| Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis. | Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis.
Zhang P, Frederick MI, Heinemann IU., Free PMC Article | 12/31/2022 |
| TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance. | TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance.
Yang A, Bofill-De Ros X, Stanton R, Shao TJ, Villanueva P, Gu S., Free PMC Article | 09/17/2022 |
| RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type. | RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type.
Medhi R, Price J, Furlan G, Gorges B, Sapetschnig A, Miska EA., Free PMC Article | 03/5/2022 |
| High ZCCHC6 expression is associated with head and neck squamous cell carcinoma. | Induction of ZCCHC6 expression in peripheral blood mononuclear cells by HNSCC secretions.
Arayataweegool A, Srisuttee R, Bin-Alee F, Mahattanasakul P, Tangjaturonrasme N, Kerekhanjanarong V, Mutirangura A, Kitkumthorn N. | 08/12/2020 |
| ZCCHC6 (TUT7) was markedly up-regulated in damaged cartilage from human osteoarthritis (OA) patients and from wild-type mice with surgically induced OA. | Genetic Inactivation of ZCCHC6 Suppresses Interleukin-6 Expression and Reduces the Severity of Experimental Osteoarthritis in Mice.
Ansari MY, Khan NM, Ahmad N, Green J, Novak K, Haqqi TM., Free PMC Article | 02/8/2020 |
| This tail-U-mediated repression (TUMR) is abolished in cells lacking the uridylation enzymes TUT4 and TUT7, indicating that uridylation alters miRNA function by modulating target recognition. We identified a set of non-canonical targets in human cells that are specifically regulated by uridylated miR-27a. | 3' Uridylation Confers miRNAs with Non-canonical Target Repertoires.
Yang A, Bofill-De Ros X, Shao TJ, Jiang M, Li K, Villanueva P, Dai L, Gu S., Free PMC Article | 01/18/2020 |
| Uridine residues added by TUT7 in the cytoplasm inhibit initiation of reverse transcription of LINE-1 mRNAs once they are reimported to the nucleus. | Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s.
Warkocki Z, Krawczyk PS, Adamska D, Bijata K, Garcia-Perez JL, Dziembowski A., Free PMC Article | 05/25/2019 |
| Results from a study on gene expression variability markers in early-stage human embryos shows that TUT7 (ZCCHC6) is a putative expression variability marker for the 3-day, 8-cell embryo stage. | Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
Hasegawa Y, Taylor D, Ovchinnikov DA, Wolvetang EJ, de Torrenté L, Mar JC., Free PMC Article | 07/23/2018 |
| Following an intratracheal challenge with S. pneumoniae, Zcchc6 deficiency led to a modest but significant increase in the expression of select cytokines including IL-6, CXCL1, and CXCL5. These findings were recapitulated in vitro whereby Zcchc6-deficient macrophages exhibited similar increases in cytokine expression due to bacterial stimulation | The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.
Kozlowski E, Wasserman GA, Morgan M, O'Carroll D, Ramirez NP, Gummuluru S, Rah JY, Gower AC, Ieong M, Quinton LJ, Mizgerd JP, Jones MR., Free PMC Article | 10/7/2017 |
| The authors found that TUT4(7) utilize two multidomain functional modules during the switch from either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU). | Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
Faehnle CR, Walleshauser J, Joshua-Tor L., Free PMC Article | 08/19/2017 |
| Knockdown of 3'hExo also altered the uridylation of histone mRNAs, suggesting that TUT7 and 3'hExo function together in trimming and uridylating histone mRNAs | TUT7 catalyzes the uridylation of the 3' end for rapid degradation of histone mRNA.
Lackey PE, Welch JD, Marzluff WF., Free PMC Article | 07/22/2017 |
| TUT7 generates an oligo-U tail in microRNAs that leads to degradation. | TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms.
Kim B, Ha M, Loeff L, Chang H, Simanshu DK, Li S, Fareh M, Patel DJ, Joo C, Kim VN., Free PMC Article | 10/3/2015 |
| Study identified TUT4 and TUT7 as uridylyl transferases for poly(A)+ mRNAs in humans and delineated in detail the action mechanism and molecular function of uridylation in the mRNA decay pathway. | Uridylation by TUT4 and TUT7 marks mRNA for degradation.
Lim J, Ha M, Chang H, Kwon SC, Simanshu DK, Patel DJ, Kim VN., Free PMC Article | 02/14/2015 |
| Study identified TUT7, TUT4, and TUT2 as novel components of the miRNA biogenesis pathway. | Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs.
Heo I, Ha M, Lim J, Yoon MJ, Park JE, Kwon SC, Chang H, Kim VN. | 01/12/2013 |
| Lin28 uses two different TUTases to control let-7 expression . | Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7).
Thornton JE, Chang HM, Piskounova E, Gregory RI., Free PMC Article | 12/8/2012 |