X, Yang G, Jing C, Nie L. | 06/30/2018 |
| Data show that NLRX1 suppresses tumorigenesis and reveals new genetic pathways involved in the pathobiology of histiocytic sarcoma. | NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-κB signaling.
Coutermarsh-Ott S, Simmons A, Capria V, LeRoith T, Wilson JE, Heid B, Philipson CW, Qin Q, Hontecillas-Magarzo R, Bassaganya-Riera J, Ting JP, Dervisis N, Allen IC., Free PMC Article | 02/17/2018 |
| NLRX1 exerted opposing regulatory effects on viral activation of the transcription factors IRF1 and IRF3. NLRX1 suppressed MAVS-mediated activation of IRF3, it conversely facilitated virus-induced increases in IRF1 expression and thereby enhanced control of viral infection. | NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR.
Feng H, Lenarcic EM, Yamane D, Wauthier E, Mo J, Guo H, McGivern DR, González-López O, Misumi I, Reid LM, Whitmire JK, Ting JP, Duncan JA, Moorman NJ, Lemon SM., Free PMC Article | 12/9/2017 |