| Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation. | Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation.
Buglak DB, Bougaran P, Kulikauskas MR, Liu Z, Monaghan-Benson E, Gold AL, Marvin AP, Burciu A, Tanke NT, Oatley M, Ricketts SN, Kinghorn K, Johnson BN, Shiau CE, Rogers S, Guilluy C, Bautch VL., Free PMC Article | 04/4/2023 |
| The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal. | The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
Hieda M, Matsumoto T, Isobe M, Kurono S, Yuka K, Kametaka S, Wang JY, Chi YH, Kameda K, Kimura H, Matsuura N, Matsuura S., Free PMC Article | 12/18/2021 |
| Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy. | Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy.
Chai RJ, Werner H, Li PY, Lee YL, Nyein KT, Solovei I, Luu TDA, Sharma B, Navasankari R, Maric M, Sim LYE, Loh YJ, Aliwarga E, Cheong JWL, Chojnowski A, Autio MI, Haiyang Y, Boon Tan KK, Keng CT, Ng SL, Chew WL, Ferenczi M, Burke B, Foo RSY, Stewart CL., Free PMC Article | 08/14/2021 |
| The SUN1-SPDYA interaction plays an essential role in meiosis prophase I. | The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
Chen Y, Wang Y, Chen J, Zuo W, Fan Y, Huang S, Liu Y, Chen G, Li Q, Li J, Wu J, Bian Q, Huang C, Lei M., Free PMC Article | 06/12/2021 |
| SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells. | SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
Porter L, Minaisah RM, Ahmed S, Ali S, Norton R, Zhang Q, Ferraro E, Molenaar C, Holt M, Cox S, Fountain S, Shanahan C, Warren D., Free PMC Article | 01/16/2021 |
| Comparison of the miRNA profiles between wildtype and SUN1 null myotubes identified a cluster of miRNAs encoded by a non-translated retrotransposon-like one antisense (Rtl1as) transcript that are decreased in the WT myoblasts due to SUN1 inhibition of Drosha | The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity.
Loo TH, Ye X, Chai RJ, Ito M, Bonne G, Ferguson-Smith AC, Stewart CL., Free PMC Article | 05/9/2020 |
| Results provide evidence that SUN1 and KASH5 are essential factors in the regulation of meiotic resumption and spindle formation. | Depletion of the LINC complex disrupts cytoskeleton dynamics and meiotic resumption in mouse oocytes.
Luo Y, Lee IW, Jo YJ, Namgoong S, Kim NH., Free PMC Article | 01/14/2017 |
| A cell-type-specific role for Sun1 and Sun2 in nucleokinesis during cerebellar development, is reported. | Sun1 deficiency leads to cerebellar ataxia in mice.
Wang JY, Yu IS, Huang CC, Chen CY, Wang WP, Lin SW, Jeang KT, Chi YH., Free PMC Article | 04/23/2016 |
| ablation of the kinase CDK2 alters the nuclear envelope in mouse spermatocytes, and that the proteins SUN1, KASH5 (also known as CCDC155) and lamin C2 show an abnormal cap-like distribution facing the centrosome. | CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase.
Viera A, Alsheimer M, Gómez R, Berenguer I, Ortega S, Symonds CE, Santamaría D, Benavente R, Suja JA. | 07/25/2015 |
| our results clearly indicate that SUN1 and SUN2, at least partially, fulfill redundant meiotic functions | Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function.
Link J, Leubner M, Schmitt J, Göb E, Benavente R, Jeang KT, Xu R, Alsheimer M., Free PMC Article | 12/20/2014 |
| Sun1, a component of LINC complexes, but not A-type lamins, which interact with LINC complexes at the nuclear envelope, participate in cone nuclei positioning. | LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina.
Razafsky D, Blecher N, Markov A, Stewart-Hutchinson PJ, Hodzic D., Free PMC Article | 04/6/2013 |
| Sun1 has a role in DNA damage response. | Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response.
Lei K, Zhu X, Xu R, Shao C, Xu T, Zhuang Y, Han M., Free PMC Article | 02/23/2013 |
| It was shown KASH5 possesses hitherto unknown KASH-related sequences that directly interacted with SUN1 and mediated telomere localization. KASH5 interacted with the microtubule-associated dynein- dynactin complex. | A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.
Morimoto A, Shibuya H, Zhu X, Kim J, Ishiguro K, Han M, Watanabe Y., Free PMC Article | 10/20/2012 |
| These findings implicate Sun1 protein accumulation as a common pathogenic event in Lmna(-/-), LmnaDelta9 mice, models for Emery-Dreifuss muscular dystrophy and Hutchinson-Gilford progeria disorders. | Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies.
Chen CY, Chi YH, Mutalif RA, Starost MF, Myers TG, Anderson SA, Stewart CL, Jeang KT., Free PMC Article | 06/23/2012 |
| Syne-2, SUN1 and SUN2 play critical roles during interkinetic nuclear migration and photoreceptor cell migration in the mouse retina development. | KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.
Yu J, Lei K, Zhou M, Craft CM, Xu G, Xu T, Zhuang Y, Xu R, Han M., Free PMC Article | 06/25/2011 |
| Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development | Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.
Randles KN, Lam le T, Sewry CA, Puckelwartz M, Furling D, Wehnert M, McNally EM, Morris GE., Free PMC Article | 12/11/2010 |
| perturbations in lamin A-SUN1 and SUN2 protein interactions may underlie the opposing effects of EDMD and HGPS mutations on nuclear and cellular mechanics | Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes.
Haque F, Mazzeo D, Patel JT, Smallwood DT, Ellis JA, Shanahan CM, Shackleton S., Free PMC Article | 03/1/2010 |
| The study indicated that the SUN1-KASH complexes mediate the coupling between the nucleus and the centrosome and provide anchors in the nuclear envelope for cytoplasmic dynein/dynactin during neuronal migration. | SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.
Zhang X, Lei K, Yuan X, Wu X, Zhuang Y, Xu T, Xu R, Han M., Free PMC Article | 01/21/2010 |
| These results clearly indicate that SUN1 and SUN2 function critically in skeletal muscle cells for Syne-1 localization at the nuclear envelope, which is essential for proper myonuclear positioning. | SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice.
Lei K, Zhang X, Ding X, Guo X, Chen M, Zhu B, Xu T, Zhuang Y, Xu R, Han M., Free PMC Article | 01/21/2010 |
| Sun1-/- P14 testes are repressed for the expression of reproductive genes and have no detectable piRNA | Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA.
Chi YH, Cheng LI, Myers T, Ward JM, Williams E, Su Q, Faucette L, Wang JY, Jeang KT., Free PMC Article | 01/21/2010 |
| The Sun1 serves as a 'structural bridge' connecting the nuclear interior with the actin cytoskeleton. | The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.
Padmakumar VC, Libotte T, Lu W, Zaim H, Abraham S, Noegel AA, Gotzmann J, Foisner R, Karakesisoglou I. | 01/21/2010 |
| SUN1 and SUN2 may form a physical interaction between the nuclear envelope and the centrosome | Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome.
Wang Q, Du X, Cai Z, Greene MI. | 01/21/2010 |
| SUN1 interacts with nuclear lamin A and cytoplasmic nesprins (nesprin-1 and nesprin-2)to provide a physical connection between the nuclar lamina and the cytoskeleton. | SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.
Haque F, Lloyd DJ, Smallwood DT, Dent CL, Shanahan CM, Fry AM, Trembath RC, Shackleton S., Free PMC Article | 01/21/2010 |