| HNRNPC promotes estrogen receptor-positive breast cancer cell cycle by stabilizing WDR77 mRNA in an m6A-dependent manner. | HNRNPC promotes estrogen receptor-positive breast cancer cell cycle by stabilizing WDR77 mRNA in an m6A-dependent manner.
Xu W, Huang Z, Xiao Y, Li W, Xu M, Zhao Q, Yi P. | 04/25/2024 |
| Inhibition of PRMT5/MEP50 Arginine Methyltransferase Activity Causes Cancer Vulnerability in NDRG2[low] Adult T-Cell Leukemia/Lymphoma. | Inhibition of PRMT5/MEP50 Arginine Methyltransferase Activity Causes Cancer Vulnerability in NDRG2(low) Adult T-Cell Leukemia/Lymphoma.
Ichikawa T, Suekane A, Nakahata S, Iha H, Shimoda K, Murakami T, Morishita K., Free PMC Article | 03/20/2024 |
| HBx represses WDR77 to enhance HBV replication by DDB1-mediated WDR77 degradation in the liver. | HBx represses WDR77 to enhance HBV replication by DDB1-mediated WDR77 degradation in the liver.
Yuan H, Zhao L, Yuan Y, Yun H, Zheng W, Geng Y, Yang G, Wang Y, Zhao M, Zhang X., Free PMC Article | 01/29/2022 |
| Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5-MEP50 Complex. | Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5-MEP50 Complex.
Krzyzanowski A, Gasper R, Adihou H, Hart P', Waldmann H., Free PMC Article | 01/1/2022 |
| Germ-line mutations in WDR77 predispose to familial papillary thyroid cancer. | Germ-line mutations in WDR77 predispose to familial papillary thyroid cancer.
Zhao Y, Yu T, Sun J, Wang F, Cheng C, He S, Chen L, Xie D, Fu L, Guan X, Yan A, Li Y, Miao G, Zhu X., Free PMC Article | 12/11/2021 |
| WD Repeat Domain 77 Protein Regulates Translation of E2F1 and E2F3 mRNA. | WD Repeat Domain 77 Protein Regulates Translation of E2F1 and E2F3 mRNA.
Altayyar MA, Sheng X, Wang Z., Free PMC Article | 12/19/2020 |
| These results suggest that MEP50/PRMT5 is important for HH signal-induced GLI1 activation, especially in cancers. | MEP50/PRMT5-mediated methylation activates GLI1 in Hedgehog signalling through inhibition of ubiquitination by the ITCH/NUMB complex.
Abe Y, Suzuki Y, Kawamura K, Tanaka N., Free PMC Article | 04/4/2020 |
| curcumin affects the PRMT5-MEP50 methyltransferase expression might be explored for its therapeutic application. | Curcumin ameliorates PRMT5-MEP50 arginine methyltransferase expression by decreasing the Sp1 and NF-YA transcription factors in the A549 and MCF-7 cells.
Chatterjee B, Ghosh K, Suresh L, Kanade SR. | 04/27/2019 |
| Deacetylation of WDR77 at Lys-3 and Lys-243 suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity. | Sirtuin 7-mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity.
Qi H, Shi X, Yu M, Liu B, Liu M, Song S, Chen S, Zou J, Zhu WG, Luo J., Free PMC Article | 04/13/2019 |
| A 3.7 A structure of PRMT5, solved in complex with regulatory binding subunit MEP50 (methylosome associated protein 50, WDR77, p44), by single particle (SP) cryo-Electron Microscopy (cryo-EM) using micrographs of particles that are visibly crowded and aggregated. The catalytic PRMT5 subunits form a core tetramer and the MEP50 subunits are arranged peripherally in complex with the PRMT5 N-terminal domain. | Cryo-electron microscopy structure of a human PRMT5:MEP50 complex.
Timm DE, Bowman V, Madsen R, Rauch C., Free PMC Article | 06/30/2018 |
| Data indicate that ZNF326 is an interaction partner and substrate of the PRMT5/WDR77 complex. | The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.
Rengasamy M, Zhang F, Vashisht A, Song WM, Aguilo F, Sun Y, Li S, Zhang W, Zhang B, Wohlschlegel JA, Walsh MJ., Free PMC Article | 12/2/2017 |
| In an in vitro assay of vascular smooth muscle cells, circRNA WDR77 silencing significantly inhibited cell proliferation and migration. Bioinformatics methods revealed that miR-124 and fibroblast growth factor 2 (FGF-2) were downstream targets of circRNA WDR77. | Circular RNA WDR77 target FGF-2 to regulate vascular smooth muscle cells proliferation and migration by sponging miR-124.
Chen J, Cui L, Yuan J, Zhang Y, Sang H. | 11/18/2017 |
| SFN treatment of tumors results in reduced MEP50 level and H4R3me2s formation, confirming that that SFN impacts this complex in vivo. These studies suggest that the PRMT5/MEP50 is required for tumor growth and that reduced expression of this complex is a part of the mechanism of SFN suppression of tumor formation. | Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation.
Saha K, Fisher ML, Adhikary G, Grun D, Eckert RL., Free PMC Article | 10/7/2017 |
| Results provide evidence that PRMT5 and p44 regulate gene expression of growth and anti-growth factors to promote lung tumorigenesis. | Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation.
Sheng X, Wang Z., Free PMC Article | 09/30/2017 |
| TSC22D2 protein might be a member of the PRMT5 complex via direct binding of WDR77. | Yeast two-hybrid screening identified WDR77 as a novel interacting partner of TSC22D2.
Li Q, Chen P, Zeng Z, Liang F, Song Y, Xiong F, Li X, Gong Z, Zhou M, Xiang B, Peng C, Li X, Chen X, Li G, Xiong W. | 02/18/2017 |
| MEP50 genes reduces gene expression through histone arginine methylation in keratinocytes. | MEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCδ/p38δ Signaling.
Saha K, Adhikary G, Eckert RL., Free PMC Article | 05/21/2016 |
| MEP50 can transform cells independent of AR and ER. | Methylosome protein 50 promotes androgen- and estrogen-independent tumorigenesis.
Wei TY, Hsia JY, Chiu SC, Su LJ, Juan CC, Lee YC, Chen JM, Chou HY, Huang JY, Huang HM, Yu CT. | 07/25/2015 |
| Data indicate that MEP50 WD repeat protein is essential for methylation of histones H4 and H2A by PRMT5 arginine methyltransferase. | Histone H2A and H4 N-terminal tails are positioned by the MEP50 WD repeat protein for efficient methylation by the PRMT5 arginine methyltransferase.
Burgos ES, Wilczek C, Onikubo T, Bonanno JB, Jansong J, Reimer U, Shechter D., Free PMC Article | 06/27/2015 |
| These findings characterize PKG as a novel regulator of AR-mediated transcription by enhancing AR cofactor p44/WDR77's function. | cGMP-dependent protein kinase Iβ interacts with p44/WDR77 to regulate androgen receptor-driven gene expression.
Zhou L, Hosohata K, Gao S, Gu Z, Wang Z., Free PMC Article | 01/31/2015 |
| Data indicate a transcription complex androgen receptor (AR)-p44-Smad1, and confirmed for physical interaction by co-immunoprecipitaion. | Functional domains of androgen receptor coactivator p44/Mep50/WDR77and its interaction with Smad1.
Li Y, Tian L, Ligr M, Daniels G, Peng Y, Wu X, Singh M, Wei J, Shao Y, Lepor H, Xu R, Chang Z, Wang Z, Lee P., Free PMC Article | 01/11/2014 |
| These studies suggest a novel mechanism by which proliferation and differentiation of prostate epithelial cells are controlled by WDR77's location in the cell. | Subcellular localization of p44/WDR77 determines proliferation and differentiation of prostate epithelial cells.
Gao S, Wang Z., Free PMC Article | 05/25/2013 |
| structure of the surprising hetero-octameric complex reveals the close interaction between the seven-bladed beta-propeller MEP50 and the N-terminal domain of PRMT5, and delineates the structural elements of substrate recognition. | Crystal structure of the human PRMT5:MEP50 complex.
Antonysamy S, Bonday Z, Campbell RM, Doyle B, Druzina Z, Gheyi T, Han B, Jungheim LN, Qian Y, Rauch C, Russell M, Sauder JM, Wasserman SR, Weichert K, Willard FS, Zhang A, Emtage S., Free PMC Article | 01/12/2013 |
| p44 plays a role in mediating the effects of hormones during ovarian tumorigenesis. | Expression and function of androgen receptor coactivator p44/Mep50/WDR77 in ovarian cancer.
Ligr M, Patwa RR, Daniels G, Pan L, Wu X, Li Y, Tian L, Wang Z, Xu R, Wu J, Chen F, Liu J, Wei JJ, Lee P., Free PMC Article | 02/18/2012 |
| These results provide a basis for understanding subcellular transport of p44/WDR77 during prostate development and tumorigenesis. | Nuclear transport signals control cellular localization and function of androgen receptor cofactor p44/WDR77.
Gu Z, Zhou L, Gao S, Wang Z., Free PMC Article | 11/26/2011 |
| expression and function of p44 in breast cancer; expression of p44 shows strong cytoplasmic expression in morphologically normal terminal ductal lobular units, while nuclear p44 is observed in both ductal carcinoma in situ and invasive carcinoma | Androgen receptor coactivator p44/Mep50 in breast cancer growth and invasion.
Peng Y, Li Y, Gellert LL, Zou X, Wang J, Singh B, Xu R, Chiriboga L, Daniels G, Pan R, Zhang DY, Garabedian MJ, Schneider RJ, Wang Z, Lee P., Free PMC Article | 03/26/2011 |