| ZNF224 is a mediator of TGF-beta pro-oncogenic function in melanoma. | ZNF224 is a mediator of TGF-β pro-oncogenic function in melanoma.
Cesaro E, Pastore A, Polverino A, Manna L, Divisato G, Quintavalle C, Sanzo MD, Faniello MC, Grosso M, Costanzo P. | 04/2/2022 |
| ZNF224 Protein: Multifaceted Functions Based on Its Molecular Partners. | ZNF224 Protein: Multifaceted Functions Based on Its Molecular Partners.
Cesaro E, Lupo A, Rapuano R, Pastore A, Grosso M, Costanzo P., Free PMC Article | 12/25/2021 |
| identify the receptor tyrosine kinase Axl as a novel target of ZNF224 transcriptional repression activity. | ZNF224 is a transcriptional repressor of AXL in chronic myeloid leukemia cells.
Sodaro G, Blasio G, Fiorentino F, Auberger P, Costanzo P, Cesaro E. | 12/1/2018 |
| The analyses using human breast ductal carcinoma tissues exhibited that the expression of ZNF224 and miR-663a was increased in cancer compared to non-cancer region. | ZNF224, Krüppel like zinc finger protein, induces cell growth and apoptosis-resistance by down-regulation of p21 and p53 via miR-663a.
Cho JG, Park S, Lim CH, Kim HS, Song SY, Roh TY, Sung JH, Suh W, Ham SJ, Lim KH, Park SG., Free PMC Article | 01/20/2018 |
| we showed that ZNF224 positively modulates cyclin D3 gene expression. Consistently, we observed that alteration of ZNF224 expression leads to defects in cell cycle control. All together, our results strongly suggest that in Chronic lymphocytic leukaemia (CLL)cells high expression level of ZNF224 can lead to inappropriate cell growth and apoptosis resistance, thus contributing to CLL progression | Role of ZNF224 in cell growth and chemoresistance of chronic lymphocitic leukemia.
Busiello T, Ciano M, Romano S, Sodaro G, Garofalo O, Bruzzese D, Simeone L, Chiurazzi F, Fiammetta Romano M, Costanzo P, Cesaro E. | 09/23/2017 |
| Increasing information on the mechanism through which ZNF224 can operate could lead to the identification of agents capable of modulating ZNF224 function, thus potentially paving the way to new therapeutic strategies for treatment of cancer | The Complex Role of the ZNF224 Transcription Factor in Cancer.
Cesaro E, Sodaro G, Montano G, Grosso M, Lupo A, Costanzo P. | 06/24/2017 |
| Data show that Wilms' tumor 1 protein (WT1)binds to the zinc finger protein 224 (ZNF224) promoter and represses ZNF224 expression. | WT1-mediated repression of the proapoptotic transcription factor ZNF224 is triggered by the BCR-ABL oncogene.
Montano G, Vidovic K, Palladino C, Cesaro E, Sodaro G, Quintarelli C, De Angelis B, Errichiello S, Pane F, Izzo P, Grosso M, Gullberg U, Costanzo P., Free PMC Article | 08/6/2016 |
| ZNF224 acts in fine tuning of WT1-dependent control of gene expression, acting as a co-activator of WT1 in the regulation of proapoptotic genes and suppressing WT1 mediated transactivation of antiapoptotitc genes. | Role of WT1-ZNF224 interaction in the expression of apoptosis-regulating genes.
Montano G, Cesaro E, Fattore L, Vidovic K, Palladino C, Crescitelli R, Izzo P, Turco MC, Costanzo P. | 11/16/2013 |
| REVIEW: ZNF224 is a multifunctional protein and alternative splicing, sub-cellular compartmentalization and isoform-specific interactions may modulate its activity | ZNF224: Structure and role of a multifunctional KRAB-ZFP protein.
Lupo A, Cesaro E, Montano G, Izzo P, Costanzo P. | 06/4/2011 |
| ZNF224 acts as a transcriptional co-regulator of WT1. | Biochemical and functional interaction between ZNF224 and ZNF255, two members of the Kruppel-like zinc-finger protein family and WT1 protein isoforms.
Florio F, Cesaro E, Montano G, Izzo P, Miles C, Costanzo P. | 01/1/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
Shulman JM, Chibnik LB, Aubin C, Schneider JA, Bennett DA, De Jager PL., Free PMC Article | 09/15/2010 |
| Coimmunoprecipitation and immunocytochemistry revealed that DEPDC1 interacted and colocalized with zinc finger transcription factor ZNF224, a known transcriptional repressor. | Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells.
Harada Y, Kanehira M, Fujisawa Y, Takata R, Shuin T, Miki T, Fujioka T, Nakamura Y, Katagiri T. | 08/30/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| ZNF224 recruits the arginine methyltransferase PRMT5 on the transcriptional repressor complex of the aldolase A gene | The Kruppel-like zinc finger protein ZNF224 recruits the arginine methyltransferase PRMT5 on the transcriptional repressor complex of the aldolase A gene.
Cesaro E, De Cegli R, Medugno L, Florio F, Grosso M, Lupo A, Izzo P, Costanzo P., Free PMC Article | 01/21/2010 |
| CIC silencer activity extends over 26 bp (-595/-569), which specifically bind a protein ZNF224 present in HepG2 cell nuclear extracts. | Transcription of the mitochondrial citrate carrier gene: identification of a silencer and its binding protein ZNF224.
Iacobazzi V, Infantino V, Convertini P, Vozza A, Agrimi G, Palmieri F. | 01/21/2010 |
| Differential expression and cellular localization of ZNF224 and ZNF255, two isoforms of the Kruppel-like zinc-finger protein family. | Differential expression and cellular localization of ZNF224 and ZNF255, two isoforms of the Krüppel-like zinc-finger protein family.
Medugno L, Florio F, Cesaro E, Grosso M, Lupo A, Izzo P, Costanzo P. | 01/21/2010 |
| We demonstrate that ZNF224, a Kruppel-like zinc finger transcription factor, is the repressor protein that specifically binds to the negative cis-element AldA-NRE and affects the AldA-NRE-mediated transcription | A novel zinc finger transcriptional repressor, ZNF224, interacts with the negative regulatory element (AldA-NRE) and inhibits gene expression.
Medugno L, Costanzo P, Lupo A, Monti M, Florio F, Pucci P, Izzo P. | 01/21/2010 |
| Results suggest that bone marrow zinc finger 2 (BMZF2) interferes with the transactivation potential of Wilms tumor suppressor gene (WT1). | Inhibition of Wilms tumor 1 transactivation by bone marrow zinc finger 2, a novel transcriptional repressor.
Lee TH, Lwu S, Kim J, Pelletier J. | 01/21/2010 |