| TNFAIP3 interacting protein 2 relieves lipopolysaccharide (LPS)-induced inflammatory injury in endometritis by inhibiting NF-kappaB activation. | TNFAIP3 interacting protein 2 relieves lipopolysaccharide (LPS)-induced inflammatory injury in endometritis by inhibiting NF-kappaB activation.
Qian X, Wang Y, Li X, Li Y, Li L., Free PMC Article | 11/1/2023 |
| TNIP2 inhibits amyloidogenesis by regulating the 3'UTR of BACE1: An in vitro study. | TNIP2 inhibits amyloidogenesis by regulating the 3'UTR of BACE1: An in vitro study.
Chen L, Wang L, Zhou GF, Liu Y, Chen X, Xie XY, Wen QX, Li CL, Yang J, Chen GJ. | 06/19/2023 |
| Long noncoding RNA NAV2-AS5 relieves chondrocyte inflammation by targeting miR-8082/TNIP2 in osteoarthritis. | Long noncoding RNA NAV2-AS5 relieves chondrocyte inflammation by targeting miR-8082/TNIP2 in osteoarthritis.
Wang P, Wang Y, Ma B., Free PMC Article | 03/16/2023 |
| TNIP2 mediates GRbeta-promoted inflammation and is associated with severity of major depressive disorder. | TNIP2 mediates GRβ-promoted inflammation and is associated with severity of major depressive disorder.
Chiang TI, Hung YY, Wu MK, Huang YL, Kang HY. | 07/17/2021 |
| The increased inflammation of Map3k8(-/-) mice in allergic airway inflammation and colitis results from reduced ABIN-2 signaling, rather than blocked TPL-2 signaling. | ABIN-2, of the TPL-2 Signaling Complex, Modulates Mammalian Inflammation.
Webb LV, Ventura S, Ley SC. | 09/19/2020 |
| the data indicated that TNIP2 is significantly decreased in MODS following severe trauma, and it plays a protective role in MODS development by inhibiting the inflammation response and oxidative stress by preventing NFkappaB activation. | Expression and role of TNIP2 in multiple organ dysfunction syndrome following severe trauma.
Gong H, Sheng X, Xue J, Zhu D. | 08/3/2019 |
| RelAp43 interacts with the p105-ABIN2-TPL2 complex and we observe a strong perturbation of this complex in presence of M protein. | Regulation of NF-κB by the p105-ABIN2-TPL2 complex and RelAp43 during rabies virus infection.
Besson B, Sonthonnax F, Duchateau M, Ben Khalifa Y, Larrous F, Eun H, Hourdel V, Matondo M, Chamot-Rooke J, Grailhe R, Bourhy H., Free PMC Article | 11/25/2017 |
| Study reports the crystal structure of hABIN2 in complex with linear triubiquitin, which shows the ubiquitins with M1-linkage could form a right-handed helical trimer when bridging two hABIN2 dimers, and thus allow the assembly of a higher-order signaling complex with A20. | Structural Insights into Linear Tri-ubiquitin Recognition by A20-Binding Inhibitor of NF-κB, ABIN-2.
Lin SM, Lin SC, Hong JY, Su TW, Kuo BJ, Chang WH, Tu YF, Lo YC. | 10/21/2017 |
| Findings suggest an expanded role for the NF-kappaB network hub protein TNIP2 and reveals an association between TNIP2 and YLPM1, TNIP2 and ESCRT-I, together with many RNA processing proteins and a distinct set of mRNAs. | TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.
Banks CA, Boanca G, Lee ZT, Eubanks CG, Hattem GL, Peak A, Weems LE, Conkright JJ, Florens L, Washburn MP., Free PMC Article | 06/27/2017 |
| miR-1180 might act as a tumor promoter by targeting TNIP2 during development of hepatocellular carcinoma. | MiR-1180 promoted the proliferation of hepatocellular carcinoma cells by repressing TNIP2 expression.
Zhou X, Zhu HQ, Ma CQ, Li HG, Liu FF, Chang H, Lu J. | 12/31/2016 |
| miR let-7a-regulated USP35 can inhibit NF-kappaB activation by deubiquitination and stabilization of ABIN-2 protein | USP35 activated by miR let-7a inhibits cell proliferation and NF-κB activation through stabilization of ABIN-2.
Liu C, Wang L, Chen W, Zhao S, Yin C, Lin Y, Jiang A, Zhang P., Free PMC Article | 08/20/2016 |
| ABIN-2 acts as a positive regulator of NF-kappaB-dependent transcription by activating IKKalpha. | A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity.
Leotoing L, Chereau F, Baron S, Hube F, Valencia HJ, Bordereaux D, Demmers JA, Strouboulis J, Baud V., Free PMC Article | 11/26/2011 |
| A20, ABIN-1/2, and CARD11 mutations have prognostic value in gastrointestinal diffuse large B-cell lymphoma | A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma.
Dong G, Chanudet E, Zeng N, Appert A, Chen YW, Au WY, Hamoudi RA, Watkins AJ, Ye H, Liu H, Gao Z, Chuang SS, Srivastava G, Du MQ. | 07/23/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW, Padyukov L, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P, YEAR Consortium, Altshuler D, Karlson EW, Toes RE, de Vries N, Begovich AB, Siminovitch KA, Worthington J, Klareskog L, Gregersen PK, Daly MJ, Plenge RM., Free PMC Article | 12/2/2009 |
| This review defines ABIN-2 based on three different parameters: ability to bind A20; ability to inhibit NF-kappaB activation upon overexpression; the presence of specific short amino acid regions of strong homology, designated ABIN homology domains. | ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling.
Verstrepen L, Carpentier I, Verhelst K, Beyaert R. | 01/21/2010 |
| role for an ABIN-sensitive non-classical NF-kappaB signalling pathway in the proliferation of EGFR-overexpressing tumour cells. | ABINs inhibit EGF receptor-mediated NF-kappaB activation and growth of EGF receptor-overexpressing tumour cells.
Huang L, Verstrepen L, Heyninck K, Wullaert A, Revets H, De Baetselier P, Beyaert R. | 01/21/2010 |
| transcription repressed by promyelocytic leukemia protein expression | The promyelocytic leukemia protein represses A20-mediated transcription.
Wu WS, Xu ZX, Chang KS. | 01/21/2010 |
| optimal TPL-2 stability in vivo requires interaction with ABIN-2 as well as p105 | ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.
Lang V, Symons A, Watton SJ, Janzen J, Soneji Y, Beinke S, Howell S, Ley SC., Free PMC Article | 01/21/2010 |
| Endothelial tyrosine kinase Tie2 interacts with ABIN-2. | The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2.
Hughes DP, Marron MB, Brindle NP. | 01/21/2010 |
| Thus, CIH-mediated NF-kappaB activation may be a molecular mechanism linking OSA and cardiovascular pathologies seen in OSA patients. | Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo.
Greenberg H, Ye X, Wilson D, Htoo AK, Hendersen T, Liu SF. | 01/21/2010 |
| FLIP1 has a role in the regulation of NF-kappaB activity related to the role of LKB1 in tumor suppression | An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation.
Liu WK, Chien CY, Chou CK, Su JY. | 01/21/2010 |
| ABIN-2 exerts unexpected function in mediating transcriptional coactivation. | The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation.
Chien CY, Liu WK, Chou CK, Su JY. | 01/21/2010 |
| ABIN-2 may function as a negative regulator that downregulates NF-kappaB activation during liver regeneration | Overexpression of ABIN-2, a negative regulator of NF-kappaB, delays liver regeneration in the ABIN-2 transgenic mice.
Li CC, Chou CK, Wang MH, Tsai TF. | 01/21/2010 |
| ABIN-2 was found to inhibit endothelial apoptosis and rescue cells from death following growth factor deprivation. Deletion of the carboxy-terminus of ABIN-2 removed its ability to inhibit apoptosis. | ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1.
Tadros A, Hughes DP, Dunmore BJ, Brindle NP. | 01/21/2010 |
| Thus the present results showed a correlation between NF-kappaB activation and the repair of sublethal damage in split-dose irradiation. | Nuclear accumulation and activation of nuclear factor kappaB after split-dose irradiation in LS174T cells.
Liu Y, Nakahara T, Miyakoshi J, Hu DL, Nakane A, Abe Y. | 01/21/2010 |