| Phosphorylation of Dab2 is involved in inhibited VEGF-VEGFR-2 signaling induced by downregulation of syndecan-1 in glomerular endothelial cell. | Phosphorylation of Dab2 is involved in inhibited VEGF-VEGFR-2 signaling induced by downregulation of syndecan-1 in glomerular endothelial cell.
Jing Z, Jia-Jun W, Wei-Jie Y. | 10/3/2020 |
| showed that Dab2 expression in cultured tubular epithelial cells is involved in endocytic regulation and that it also protects cells from TGF-beta-induced epithelial-to-mesenchymal transition | Getting a Notch closer to renal dysfunction: activated Notch suppresses expression of the adaptor protein Disabled-2 in tubular epithelial cells.
Schütte-Nütgen K, Edeling M, Mendl G, Krahn MP, Edemir B, Weide T, Kremerskothen J, Michgehl U, Pavenstädt H. | 08/24/2019 |
| these findings suggest that both isoforms of Dab-2 are transiently upregulated in response to SCI and that the increased expression of Dab-2 is associated with the early activation of macrophages and astrogliosis | Transient activation of an adaptor protein, disabled-2, in rat spinal cord injury.
Ahn M, Moon C, Park C, Kim J, Sim KB, Shin T. | 09/26/2015 |
| We conclude that the megalin/cubilin/amnionless/Dab2 complex/es participate in intestinal processes, mainly during the lactation period and that Dab2 may act as an adaptor in intestinal processes mediated by ApoER2 and VLDLR. | Dab2, megalin, cubilin and amnionless receptor complex might mediate intestinal endocytosis in the suckling rat.
Vázquez-Carretero MD, Palomo M, García-Miranda P, Sánchez-Aguayo I, Peral MJ, Calonge ML, Ilundain AA. | 10/25/2014 |
| Dietary resistant starch normalized megalin and Dab2 mRNA overexpression in diabetic rats. | Dietary resistant starch prevents urinary excretion of 25-hydroxycholecalciferol and vitamin D-binding protein in type 1 diabetic rats.
Smazal AL, Borcherding NC, Anderegg AS, Schalinske KL, Whitley EM, Rowling MJ. | 08/31/2013 |
| The data demonstrated a novel and critical role for miR-145 expression as a regulator of Dab2 expression and beta-catenin activity in response to TGF-beta1 and hypoxia. | miR-145 is differentially regulated by TGF-β1 and ischaemia and targets Disabled-2 expression and wnt/β-catenin activity.
Mayorga ME, Penn MS., Free PMC Article | 09/22/2012 |
| loss of Dab2 expression was sufficient to induce mesenchymal stem cell cardiac proteins expression and improve cardiac function after engraftment following infarction | Central role for disabled-2 in mesenchymal stem cardiac protein expression and functional consequences after engraftment in acute myocardial infarction.
Mayorga ME, Dong F, Sundararaman S, Huang Y, Jiang Y, Howe PH, Penn MS. | 08/6/2011 |
| Regulation of Dab2 expression in intestinal and renal epithelia by development | Regulation of Dab2 expression in intestinal and renal epithelia by development.
Vázquez-Carretero MD, García-Miranda P, Calonge ML, Peral MJ, Ilundáin AA. | 07/23/2011 |
| NMHC-IIA is functionally linked to megalin by interaction with Dab2 and is likely involved in megalin-mediated endocytosis in proximal tubule cells. | Megalin and nonmuscle myosin heavy chain IIA interact with the adaptor protein Disabled-2 in proximal tubule cells.
Hosaka K, Takeda T, Iino N, Hosojima M, Sato H, Kaseda R, Yamamoto K, Kobayashi A, Gejyo F, Saito A. | 01/21/2010 |
| Suggest a role for DOC-2 in cardiac remodeling involving collagen expression during chronic hemodynamic overload. | Adapter molecule DOC-2 is differentially expressed in pressure and volume overload hypertrophy and inhibits collagen synthesis in cardiac fibroblasts.
Kumbar DH, VanBergen A, Ocampo C, Muangmingsuk S, Griffin AJ, Gupta M. | 01/21/2010 |
| This study defines a role of DAB2 in the control of neuronal plasticity and demonstrates for the first time that DAB2 is a negative regulator in nerve growth factor-mediated neurite outgrowth. | Evaluation of the role of Disabled-2 in nerve growth factor-mediated neurite outgrowth and cellular signalling.
Huang CH, Cheng JC, Chen JC, Tseng CP. | 01/21/2010 |
| Dab2 may therefore be a modulator of aldosterone secretion and be involved in mineralocorticoid secretion abnormalities. | Disabled-2 is expressed in adrenal zona glomerulosa and is involved in aldosterone secretion.
Romero DG, Yanes LL, de Rodriguez AF, Plonczynski MW, Welsh BL, Reckelhoff JF, Gomez-Sanchez EP, Gomez-Sanchez CE. | 01/21/2010 |