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    KCTD15 potassium channel tetramerization domain containing 15 [ Homo sapiens (human) ]

    Gene ID: 79047, updated on 10-Oct-2024

    GeneRIFs: Gene References Into Functions

    Submit: New GeneRIFCorrection

    GeneRIFPubMed TitleDate
    BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome.

    BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome.
    Miller KA, Cruz Walma DA, Pinkas DM, Tooze RS, Bufton JC, Richardson W, Manning CE, Hunt AE, Cros J, Hartill V, Parker MJ, McGowan SJ, Twigg SRF, Chalk R, Staunton D, Johnson D, Wilkie AOM, Bullock AN., Free PMC Article

    		05/9/2024
    KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis.

    KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis.
    Raymundo JR, Zhang H, Smaldone G, Zhu W, Daly KE, Glennon BJ, Pecoraro G, Salvatore M, Devine WA, Lo CW, Vitagliano L, Marneros AG., Free PMC Article

    		02/22/2024
    KCTD15 deregulation is associated with alterations of the NF-kappaB signaling in both pathological and physiological model systems.

    KCTD15 deregulation is associated with alterations of the NF-κB signaling in both pathological and physiological model systems.
    Smaldone G, Coppola L, Pane K, Franzese M, Beneduce G, Parasole R, Menna G, Vitagliano L, Salvatore M, Mirabelli P., Free PMC Article

    		12/11/2021
    The KCTD15 rs287103 T variant allele was associated with increased risk of bulimia nervosa and with scores of psychopathological scales of these patients.

    Influence of TFAP2B and KCTD15 genetic variability on personality dimensions in anorexia and bulimia nervosa.
    Gamero-Villarroel C, González LM, Rodríguez-López R, Albuquerque D, Carrillo JA, García-Herráiz A, Flores I, Gervasini G., Free PMC Article

    		07/21/2018
    SEC16B, MC4R, MAP2K5 and KCTD15 (rs17782313, rs543874, rs2241423 and rs11084753) polymorphisms are associated with the risk for children obesity in China.

    Genetic variations in SEC16B, MC4R, MAP2K5 and KCTD15 were associated with childhood obesity and interacted with dietary behaviors in Chinese school-age population.
    Lv D, Zhang DD, Wang H, Zhang Y, Liang L, Fu JF, Xiong F, Liu GL, Gong CX, Luo FH, Chen SK, Li ZL, Zhu YM.

    		05/2/2015
    These data suggest that the non-SUMOylated form of Kctd15 functions in neural crest development.

    The BTB-containing protein Kctd15 is SUMOylated in vivo.
    Zarelli VE, Dawid IB., Free PMC Article

    		08/9/2014
    Data show the synthetic effect of SNPs on the indices of adiposity and risk of obesity in Chinese girls, but failed to replicate the effect of five separate variants of SEC16B rs10913469, SH2B1 rs4788102, PCSK1 rs6235, KCTD15 rs29941 and BAT2 rs2844479.

    Sex-dependent associations of genetic variants identified by GWAS with indices of adiposity and obesity risk in a Chinese children population.
    Xi B, Shen Y, Reilly KH, Zhao X, Cheng H, Hou D, Wang X, Mi J.

    		04/5/2014
    results indicate that Kctd15 acts in the embryo at least in part by specifically binding to the activation domain of AP-2alpha, thereby blocking the function of this critical factor in the neural crest induction hierarchy.

    Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2.
    Zarelli VE, Dawid IB., Free PMC Article

    		04/27/2013
    Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)See all PubMed (2) articles

    MC4R variant is associated with BMI but not response to resistance training in young females.
    Orkunoglu-Suer FE, Harmon BT, Gordish-Dressman H, Clarkson PM, Thompson PD, Angelopoulos TJ, Gordon PM, Hubal MJ, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Hoffman EP, Devaney JM.

    Genes and lifestyle factors in obesity: results from 12,462 subjects from MONICA/KORA.
    Holzapfel C, Grallert H, Huth C, Wahl S, Fischer B, Döring A, Rückert IM, Hinney A, Hebebrand J, Wichmann HE, Hauner H, Illig T, Heid IM.

    		06/30/2010
    Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)See all PubMed (5) articles

    Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.
    Fontaine-Bisson B, Renström F, Rolandsson O, MAGIC, Payne F, Hallmans G, Barroso I, Franks PW.

    Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth.
    Elks CE, Loos RJ, Sharp SJ, Langenberg C, Ring SM, Timpson NJ, Ness AR, Davey Smith G, Dunger DB, Wareham NJ, Ong KK.

    Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.
    Ng MC, Tam CH, So WY, Ho JS, Chan AW, Lee HM, Wang Y, Lam VK, Chan JC, Ma RC.

    Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus.
    He M, Cornelis MC, Franks PW, Zhang C, Hu FB, Qi L.

    Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies.
    Li S, Zhao JH, Luan J, Luben RN, Rodwell SA, Khaw KT, Ong KK, Wareham NJ, Loos RJ.

    		12/2/2009
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (9) articles

    Analyses of shared genetic factors between asthma and obesity in children.
    Melén E, Himes BE, Brehm JM, Boutaoui N, Klanderman BJ, Sylvia JS, Lasky-Su J.

    Obesity and diabetes genetic variants associated with gestational weight gain.
    Stuebe AM, Lyon H, Herring AH, Ghosh J, Wise A, North KE, Siega-Riz AM.

    Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.
    den Hoed M, Ekelund U, Brage S, Grontved A, Zhao JH, Sharp SJ, Ong KK, Wareham NJ, Loos RJ.

    Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
    Morgan AR, Thompson JM, Murphy R, Black PN, Lam WJ, Ferguson LR, Mitchell EA.

    Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study.
    Haupt A, Thamer C, Heni M, Machicao F, Machann J, Schick F, Stefan N, Fritsche A, Häring HU, Staiger H.

    Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.
    Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Kawamoto M, Ueno T, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y.

    Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?
    Brandys MK, van Elburg AA, Loos RJF, Bauer F, Hendriks J, van der Schouw YT, Adan RAH.

    Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference.
    Bauer F, Elbers CC, Adan RA, Loos RJ, Onland-Moret NC, Grobbee DE, van Vliet-Ostaptchouk JV, Wijmenga C, van der Schouw YT.

    Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.
    Renström F, Payne F, Nordström A, Brito EC, Rolandsson O, Hallmans G, Barroso I, Nordström P, Franks PW, GIANT Consortium.

    		02/11/2009
    Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)

    Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
    Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N, Wellcome Trust Case Control Consortium, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN, Genetic Investigation of ANthropometric Traits Consortium., Free PMC Article

    		01/11/2009
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