Recruitment of the m(6)A/m6Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48.
Nabeel-Shah S, Pu S, Burke GL, Ahmed N, Braunschweig U, Farhangmehr S, Lee H, Wu M, Ni Z, Tang H, Zhong G, Marcon E, Zhang Z, Blencowe BJ, Greenblatt JF., Free PMC Article

FTO blocks RNA translational activity via the loss of N6-methyladenosine methylation at 5' UTR regulated by RBM5 in cisplatin-resistant NSCLC.
Li L, Qu D, Wang B, Yuan S, Zhao Y, Liu N, Huo F, Zhang D, Zhang L.

[Effect of Sedentary behaviors on the Interaction Between the FTO Gene and Adiposity Levels in Chilean Adults - Results from the GENADIO Study].
Celis-Morales C, Villagrán M, Mardones L, Martínez-Sanguinetti MA, Leiva-Ordoñez AM, Carrasco-Marín F, Ulloa N, Martorell M, Lasserre-Laso N, Díaz-Martinez X, Cigarroa I, Concha-Cisternas Y, Troncoso-Pantoja C, Lanuza F, Vásquez-Gómez J, Parra-Soto S, Petermann-Rocha F.

FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis.
Ruan DY, Li T, Wang YN, Meng Q, Li Y, Yu K, Wang M, Lin JF, Luo LZ, Wang DS, Lin JZ, Bai L, Liu ZX, Zhao Q, Wu XY, Ju HQ, Xu RH., Free PMC Article

The composite alliance of FTO locus with obesity-related genetic variants.
Chauhdary Z, Rehman K, Akash MSH.

Fat mass and obesity-associated protein (FTO)-induced upregulation of flotillin-2 (FLOT2) contributes to cancer aggressiveness in diffuse large B-cell lymphoma (DLBCL) via activating the PI3K/Akt/mTOR signal pathway.
Zhang Y, Chen Y, Guo Q, Zhang Y, Liu A.

Common genetic variants associated with obesity in an African-American and Hispanic/Latino population.
Chalazan B, Palm D, Sridhar A, Lee C, Argos M, Daviglus M, Rehman J, Konda S, Darbar D., Free PMC Article

Associations of the obesity gene FTO variant with complications and comorbidities in patients with type 1 diabetes.
Słomiński B, Skrzypkowska M, Myśliwiec M, Trzonkowski P.

Fat mass and obesity-associated protein (FTO) mediated m(6)A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay.
Wu X, Fang Y, Gu Y, Shen H, Xu Y, Xu T, Shi R, Xu D, Zhang J, Leng K, Shu Y, Ma P., Free PMC Article

FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner.
Yin Z, Guo X, Liang X, Wang Z.

FTO Positively Regulates Odontoblastic Differentiation via SMOC2 in Human Stem Cells from the Apical Papilla under Inflammatory Microenvironment.
Huang Q, Sun Y, Huang W, Zhang F, He H, He Y, Huang F., Free PMC Article

FTO promotes the progression of retinoblastoma through YTHDF2-dependent N6-methyladenosine modification in E2F3.
Xie W, Shao Y, Bo Q, Li Z, Yu Q, Wang L, Wu G.

FTO protein regulates the TGF-β signalling pathway through RNA N6-methyladenosine modification to induce unexplained recurrent spontaneous abortion.
Zhang J, Liu X, Gao Y.

circFTO from M2 macrophage-derived small extracellular vesicles (sEV) enhances NSCLC malignancy by regulation miR-148a-3pPDK4 axis.
Liu Q, Xu P, Jin M, Wang L, Hu F, Yang Q, Bi R, Xiao H, Jiang L, Ding F., Free PMC Article

MicroRNA-192-5p downregulates Fat Mass and Obesity-associated Protein to aggravate renal ischemia/reperfusion injury.
Zhang C, Guan G, Wang J, Wei H, Cai J., Free PMC Article

Efficacy of a Comprehensive Weight Reduction Intervention in Male Adolescents With Different FTO Genotypes.
Roumi Z, Salimi Z, Mahmoudi Z, Mobarakeh KA, Ladaninezhad M, Zeinalabedini M, Keshavarz Mohammadian M, Shamsi-Goushki A, Saeedirad Z, Bahar B, Khoshdooz S, Kalantari N, Azizi Tabesh G, Doaei S, Gholamalizadeh M., Free PMC Article

The rs1477196 SNP of the FTO Gene is Associated with Primary Knee Osteoarthritis in a Female Population from Northern Mexico.
Arellano-Pérez-Vertti RD, González-Galarza FF, Prone-Olazábal D, Arellano-Ramírez DO, Arellano-Ramírez DF, Argüello-Beltrán CS, Tovar-Aguilar MA, Berúmen-Rodríguez M, Prieto-Hinojosa AI, Méndez-Hernández A, Argüello-Astorga R.

The m(6)A demethylase FTO targets POLQ to promote ccRCC cell proliferation and genome stability maintenance.
He Y, Chen Y, Li Z, Wu C., Free PMC Article

Exosome-shuttled FTO from BM-MSCs contributes to cancer malignancy and chemoresistance in acute myeloid leukemia by inducing m6A-demethylation: A nano-based investigation.
Kou R, Li T, Fu C, Jiang D, Wang Y, Meng J, Zhong R, Liang C, Dong M.

Evaluation of the role of FTO (rs9939609) and MC4R (rs17782313) gene polymorphisms in type 1 diabetes and their relation to obesity.
Mosaad YM, Morzak M, Abd El Aziz El Chennawi F, Elsharkawy AA, Abdelsalam M.

Fat mass and obesity-associated (FTO) gene is essential for insulin secretion and β-cell function: In vitro studies using INS-1 cells and human pancreatic islets.
Taneera J, Khalique A, Abdrabh S, Mohammed AK, Bouzid A, El-Huneidi W, Bustanji Y, Sulaiman N, Albasha S, Saber-Ayad M, Hamad M.

FTO is a major genetic link between breast cancer, obesity, and diabetes.
Gholami M.

RNA N6-methyladenosine demethylase FTO targets MOXD1 promoting the malignant phenotype of gastric cancer.
Lai Y, Dong H, Xu P, Wang J, Feng W, Zhao Z, Sha L., Free PMC Article

Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis.
Ma Y, Zhang X, Xuan B, Li D, Yin N, Ning L, Zhou YL, Yan Y, Tong T, Zhu X, Huang X, Hu M, Wang Z, Cui Z, Li H, Wang J, Fang JY, Liu R, Chen H, Hong J.

FTO genotypes (rs9939609 T>A) are Associated with Increased Added Sugar Intake in Healthy Young Adults.
Madrigal-Juarez A, Martínez-López E, Sanchez-Murguia T, Magaña-de la Vega L, Rodriguez-Echevarria R, Sepulveda-Villegas M, Torres-Valadez R, Torres-Castillo N.