| Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome. | Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome.
Rodríguez-Ortiz A, Montoya-Villegas JC, García-Vallejo F, Mina-Paz Y., Free PMC Article | 02/19/2022 |
| Prognostic value of HMGN family expression in acute myeloid leukemia. | Prognostic value of HMGN family expression in acute myeloid leukemia.
Cui W, Liu Y, Tan Y, Peng X, Cui L, Cheng Z, Dai Y, Fu L, Zeng T, Liu Y. | 10/2/2021 |
| HMGN5 promotes invasion and migration of colorectal cancer through activating FGF/FGFR pathway. | HMGN5 promotes invasion and migration of colorectal cancer through activating FGF/FGFR pathway.
Zhu GJ, Liu F, Xu YG, Zhao CX, Zhao JG, Sun C. | 09/18/2021 |
| HMGN5 Silencing Suppresses Cell Biological Progression via AKT/MAPK Pathway in Human Glioblastoma Cells. | HMGN5 Silencing Suppresses Cell Biological Progression via AKT/MAPK Pathway in Human Glioblastoma Cells.
Ma Q, Wang X, Wang H, Song W, Wang Q, Wang J., Free PMC Article | 04/3/2021 |
| HIF1A upregulated the transcription factor GATA1 and further promoted the expression of HMGN5. | Hypoxia-Inducible Factor 1A Upregulates HMGN5 by Increasing the Expression of GATA1 and Plays a Role in Osteosarcoma Metastasis.
Xu E, Ji Z, Jiang H, Lin T, Ma J, Zhou X., Free PMC Article | 06/13/2020 |
| HMGN5 mRNA levels were significantly elevated in bladder transitional cell carcinoma tissue compared to controls. | HMGN5 expression in bladder cancer tissue and its role on prognosis.
Wu J, Wang J. | 11/9/2019 |
| MiR-183-3p regulated HMGN5 expression in prostate cancer cells. | microRNA-183-3p Inhibits Progression of Human Prostate Cancer by Downregulating High-Mobility Group Nucleosome Binding Domain 5.
Li Y, He S, Zhan Y, He A, Gong Y, Ji G, Huang C, Peng D, Guan B, Li X, Zhou L. | 08/24/2019 |
| Findings suggest that a miR-140-5p/HMGN5/autophagy regulatory loop plays a critical role in chemoresistance in osteosarcoma. In conclusion, our data elucidated that miR-140-5p promoted autophagy mediated by HMGN5 and sensitized osteosarcoma cells to chemotherapy. | MicroRNA-140-5p regulates osteosarcoma chemoresistance by targeting HMGN5 and autophagy.
Meng Y, Gao R, Ma J, Zhao J, Xu E, Wang C, Zhou X., Free PMC Article | 09/1/2018 |
| High HMGN5 expression is associated with osteosarcoma invasion. | Overexpression of microRNA-495 suppresses the proliferation and invasion and induces the apoptosis of osteosarcoma cells by targeting high-mobility group nucleosome-binding domain 5.
Jiang W, Zheng J, Yu T, Wang J. | 07/28/2018 |
| We observed decreased miR-409-3p expression in glioma, and overexpression of miR-409-3p repressed glioma cell invasion and proliferation by targeting HMGN5, an oncogene associated with glioma | MicroRNA-409-3p Represses Glioma Cell Invasion and Proliferation by Targeting High-Mobility Group Nucleosome-Binding Domain 5.
Cao Y, Zhang L, Wei M, Jiang X, Jia D., Free PMC Article | 04/28/2018 |
| HMGN5 regulated the expression of multidrug resistance 1, cyclin B1, and Bcl-2. | Silencing HMGN5 suppresses cell growth and promotes chemosensitivity in esophageal squamous cell carcinoma.
Liu X, Ma W, Yan Y, Wu S. | 02/24/2018 |
| NSBP1 was highly expressed in NSCLC cells. NSBP1 siRNA knockdown suppressed NSCLC cell proliferation and invasion. miR326 has a putative binding site in the NSBP1 3'UTR. NSBP1 overexpression abolished miR326 inhibition of cyclin B1 and MMP9 expression. | Suppression of nucleosome-binding protein 1 by miR-326 impedes cell proliferation and invasion in non-small cell lung cancer cells.
Li D, Du X, Liu A, Li P. | 10/22/2016 |
| HMGN5 overexpression is correlated with advanced pathological grade and poorer prognosis in meningiomas | HMGN5 blockade by siRNA enhances apoptosis, suppresses invasion and increases chemosensitivity to temozolomide in meningiomas.
He J, Liu C, Wang B, Li N, Zuo G, Gao D. | 08/13/2016 |
| Decreased miR-340 expression may contribute to the development and progression of prostate cancer through a mechanism that involves HMGN5. | microRNA-340 Suppresses Tumorigenic Potential of Prostate Cancer Cells by Targeting High-Mobility Group Nucleosome-Binding Domain 5.
Wei P, Qiao B, Li Q, Han X, Zhang H, Huo Q, Sun J. | 05/28/2016 |
| Our data first time identified miR-186 as the upstream regulator of NSBP1 | MiR-186 suppresses the growth and metastasis of bladder cancer by targeting NSBP1.
Yao K, He L, Gan Y, Zeng Q, Dai Y, Tan J., Free PMC Article | 04/2/2016 |
| High HMGN5 expression is associated with urothelial bladder cancer. | Knockdown of HMGN5 suppresses the viability and invasion of human urothelial bladder cancer 5637 cells in vitro and in vivo.
Gan Y, Tan J, Yang J, Zhou Y, Dai Y, He L, Yao K, Tang Y. | 03/26/2016 |
| HMGN5 is an oncogene and plays an important role in prostate cancer tumorigenesis and progression. the level of HMGN5 may be used as a biomarker to predict the patients that would benefit from gemcitabine treatment. | Expression of oncogenic HMGN5 increases the sensitivity of prostate cancer cells to gemcitabine.
Guo Z, Zhang X, Li X, Xie F, Su B, Zhang M, Zhou L. | 12/5/2015 |
| HMGN5 plays an oncogenic role in human breast cancer by inhibiting cell proliferation and invasion, and activating apoptosis, which could be exploited as a target for therapy in human breast cancer. | The high-mobility group nucleosome-binding domain 5 is highly expressed in breast cancer and promotes the proliferation and invasion of breast cancer cells.
Weng M, Song F, Chen J, Wu J, Qin J, Jin T, Xu J. | 06/20/2015 |
| HMGN5 knockdown sensitizes prostate cancer cells to ionizing radiation | HMGN5 knockdown sensitizes prostate cancer cells to ionizing radiation.
Su B, Shi B, Tang Y, Guo Z, Yu X, He X, Li X, Gao X, Zhou L. | 02/7/2015 |
| HMGN5 plays oncogenic role in osteosarcoma by promoting cell proliferation and invasion, and could be exploited as a target for therapy in osteosarcoma. | The expression and clinical significance of high mobility group nucleosome binding domain 5 in human osteosarcoma.
Zhou X, Yuan B, Yuan W, Wang C, Gao R, Wang J. | 10/11/2014 |
| HMGN5 is a critical factor in the development of chemoresistance through regulating autophagy, and it offers a novel target for improving osteosarcoma therapy. | High-mobility group nucleosome-binding domain 5 increases drug resistance in osteosarcoma through upregulating autophagy.
Yang C, Gao R, Wang J, Yuan W, Wang C, Zhou X. | 10/11/2014 |
| Data indicate that cells lacking either high mobility group protein N5 (HMGN5) and lamina-associated polypeptide 2alpha (LAP2alpha) showed that loss of either protein affects the genome-wide distribution of the remaining partner. | High mobility group protein N5 (HMGN5) and lamina-associated polypeptide 2α (LAP2α) interact and reciprocally affect their genome-wide chromatin organization.
Zhang S, Schones DE, Malicet C, Rochman M, Zhou M, Foisner R, Bustin M., Free PMC Article | 09/7/2013 |
| HMGN5 silencing to significantly inhibit A549 and H1299 cell proliferation. | Knockdown of HMGN5 expression by RNA interference induces cell cycle arrest in human lung cancer cells.
Chen P, Wang XL, Ma ZS, Xu Z, Jia B, Ren J, Hu YX, Zhang QH, Ma TG, Yan BD, Yan QZ, Li YL, Li Z, Yu JY, Gao R, Fan N, Li B, Yang JL. | 06/8/2013 |
| HMGN5 may be a potential molecular target with therapeutic relevance for the treatment of prostate cancer. | Small interfering RNA targeting HMGN5 induces apoptosis via modulation of a mitochondrial pathway and Bcl-2 family proteins in prostate cancer cells.
Zhang XY, Guo ZQ, Ji SQ, Zhang M, Jiang N, Li XS, Zhou LQ., Free PMC Article | 09/22/2012 |
| NSBP1 plays oncogenic role in clear cell renal cell carcinoma (ccRCC) by promoting cell proliferation and invasion. | Knockdown of the nucleosome binding protein 1 inhibits the growth and invasion of clear cell renal cell carcinoma cells in vitro and in vivo.
Ji SQ, Yao L, Zhang XY, Li XS, Zhou LQ., Free PMC Article | 08/25/2012 |