| Interaction of MRPL9 and GGCT Promotes Cell Proliferation and Migration by Activating the MAPK/ERK Pathway in Papillary Thyroid Cancer. | Interaction of MRPL9 and GGCT Promotes Cell Proliferation and Migration by Activating the MAPK/ERK Pathway in Papillary Thyroid Cancer.
Zhang HM, Li ZY, Dai ZT, Wang J, Li LW, Zong QB, Li JP, Zhang TC, Liao XH., Free PMC Article | 10/22/2022 |
| MiR-205-5p/GGCT Attenuates Growth and Metastasis of Papillary Thyroid Cancer by Regulating CD44. | MiR-205-5p/GGCT Attenuates Growth and Metastasis of Papillary Thyroid Cancer by Regulating CD44.
Li HN, Zhang HM, Li XR, Wang J, Xu T, Li SY, Dong ML, Wang G, Cui XQ, Yang X, Wu YL, Liao XH, Du YY., Free PMC Article | 05/14/2022 |
| miR-877 inhibits the proliferation, migration, and invasion of osteosarcoma cells by targeting gamma-glutamylcyclotransferase. | miR-877 inhibits the proliferation, migration, and invasion of osteosarcoma cells by targeting gamma-glutamylcyclotransferase.
Jia C, Gao J, Wang L, Li Z, Dong Z, Yao L, Yao X. | 01/29/2022 |
| [The expression of GGCT in the bladder urothelial cell carcinoma and its clinical significance]. | [The expression of GGCT in the bladder urothelial cell carcinoma and its clinical significance].
Guo YS, Wu YD, Ma H, Qi L, Zhang SD, Zang YJ. | 11/27/2021 |
| gamma-Glutamyl cyclotransferase contributes to endometrial carcinoma malignant progression and upregulation of PD-L1 expression during activation of epithelial-mesenchymal transition. | γ-Glutamyl cyclotransferase contributes to endometrial carcinoma malignant progression and upregulation of PD-L1 expression during activation of epithelial-mesenchymal transition.
Xu S, Yang Y, Wang X, Liu X, Jin C, Ma M, Wu S, Li Y. | 01/9/2021 |
| a role for EP2/EP4 signaling in regulating IGF-1-induced cell proliferation, in which EP2/EP4 signaling represses IGF-1-induced GGCT expression, is reported. | Inhibition of EP2/EP4 prostanoid receptor-mediated signaling suppresses IGF-1-induced proliferation of pancreatic cancer BxPC-3 cells via upregulating γ-glutamyl cyclotransferase expression.
Takahashi T, Ichikawa H, Morimoto Y, Tsuneyama K, Hijikata T. | 07/4/2020 |
| FOXO3a is identified as a mediator for p21 upregulation by GGCT depletion. AMPK is required for the FOXO3a-mediated p21 upregulation by GGCT depletion. AMPK-FOXO3a-p21 axis plays a role in cancer cell growth inhibition by GGCT depletion. | Depletion of gamma-glutamylcyclotransferase inhibits cancer cell growth by activating the AMPK-FOXO3a-p21 axis.
Taniguchi K, Ii H, Kageyama S, Takagi H, Chano T, Kawauchi A, Nakata S. | 06/13/2020 |
| GGCT is highly upregulated in HGSC tissues and associated with FIGO stage, lymph node metastasis and ascitic fluid volume. High expression of GGCT is associated with poor survival in HGSC patients. | γ-Glutamyl cyclotransferase contributes to tumor progression in high grade serous ovarian cancer by regulating epithelial-mesenchymal transition via activating PI3K/AKT/mTOR pathway.
Li Y, Wu T, Wang Y, Yang L, Hu C, Chen L, Wu S. | 07/14/2018 |
| Taken together, the results indicate that PHB2 plays a central role in p21 upregulation following GGCT knockdown and as such may promote deregulated proliferation of cancer cells by suppressing p21. | Prohibitin-2 is a novel regulator of p21(WAF1/CIP1) induced by depletion of γ-glutamylcyclotransferase.
Taniguchi K, Matsumura K, Kageyama S, Ii H, Ashihara E, Chano T, Kawauchi A, Yoshiki T, Nakata S. | 02/17/2018 |
| GGCT plays a critical role in glioma cell proliferation and may be a potential cancer therapeutic target. | Gamma-glutamylcyclotransferase promotes the growth of human glioma cells by activating Notch-Akt signaling.
Shen SH, Yu N, Liu XY, Tan GW, Wang ZX. | 08/6/2016 |
| GGCT is promising as a diagnostic marker and a therapeutic target for various cancers. This review summarizes these interesting findings. | Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and Treatment.
Kageyama S, Hanada E, Ii H, Tomita K, Yoshiki T, Kawauchi A., Free PMC Article | 05/21/2016 |
| G6PD, GGCT, IDH1, isocitrate dehydrogenase 2 (NADP+,mitochondrial) (IDH2) and glutathione S-transferase pi 1(GSTP1), five of the critical components of GSH pathway, contribute to chemoresistance. | Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis.
Wang Z, Liang S, Lian X, Liu L, Zhao S, Xuan Q, Guo L, Liu H, Yang Y, Dong T, Liu Y, Liu Z, Zhang Q., Free PMC Article | 03/26/2016 |
| GGCT plays a critical role in lung cancer cell proliferation. | γ-Glutamylcyclotransferase Knockdown Inhibits Growth of Lung Cancer Cells Through G0/G1 Phase Arrest.
Lin Z, Xiong L, Zhou J, Wang J, Li Z, Hu H, Lin Q. | 03/19/2016 |
| Transcriptional silencing of the C7orf24 gene in the non-malignant cells is elicited through heterochromatin formation in its promoter region. | Association of epigenetic alterations in the human C7orf24 gene with the aberrant gene expression in malignant cells.
Ohno Y, Hattori A, Yoshiki T, Kakeya H. | 03/29/2014 |
| increased expression of GGCT was a common event among invasive esophageal squamous cell carcinoma tissues regardless of the depth of invasion. Lymph node metastasis and tumor differentiation correlated with GGCT expression | γ-Glutamylcyclotransferase as a novel immunohistochemical biomarker for the malignancy of esophageal squamous tumors.
Takemura K, Kawachi H, Eishi Y, Kitagaki K, Negi M, Kobayashi M, Uchida K, Inoue J, Inazawa J, Kawano T, Board PG. | 03/15/2014 |
| C7orf24 has been recognized as a potent marker for bladder and breast cancers. Studies on the role of gamma-glutamylcyclotransferace may aid in the control of malignant transformation of these cancers. | [C7orf24/gamma-glutamyl cyclotransferase as a molecular target for cancer chemotherapy].
Ohno Y, Hattori A, Kakeya H. | 09/21/2013 |
| GGCT may be a biomarker of tumors in a limited range of organs. | Widespread expression of γ-glutamyl cyclotransferase suggests it is not a general tumor marker.
Amano T, Eishi Y, Yamada T, Uchida K, Minegishi K, Tamura T, Kobayashi D, Hiroshi K, Suzuki T, Board PG., Free PMC Article | 02/11/2012 |
| C7orf24 overexpression defines a subgroup of breast tumors with poor clinical outcome. | Proteomic profiling of mammary carcinomas identifies C7orf24, a gamma-glutamyl cyclotransferase, as a potential cancer biomarker.
Gromov P, Gromova I, Friis E, Timmermans-Wielenga V, Rank F, Simon R, Sauter G, Moreira JM. | 12/11/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Polymorphisms in innate immunity genes and risk of childhood leukemia.
Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesRisk of meningioma and common variation in genes related to innate immunity.
Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD. Common variation in genes related to innate immunity and risk of adult glioma.
Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ. | 06/30/2010 |
| The GGCT gene is located on chromosome 7p14-15 and consists of four exons that span 8 kb, the primary sequence is 188 amino acids in length and is unlike any protein of known function | The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle.
Oakley AJ, Yamada T, Liu D, Coggan M, Clark AG, Board PG. | 01/21/2010 |
| presence of extra electron density/ligands and conservation at the sequence and structure levels, it is likely that the cavity has a crucial role in the function of LOC79017 and its structural neighbors possibly as an active site or ligand-binding site | Crystal structure of Homo sapiens protein LOC79017.
Bae E, Bingman CA, Aceti DJ, Phillips GN Jr. | 01/21/2010 |
| CRF21 might play an important role in the induction of apoptosis by GGO in leukemia U937 cells. | A novel 21-kDa cytochrome c-releasing factor is generated upon treatment of human leukemia U937 cells with geranylgeraniol.
Masuda Y, Maeda S, Watanabe A, Sano Y, Aiuchi T, Nakajo S, Itabe H, Nakaya K. | 01/21/2010 |