| AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity. | AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity.
Ruiz M, Devkota R, Kaper D, Ruhanen H, Busayavalasa K, Radović U, Henricsson M, Käkelä R, Borén J, Pilon M., Free PMC Article | 07/7/2023 |
| Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings. | Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings.
Mihajlović M, Ninić A, Ostojić M, Sopić M, Stefanović A, Vekić J, Antonić T, Zeljković D, Trifunović B, Spasojević-Kalimanovska V, Bogavac Stanojević N, Jančić I, Zeljković A., Free PMC Article | 01/7/2023 |
| AdipoR2 inhibits human glioblastoma cell growth through the AMPK/mTOR pathway. | AdipoR2 inhibits human glioblastoma cell growth through the AMPK/mTOR pathway.
Jie C, Xuan W, Feng HD, Hua DM, Bo W, Fei S, Hao Z., Free PMC Article | 11/22/2021 |
| Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty acids. | Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty acids.
Ruiz M, Palmgren H, Henricsson M, Devkota R, Jaiswal H, Maresca M, Bohlooly-Y M, Peng XR, Borén J, Pilon M. | 07/3/2021 |
| The expression and relationship of AdipoR1/R2 in gastric intestinal metaplasia. | The expression and relationship of AdipoR1/R2 in gastric intestinal metaplasia.
Ayyildiz T, Dolar E, Ugras N, Dizdar OS, Erturk B, Adim SB, Yercı O. | 04/17/2021 |
| Adiponectin is associated with cardio-metabolic traits in Mexican children. | Adiponectin is associated with cardio-metabolic traits in Mexican children.
He J, Stryjecki C, Reddon H, Peralta-Romero J, Karam-Araujo R, Suarez F, Gomez-Zamudio J, Burguete-Garcia A, Alyass A, Cruz M, Meyre D., Free PMC Article | 10/24/2020 |
| Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins. | Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins.
Busayavalasa K, Ruiz M, Devkota R, Ståhlman M, Bodhicharla R, Svensk E, Hermansson NO, Borén J, Pilon M., Free PMC Article | 09/26/2020 |
| The primary cellular function of AdipoR2 is to maintain membrane fluidity in most human cell types and that adiponectin is not required for this function. | AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of adiponectin.
Ruiz M, Ståhlman M, Borén J, Pilon M., Free PMC Article | 08/15/2020 |
| Human diabetic kidneys show decreased intraglomerular AdipoR1/AdipoR2 expression. | The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes.
Kim Y, Lim JH, Kim MY, Kim EN, Yoon HE, Shin SJ, Choi BS, Kim YS, Chang YS, Park CW., Free PMC Article | 09/21/2019 |
| AdipoR2 single nucleotide polymorphism is associated with increases glomerular filtration rate. | Adiponectin Receptor gene Polymorphisms are Associated with Kidney Function in Elderly Japanese Populations.
Kobayashi H, Otsuka H, Yanai M, Hara M, Hishiki M, Soma M, Abe M., Free PMC Article | 07/13/2019 |
| There were no significant associations involving ADIPOR2 with diabetes and hypertriglyceridemia in an admixed Latin American population. | Variations in ADIPOR1 But Not ADIPOR2 are Associated With Hypertriglyceridemia and Diabetes in an Admixed Latin American Population.
Mora-García G, Ruiz-Díaz MS, Espitia-Almeida F, Gómez-Camargo D., Free PMC Article | 08/25/2018 |
| the findings of the present case-control study further exemplify the role of AdipoR2 genetic polymorphisms (rs10773989 and rs1044471) and its protein expression in colorectal carcinogenesis and advancement. | Associations of adiponectin receptor 2 (AdipoR2) gene polymorphisms and AdipoR2 protein expression levels with the risk of colorectal cancer: A case-control study.
Zhou L, Zhang HF, Ning W, Song X, Liu X, Liu JX., Free PMC Article | 05/26/2018 |
| Two polymorphisms, rs2241766 in ADIPOQ gene and rs10773989 in ADIPOR2 gene, especially under the recessive model of inheritance, played independent leading roles in susceptibility to myocardial infarction in Han Chinese. | Susceptibility of multiple polymorphisms in ADIPOQ, ADIPOR1 and ADIPOR2 genes to myocardial infarction in Han Chinese.
Zhang Z, Li Y, Yang X, Wang L, Xu L, Zhang Q. | 05/12/2018 |
| The results indicated that globular adiponectin inhibited the prooncogenic effects of leptin via AdipoR2-mediated suppression of UHRF1 | Globular adiponectin inhibits leptin-stimulated esophageal adenocarcinoma cell proliferation via adiponectin receptor 2-mediated suppression of UHRF1.
Wang J, Cheng Y, Yin X, Wu J, Luo Y, Wu J, Di J, Liu D, Huang Y, Zhang R, Zhang J. | 12/9/2017 |
| Variants of ADIPOR2 could be a determinant for higher FFA levels, and among Chinese Han population, carriers of the CT and TT genotypes for rs2370055 even with normal glucose levels may have significantly higher insulin resistance susceptibility. | A Variant in ADIPOR2 Is Associated with Increased Free Fatty Acid Levels in Chinese Population.
Yang G, Liu N, Hu M, Xin X, Han J, Cai Y, Hu Z, Jia C, Zhang M. | 11/11/2017 |
| We conclude that the PAQR-2 and AdipoR2 proteins share an evolutionarily conserved function that maintains membrane fluidity in the presence of exogenous saturated fatty acids. | The adiponectin receptor AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 prevent membrane rigidification by exogenous saturated fatty acids.
Devkota R, Svensk E, Ruiz M, Ståhlman M, Borén J, Pilon M., Free PMC Article | 10/14/2017 |
| Renoprotection of adiponectin is associated with improvement of the endothelial dysfunction, reduction of oxidative stress, and upregulation of endothelial nitric oxide synthase expression through activation of adenosine 5'-monophosphate-activated protein kinase by AdipoR1 and activation of peroxisome proliferator-activated receptor (PPAR)-alpha signaling pathway by AdipoR2. [review] | Adiponectin and Its Receptors in Diabetic Kidney Disease: Molecular Mechanisms and Clinical Potential.
Zha D, Wu X, Gao P. | 09/30/2017 |
| crystal structure of ADIPOR2 bound to a FFA molecule and show that ADIPOR2 possesses intrinsic basal ceramidase activity that is enhanced by adiponectin | Structural insights into adiponectin receptors suggest ceramidase activity.
Vasiliauskaité-Brooks I, Sounier R, Rochaix P, Bellot G, Fortier M, Hoh F, De Colibus L, Bechara C, Saied EM, Arenz C, Leyrat C, Granier S., Free PMC Article | 08/19/2017 |
| Adiponectin stimulates cPLA2 and COX-2 expression via AdipoR1/2-dependent activation of PKC/NADPH oxidase/mitochondria resulting in ROS accumulation, p300 phosphorylation, and histone H4 acetylation. | AdipoR-increased intracellular ROS promotes cPLA2 and COX-2 expressions via activation of PKC and p300 in adiponectin-stimulated human alveolar type II cells.
Chen HM, Yang CM, Chang JF, Wu CS, Sia KC, Lin WN. | 05/27/2017 |
| These results indicate that miR-150 can attenuate oxidized low-density lipoprotein - induced lipid accumulation in macrophages via promotion of cholesterol efflux. The suppressive effects of miR-150 on macrophage foam cell formation are mediated through targeting of AdipoR2. | microRNA-150 inhibits the formation of macrophage foam cells through targeting adiponectin receptor 2.
Li J, Zhang S. | 05/13/2017 |
| Decreased expression of ADIPOR2 is associated with polycystic ovary syndrome. | Evidence for decreased expression of APPL1 associated with reduced insulin and adiponectin receptors expression in PCOS patients.
Dehghan R, Saidijam M, Mehdizadeh M, Shabab N, Yavangi M, Artimani T. | 04/29/2017 |
| Strong Functional Association of adipor2 and cdh13 with adipoq | Revealing the Strong Functional Association of adipor2 and cdh13 with adipoq: A Gene Network Study.
Bag S, Anbarasu A. | 12/17/2016 |
| PCR results showed expression of adiponectin, AdipoR1, AdipoR2, follicle-stimulating hormone receptor (FSHR), and luteinizing hormone receptor (LHR) in granulosa cells (GCs). After controlling body mass index (BMI) values, qRT-PCR demonstrated a decreased expression of adiponectin system in GCs of polycystic ovary syndromepatients compared to those in controls | Downregulation of adiponectin system in granulosa cells and low levels of HMW adiponectin in PCOS.
Artimani T, Saidijam M, Aflatoonian R, Ashrafi M, Amiri I, Yavangi M, SoleimaniAsl S, Shabab N, Karimi J, Mehdizadeh M., Free PMC Article | 11/12/2016 |
| Endometriotic stromal cell proliferation is linked to increased expression of AdipoR2 (and AdipoR1) gene receptor expression. | in vitro Anti-Proliferative Effect of Adiponectin on Human Endometriotic Stromal Cells through AdipoR1 and AdipoR2 Gene Receptor Expression.
Bohlouli S, Rabzia A, Sadeghi E, Chobsaz F, Khazaei M., Free PMC Article | 09/17/2016 |
| Results identified miR-375 and its direct target, ADIPOR2 as androgen regulated molecules suggesting an important role in the mechanism of the increase in visceral fat mass and the associated insulin resistance caused by testosterone deficiency. | Inhibition of adipogenic differentiation of human SGBS preadipocytes by androgen-regulated microRNA miR-375.
Kraus M, Greither T, Wenzel C, Bräuer-Hartmann D, Wabitsch M, Behre HM. | 06/4/2016 |