| High expression of HMBOX1 promotes the progression of lung squamous cell carcinoma. | High expression of HMBOX1 promotes the progression of lung squamous cell carcinoma.
Chen X, Zha G, Li C, Wang K. | 06/6/2024 |
| Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels. | Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels.
Zhou C, Wei W, Ma J, Yang Y, Liang L, Zhang Y, Wang Z, Chen X, Huang L, Wang W, Wu S., Free PMC Article | 11/22/2021 |
| TDD activates HMBOX1. | 5,2'-dibromo-2,4',5'-trihydroxydiphenylmethanone attenuates LPS-induced inflammation and ROS production in EA.hy926 cells via HMBOX1 induction.
Yuan HX, Feng XE, Liu EL, Ge R, Zhang YL, Xiao BG, Li QS., Free PMC Article | 04/18/2020 |
| The association of HMBOX1 and CD133 with gastric neoplasm cell proliferation and migration are reported; the use of the levels of these proteins as prognostic markers are discussed. | High expression of HMBOX1 contributes to poor prognosis of gastric cancer by promoting cell proliferation and migration.
Diao N, Li Y, Yang J, Jin C, Meng X, Jiao W, Feng J, Liu Z, Lu N. | 01/11/2020 |
| HMBOX1 in hepatocytes acts as a key immunosuppressive factor for inflammation | HMBOX1 in hepatocytes attenuates LPS/D-GalN-induced liver injury by inhibiting macrophage infiltration and activation.
Zhao H, Han Q, Lu N, Xu D, Tian Z, Zhang J. | 03/30/2019 |
| this study demonstrates for the first time that c-Fos/miR-18a/HMBOX1 axis plays a critical role in the progression of gliomas | c-Fos/microRNA-18a feedback loop modulates the tumor growth via HMBOX1 in human gliomas.
Zhou J, Wang M, Deng D. | 01/5/2019 |
| Low HMBOX1 expression is associated with liver cancer progression. | Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape.
Zhao H, Jia H, Han Q, Zhang J. | 11/17/2018 |
| HMBOX1 played important role in the high-grade serous ovarian cancer through regulation of proliferation and apoptosis. | Low expression level of HMBOX1 in high-grade serous ovarian cancer accelerates cell proliferation by inhibiting cell apoptosis.
Yu YL, Diao NN, Li YZ, Meng XH, Jiao WL, Feng JB, Liu ZP, Lu N. | 11/10/2018 |
| HMBOX1 may be a potential diagnostic marker in glioma. | Homeobox‑containing protein 1 loss is associated with clinicopathological performance in glioma.
Zhang P, Liu Q, Yan S, Yuan G, Shen J, Li G. | 05/19/2018 |
| Our data suggest a possible role of HMBOX1 in regulating radiosensitivity in cervical cancer cells. | Knockdown of homeobox containing 1 increases the radiosensitivity of cervical cancer cells through telomere shortening.
Zhou S, Xiao Y, Zhuang Y, Liu Y, Zhao H, Yang H, Xie C, Zhou F, Zhou Y. | 04/7/2018 |
| HMBOX1 regulates intracellular free zinc level by interacting with MT2A to inhibit apoptosis and promote autophagy in vascular endothelial cells. | HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells.
Ma H, Su L, Yue H, Yin X, Zhao J, Zhang S, Kung H, Xu Z, Miao J., Free PMC Article | 08/27/2016 |
| a homeobox-containing protein known as HMBOX1 can directly bind telomeric double-stranded DNA and associate with PML nuclear bodies. | The telomere-associated homeobox-containing protein TAH1/HMBOX1 participates in telomere maintenance in ALT cells.
Feng X, Luo Z, Jiang S, Li F, Han X, Hu Y, Wang D, Zhao Y, Ma W, Liu D, Huang J, Songyang Z., Free PMC Article | 04/26/2014 |
| HOT1 supports telomerase-dependent telomere elongation. | HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.
Kappei D, Butter F, Benda C, Scheibe M, Draškovič I, Stevense M, Novo CL, Basquin C, Araki M, Araki K, Krastev DB, Kittler R, Jessberger R, Londoño-Vallejo JA, Mann M, Buchholz F., Free PMC Article | 08/31/2013 |
| our results revealed a novel regulatory mechanism: miR-30c-1(*) promoted NK cell cytotoxicity against hepatoma cells by targeting HMBOX1. | miR-30c-1* promotes natural killer cell cytotoxicity against human hepatoma cells by targeting the transcription factor HMBOX1.
Gong J, Liu R, Zhuang R, Zhang Y, Fang L, Xu Z, Jin L, Wang T, Song C, Yang K, Wei Y, Yang A, Jin B, Chen L., Free PMC Article | 05/19/2012 |
| HMBOX1 may function as a negative regulator of IFN-gamma in NK cells. | HMBOX1, homeobox transcription factor, negatively regulates interferon-γ production in natural killer cells.
Wu L, Zhang C, Zheng X, Tian Z, Zhang J. | 04/28/2012 |
| HMBOX1 negatively regulates the expression of NKG2D and the activation of the NKG2D/DAP10 signaling pathway in NK cells. | HMBOX1 negatively regulates NK cell functions by suppressing the NKG2D/DAP10 signaling pathway.
Wu L, Zhang C, Zhang J., Free PMC Article | 01/14/2012 |
| higher HMGB1(homeobox containing 1) levels in Tracheal aspirates are associated with the development of bronchopulmonary dysplasia or death in ventilated premature infants. | High-mobility group box-1 protein in tracheal aspirates from premature infants: relationship with bronchopulmonary dysplasia and steroid therapy.
Aghai ZH, Saslow JG, Meniru C, Porter C, Eydelman R, Bhat V, Stahl G, Sannoh S, Pyon K, Hewitt C, Bhandari V. | 01/1/2011 |
| These findings suggest a distinct role of HMBOX1b, and the control of mRNA splicing might be involved in homeobox genes regulation. | Characterization of a novel human HMBOX1 splicing variant lacking the homeodomain and with attenuated transcription repressor activity.
Zhang M, Chen S, Li Q, Ling Y, Zhang J, Yu L. | 10/30/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| decreased expression in hepatic carcinoma | Recombinant expression of a novel human transcriptional repressor HMBOX1 and preparation of anti-HMBOX1 monoclonal antibody.
Dai J, Wu L, Zhang C, Zheng X, Tian Z, Zhang J., Free PMC Article | 03/1/2010 |
| Hmbox1 is widely expressed in pancreas and the expression of this gene can also be detected in pallium, hippocampus and hypothalamus | Isolation and functional analysis of human HMBOX1, a homeobox containing protein with transcriptional repressor activity.
Chen S, Saiyin H, Zeng X, Xi J, Liu X, Li X, Yu L. | 01/21/2010 |